Primary carboxamides as btk inhibitors

Abstract

The invention provides compounds of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.

1 . A compound of Formula (I): 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt, pro-drug, biologically active metabolite, isomer, or stereoisomer thereof, wherein:
 X is NR 2  or S; 
 Y is N or CR 1 , and Z is N or CR 1 ; or, Y is CR 1 R 2  and Z is CR 1 R 2 ; 
 A is N or CR 4 ; 
 E is N or CR 5 ; 
 R 1  is independently H, deuterium, CN, halogen, CF 3 , —NR c R c , —N(R a )C(O)R b , optionally substituted (C 1 -C 6 )alkyl, optionally substituted (C 2 -C 6 )alkenyl, optionally substituted aryl, optionally substituted (C 3 -C 6 )cycloalkyl, optionally substituted (C 3 -C 6 )cycloalkenyl, optionally substituted heteroaryl, or optionally substituted saturated or partially saturated heterocyclyl; 
 R 2  is independently H, deuterium, or optionally substituted (C 1 -C 3 )alkyl; 
 R 3  is halogen, —N(R a ) 2 , optionally substituted aryl, optionally substituted (C 3 -C 7 )cycloalkyl, optionally substituted saturated or partially saturated heterocyclyl, or optionally substituted heteroaryl; or 
 R 3  is —R 301 -L-R 302  wherein
 R 301  is a bond, —O—, —OCH 2 —, —NR d —, or optionally substituted (C 1 -C 3 )alkylene, and 
 L is optionally substituted phenyl, optionally substituted (C 3 -C 6 )cycloalkyl, optionally substituted heteroaryl or a saturated or partially saturated heterocyclyl containing one or more heteroatoms, at least one of which is nitrogen; or 
 L is -L 1 -L 2  wherein L 1  is attached to R 301  and 
 L 1  is optionally substituted phenyl, optionally substituted heteroaryl or optionally substituted saturated or partially saturated carbocycle or a saturated or partially saturated heterocyclyl; and 
 L 2  is a bond, CH 2 , NR d , CH 2 N(H), S(O) 2 N(H), or —O—; 
 
 R 302  is CN, —CH 2 CN, optionally substituted —C(═O)R 302a , —(CH 2 ) n — optionally substituted saturated or partly saturated heterocyclyl or optionally substituted —S(O) 2 (C 2 )alkenyl;
 wherein R 302a  is optionally substituted (C 1 -C 4 )alkyl, optionally substituted (C 2 -C 4 )alkenyl, (C 2 -C 4 )alkynyl, —C(O)—(C 1 -C 4 )alkyl, optionally substituted saturated or partially unsaturated (C 3 -C 6 )cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, —N(H)— optionally substituted heteroaryl or —(CH 2 ) n — optionally substituted unsaturated or partly saturated heterocyclyl; 
 
 R 4  is H, deuterium, CN, optionally substituted (C 1 -C 3 )alkyl, optionally substituted (C 3 -C 6 ) cycloalkyl or optionally substituted saturated or partially saturated heterocyclyl, or optionally substituted heteroaryl;
 wherein the optionally substituted saturated or partially saturated heterocyclyl; and 
 
 optionally substituted heteroaryl contain at least one nitrogen atom; or 
 R 3  and R 4 , together with the carbon atoms to which they are attached, form an optionally substituted, saturated, unsaturated or partially unsaturated 5 or 6 membered carbocyclic ring or an optionally substituted, saturated, or partially unsaturated 5 or 6 membered heterocyclic ring containing one or more heteroatoms selected from N, S and O; 
 R 5  is H, deuterium, halogen, or optionally substituted (C 1 -C 3 )alkyl; 
 R a  is independently selected from H, —C(O)— optionally substituted (C 2 -C 6 )alkenyl, optionally substituted (C 1 -C 6 )alkyl, —(CH 2 ) n — optionally substituted (C 3 -C 6 )cycloalkyl, —(CH 2 ) n — optionally substituted heterocyclyl, or —(CH 2 ) n — optionally substituted heteroaryl; 
 R b  is H, optionally substituted (C 1 -C 6 )alkyl, optionally substituted (C 2 -C 6 )alkenyl, optionally substituted (C 2 -C 6 )alkynyl, —CH 2 —O— optionally substituted aryl, or —CH 2 —O— optionally substituted heteroaryl; 
 R c  is independently H, optionally substituted (C 1 -C 6 )alkyl, optionally substituted (C 3 -C 6 )cycloalkyl, optionally substituted saturated or partially saturated heterocyclyl, optionally substituted aryl or optionally substituted heteroaryl; 
 R d  is H, optionally substituted heterocyclyl, —(CH 2 )— optionally substituted (C 3 -C 6 )cycloalkyl, —(CH 2 )— optionally substituted heteroaryl or optionally substituted (C 1 -C 3 )alkyl; 
 R f  is optionally substituted (C 1 -C 3 )alkyl, optionally substituted (C 2 -C 4 )alkenyl or optionally substituted (C 2 -C 4 )alkynyl; and 
 n is independently 0 or 1. 
 
     
     
         2 . The compound according to  claim 1 , wherein Y is CR 1  and R 1  of Y is H, optionally substituted ethenyl, optionally substituted ethyl, optionally substituted methyl, optionally substituted 2,3-dihydrobenzofuranyl, optionally substituted 1,4-dioxanyl, optionally substituted 3,4-dihydro-2H-benzo[b][1,4]oxazinyl, optionally substituted 6,7-dihydro-4H-pyrazolo[5,1-c][1,4]oxazinyl, optionally substituted chromanyl, optionally substituted cyclohexenyl, optionally substituted cyclopropyl, optionally substituted tetrahydrofuranyl, optionally substituted isochromanyl, optionally substituted 1,2,3,4-tetrahydro-isoquinolinyl, optionally substituted isoxazolyl, optionally substituted morpholinyl, optionally substituted oxetanyl, optionally substituted phenyl, optionally substituted piperidinyl, optionally substituted piperazinyl, optionally substituted 3,6-dihydro-2H-pyranyl, optionally substituted pyrano[4,3-b]pyridinyl, optionally substituted pyrazolyl, optionally substituted pyridinyl, optionally substituted 3H-pyridin-1-one, optionally substituted 1,2,3,6-tetrahydropyridinyl, optionally substituted pyrimidinyl, optionally substituted pyrrolidinyl, optionally substituted 2,5-dihydropyrrolyl, optionally substituted tetrahydropyranyl or optionally substituted tetrahydro-2H-thiopyranyl. 
     
     
         3 . The compound according to  claim 2  wherein R 1  is H or R 1  is optionally substituted by one or more substituents independently selected from the group consisting of CN, OH, ═O, halogen, (C 1 -C 4 )alkyl, (C 1 -C 4 )alkoxy, —CH 2 CH 2 OH, —CH 2 C(CH 3 ) 2 OH, —CH 2 CH(OH)CH 2 OH, —CH═CH 2 , —CH 2 NH 2 , —CH 2 N(H)C(O)R e , —C(O)(C 1 -C 4 )alkyl, —C(O)(C 1 -C 4 )alkoxy, —C(O)NH 2 , —C(O)N(CH 3 ) 2 , —C(O)— optionally substituted heterocyclyl, —N(H)C(O)CH 3 , N(CH 3 ) 2 , —S(O) 2 (C 1 -C 4 )alkyl, —S(O) 2 -pyrrolidinyl, (C 1 -C 4 )alkoxy, —CH 2 -morpholinyl, —CH 2 CH 2 -morpholinyl, morpholinyl, tetrahydropyranyl;
 wherein R e  is (C 1 -C 3 )alkyl, —CH 2 Cl, —C≡CH, —C≡CCH 3 , —CH═CH 2 , —CH═CHCH 3 , —C(═CH 2 )CH 3 , —CH 2 CN, —CH 2 CH 2 N(CH 3 ) 2 , —CH 2 CH 2 -piperidinyl, —CH 2 O— optionally substituted phenyl. 
 
     
     
         4 . The compound according to  claim 3 , wherein R 3  is —N(H)C(O)CH═CH 2 , optionally substituted isoxazolyl, optionally substituted phenyl, optionally substituted pyrazolyl, optionally substituted pyridinyl, optionally substituted pyrimidinyl, optionally substituted thiazolyl, or optionally substituted thienyl. 
     
     
         5 . The compound according to  claim 4 , wherein R 3  is optionally substituted by one or more substituents independently selected from —NH 2 , —NHCH 3 , (C 1 -C 4 )alkyl and —C(O)(C 2 -C 4 )alkenyl. 
     
     
         6 . The compound according to  claim 5 , wherein X is NR 2  and R 2  is H. 
     
     
         7 . The compound according to  claim 6 , wherein Y is CR 1  and R 1  of Y is H, optionally substituted phenyl, optionally substituted piperazinyl, optionally substituted pyrazolyl, or optionally substituted 1,2,3,6-tetrahydropyridinyl. 
     
     
         8 . The compound according to  claim 7 , wherein Y is CR 1  and R 1  of Y is optionally substituted by one or more substituents independently selected from halogen, (C 1 -C 4 )alkyl, —C(O)(C 1 -C 4 )alkyl, and —S(O) 2 (C 1 -C 4 )alkyl. 
     
     
         9 . The compound according to  claim 8 , wherein
 Z is N or Z is CR 1  and R 1  of Z is H; and   A is CR 4  and R 4  is H or azetidinyl substituted with —C(O)CH═CH 2 .   
     
     
         10 . The compound according to  claim 9 , wherein the compound is
 4-(3-amino-2-methylphenyl)-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-7-carboxamide;   2-(4-fluorophenyl)-4-(pyridin-3-yl)-1H-indole-7-carboxamide;   4-(pyridin-3-yl)-2-p-tolyl-1H-indole-7-carboxamide;   2-(4-fluorophenyl)-4-(pyridin-4-yl)-1H-indole-7-carboxamide;   2-(4-fluorophenyl)-4-(1H-pyrazol-5-yl)-1H-indole-7-carboxamide;   4-(3,5-dimethylisoxazol-4-yl)-2-p-tolyl-1H-indole-7-carboxamide;   2-(1-acetylpiperidin-4-yl)-4-(3-amino-2-methylphenyl)-1H-indole-7-carboxamide;   4-(pyridin-4-yl)-2-p-tolyl-1H-indole-7-carboxamide;   4-(thiophen-2-yl)-2-p-tolyl-1H-indole-7-carboxamide;   4-(2-aminophenyl)-1H-indole-7-carboxamide;   4-(3-amino-2-methylphenyl)-1H-indole-7-carboxamide;   4-(5-aminopyridin-3-yl)-1H-indole-7-carboxamide;   4-(2-aminopyridin-4-yl)-1H-indole-7-carboxamide;   4-(2-aminoethylamino)-2-(4-fluorophenyl)-1H-indole-7-carboxamide;   4-(2-aminoethylamino)-2-p-tolyl-1H-indole-7-carboxamide;   4-(pyrimidin-5-yl)-2-p-tolyl-1H-indole-7-carboxamide;   4-(1H-pyrazol-4-yl)-2-p-tolyl-1H-indole-7-carboxamide;   4-(1H-pyrazol-5-yl)-2-p-tolyl-1H-indole-7-carboxamide;   2-(4-fluorophenyl)-4-(pyrimidin-5-yl)-1H-indole-7-carboxamide;   4-(thiazol-2-yl)-2-p-tolyl-1H-indole-7-carboxamide;   4-(pyridin-2-yl)-2-p-tolyl-1H-indole-7-carboxamid;   4-(thiophen-3-yl)-2-p-tolyl-1H-indole-7-carboxamide;   4-(1-methyl-1H-pyrazol-4-yl)-2-p-tolyl-1H-indole-7-carboxamide;   4-(1H-pyrazol-3-yl)-2-p-tolyl-1H-indole-7-carboxamide;   4-(2-aminophenyl)-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-7-carboxamide;   2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-4-phenyl-1H-indole-7-carboxamide;   4-(3-amino-2-methylphenyl)-2-(4,4-difluorocyclohex-1-enyl) 1H-indole-7-carboxamide;   4-(3-amino-2-methylphenyl)-1H-pyrrolo[2,3-c]pyridine-7-carboxamide;   4-(1-acryloylpiperidin-3-yl)-1H-indole-7-carboxamide;   4-(1-acryloylpiperidin 3-yl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-indole-7-carboxamide;   4-(2-aminoethylamino)-2-p-tolyl-1H-indole-7-carboxamide;   4-((1R,2R)-2-aminocyclohexylamino)-2-(4-fluorophenyl)-1H-indole-7-carboxamide*;   4-(1-methyl-1H-pyrazol-5-ylamino)-2-p-tolyl-1H-indole-7-carboxamide;   4-iodo-2-(pyridin-3-yl)-1H-indole-7-carboxamide;   4-(3-amino-2-methylphenyl)-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-7-carboxamide;   4-(3,5-dimethylisoxazol-4-yl)-2-(4-fluorophenyl)-1H-indole-7-carboxamide;   4-(2-aminophenyl)-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-7-carboxamide; or   2-(1-Acetylpiperidin-4-yl)-4-(3-amino-2-methylphenyl)-1H-indole-7-carboxamide.   
     
     
         11 . The compound according to  claim 3 , wherein R 3  is —R 301 -L-R 302 , and R 301  is a bond, N(H), N(CH 3 ), CH 2 , C(H)(optionally substituted (C 1 -C 3 )alkyl), O, or OCH 2 . 
     
     
         12 . The compound according to  claim 11  wherein
 L is optionally substituted azetidinyl, optionally substituted cyclopentyl, optionally substituted 3,6-diazabicyclo[3.2.0]heptanyl, optionally substituted 1,4-dioxanyl, optionally substituted morpholinyl, optionally substituted [1,4]oxepanyl, optionally substituted phenyl, optionally substituted piperidinyl, or optionally substituted pyrrolidinyl; or 
 L is L 1 -L 2  wherein 
 L 1  is optionally substituted cyclohexyl, optionally substituted cyclopentyl optionally substituted phenyl, optionally substituted piperidinyl, optionally substituted pyridinyl; 
 L 2  is N(H), N(CH 3 ), N(CH 2 CH 2 OH), N(CH 2 CH(CH 3 ) 2 ), N(oxetanyl), N(CH 2 -cyclopentyl), N(CH 2 -thiazolyl), O, S(O) 2 N(H), or CH 2 N(H). 
 
     
     
         13 . The compound according to  claim 12 , wherein L or L 1  is optionally substituted with one or more substituents independently selected from halogen, CN, OH, (C 1 -C 4 )alkoxy, (C 1 -C 4 )alkyl, —CH 2 OH, —N(H)CH 2 -heteroaryl, benzyloxy, and —OCH 2 -heteroaryl. 
     
     
         14 . The compound according to  claim 13 , wherein R 302  is —C(O)CH 3 , —C(O)C(O)CH 3 , —C(O)CF 2 (Cl), —CH(CH 3 ) 2 , —CH 2 Cl, —CH 2 CN, —C(O)CH 2 CN, —C(O)CH 2 CH 3 , —C(O)CH 2 F, —C(O)CH(CH 3 ) 2 , —C(O)—CH 2 CH(CH 3 ) 2 , —C(O)CH(CH 3 )(Cl), —C(O)CH 2 CH(CH 3 )CH 3 , —C(O)CH(Cl)CH 2 CH 3 , —CH 2 CH 2 OH, —C(O)CH 2 CH 2 N(CH 3 ) 2 , —C(O)CH═CH 2 , —C(O)C≡CH, —C(O)CH═CHCl, —C(O)CH═CHCH 3 , —C(O)C(═CH 2 )CH 3 , —C(O)C(CH 2 CH 3 )═CH 2 , —C(O)CH═CHCH(CH 3 ) 2 , —C(O)CH═CHC(O)OH, —C(O)CH═CHC(O)N(H)CH 2 CH 3 , —C(O)CH═CHCH 2 N(CH 3 ) 2 , —C(O)CH═CHC(O)OCH 3 , —C(O)CH═CHC(O)OCH 2 CH 3 , —C(O)CH═CHC(O)N(H)CH 3 , —C(O)CH═CHC(O)CH 2 CH 2 OCH 3 , —C(O)CH═CHC(O)N(CH 3 ) 2 , —C(O)CH═CHC(O)N(H)CH 2 CH 3 , —C(O)CH═CHC(O)N(H)CH 2 CH 2 OCH 3 , —C(O)CH═CHCH 2 N(H)CH 2 CH 2 OCH 3 , —C(O)C(CN)═C(OH)(CH 3 ), —C(O)CH═CH— optionally substituted pyrazolyl-C(O)CH═CHCH 2 N(H)— optionally substituted cyclopropyl, —C(O)CH═CHCH 2 N(H)CH 2 — optionally substituted tetrahydrofuranyl, —C(O)CH═CHC(O)NH 2 , —C(O)CH═CHC(O)N(H)— optionally substituted cyclopropyl, —C(O)C(CH 3 )═CHCH 3 , —C(O)C(CH 3 )═CHCH 2 CH 3 , —C(O)C(═CH 2 )CH 2 N(CH 3 ) 2 , —C(O)C(═CH 2 )CH 2 NH 2 , —C(O)C(═CH 2 )CH 2 N(H)(CH 3 ), —C(O)C(═CH 2 )CH 3 , —C(O)C(═CH 2 )CH 2 — optionally substituted morpholinyl, —C(O)C(═CH 2 )— optionally substituted phenyl, —CH 2 — optionally substituted benzo[d]isothiazolyl, —C(O)—CH 2 —O— optionally substituted phenyl, —CH 2 — optionally substituted thiazolyl, —CH 2 CH 2 — optionally substituted morpholinyl, —C(O)CH 2 O— optionally substituted phenyl, —C(O)CH 2 CH 2 — optionally substituted piperazinyl, —C(O)CH 2 CH 2 — optionally substituted piperidinyl, —C(O)CH 2 O— optionally substituted pyridinyl, —C(O)CH 2 CH 2  optionally substituted pyrrolidinyl, —C(O)CH═CH optionally substituted cyclopropyl, —C(O)CH═CHCH 2 — optionally substituted morpholinyl, —C(O)CH═CHCH 2 — optionally substituted pi peridinyl, —C(O)CH═CH— optionally substituted pyrazolyl, —C(O)CH═CH— optionally substituted pyridinyl, —C(O)CH═CH— optionally substituted thiazolyl, —C(O)— optionally substituted cyclohexenyl, —C(═O)— optionally substituted cyclohexyl, —C(O)— optionally substituted cyclopentenyl, —C(O)-cyclopentyl, optionally substituted imidazo[1,2-a]pyrazinyl, optionally substituted tetrahydroimidazo[1,2-a]pyrazinyl, optionally substituted dihydr-isoindolyl, optionally substituted 1,2,3,4-tetrahydro-isoquinolinyl, optionally substituted isoquinolinyl, —C(O)— optionally substituted isoxazolyl, —C(O)— optionally substituted oxazolyl, optionally substituted oxetanyl, —C(═O)— optionally substituted phenyl, optionally substituted piperidinyl, —C(O)— optionally substituted piperidinyl, optionally substituted pyrazolyl, —C(O)CH 2 O— optionally substituted pyridazinyl, —C(O)— optionally substituted pyridinyl, optionally substituted pyrimidinyl, optionally substituted quinazolinyl, optionally substituted dihydroquinolinyl, optionally substituted —C(O)-tetrahydrobenzo[b]thiophenyl, —C(O)— optionally substituted tetrahydropyranyl, —C(O)— optionally substituted tetrahydropyridinyl, —C(O)-thiazolyl, —C(O)N(H)-thiazolyl, —C(O)NHCH 2 CN, or —S(O) 2 CH═CH 2 . 
     
     
         15 . The compound according to  claim 14 , wherein X is NR 2  and R 2  is H. 
     
     
         16 . The compound according to  claim 15 , wherein Y is CR 1  and R 1  of Y is optionally substituted with one or more substituents independently selected from halogen, CN, ═O, (C 1 -C 4 )alkyl, (C 2 -C 4 )alkenyl, —CH 2 NH 2 , —CH 2 CH 2 OH, —CH 2 CH(OH)CH 2 CH 3 , —CH 2 CH(OH)CH 2 OH, —CH 2 CH 2 OCH 2 CH 3 , —CH 2 C(OH)(CH 3 ) 2 , —CH 2 NHC(O)(C 1 -C 4 )alkyl, —CH 2 NHC(O)CH 2 Cl, —CH 2 NHC(O)CH 2 CN, —CH 2 NHC(O)CH 2 CH 2 N(CH 3 ) 2 , —CH 2 NHC(O)C(═CH 2 )CH 3 , —CH 2 NHC(O)(C 2 -C 4 )alkynyl, —CH 2 NHC(O)CH 2 CH 2 -piperidinyl, —(C 1 -C 4 )alkyl-morpholinyl, —CH 2 NHC(O)CH 2 O— phenyl wherein the phenyl is optionally substituted with halogen, (C 1 -C 4 )alkoxy, —C(O)(C 1 -C 4 )alkyl, —C(O)(C 1 -C 4 )alkoxy, —C(O)N(H) 2 , —C(O)N(CH 3 ) 2 , —C(O)-morpholinyl, —C(O)-pyrrolidinyl, —N(CH 3 ) 2 , —NHC(O)(C 1 -C 4 )alkyl, —NHC(O)(C 2 -C 4 )alkenyl, —NHC(O)CH 2 CN, —S(O) 2 (C 1 -C 4 )alkyl, —S(O) 2 -pyrrolidinyl, morpholinyl, tetrahydropyranyl, or 4-methylpiperazinecarbonyl. 
     
     
         17 . The compound according to  claim 16 , wherein Z is CR 1  and R 1  of Z is H, (C 1 -C 4 )alkyl, —NHC(O)CH 2 Cl, —NHC(O)CH 2 CN, —NHC(O)(C 2 -C 4 )alkenyl, —NHC(O)(C 2 -C 4 )alkynyl, —NHC(O)C(═CH 2 )CH 3 , —NHC(O)CH 2 -phenyl wherein the phenyl is optionally substituted with halogen, or pyrazolyl substituted with CH 3 . 
     
     
         18 . The compound according to  claim 17 , wherein R 302  is optionally substituted with one or more substituents independently selected from halogen, CF 3 , OCF 3 , ═O, CHF 2 , CN, C(O)OH, OH, (C 1 -C 4 )alkyl, (C 1 -C 4 )alkoxy, (C 3 -C 6 )cycloalkyl, —(C 1 -C 4 )alkylCN, —(C 1 -C 4 )alkylC(O)NH 2 , —C(O)NH 2 , —C(O)N(H)(C 1 -C 4 )alkyl, —C(O)N(C 1 -C 4 )alkyl) 2 , —C(O)N(H)cyclopropyl, —C(O)(C 1 -C 4 )alkoxy, NH 2 , N(H)CH 3 , N(CH 3 ) 2 , or optionally substituted benzyl. 
     
     
         19 . The compound according to  claim 1 , wherein
 X is NR 2  wherein R 2  is H;   Y is CR 1  wherein R 1  is H, CH 3 , substituted pyrazolyl, 6,7-dihydro-4H-pyrazolo[5,1-c][1,4]oxazinyl or tetrahydrofuranyl;   Z is CR 1  wherein R 1  is H;   E is CR 5  wherein R 5  is H;   R 3  is —R 301 -L-R 302  wherein
 R 301  is a bond, —O—, —N(H)—, —N(CH 3 )— or —C(H)(CH 3 )—; 
 L is azetidinyl, 3,6-diazabicyclo[3.2.0]heptanyl, morpholinyl, [1,4]oxepanyl, piperidinyl, or pyrrolidinyl;
 wherein the azetidinyl is optionally substituted with CH 3 ; and 
 wherein the piperidinyl is optionally substituted with —CH 2 OH; and 
 
 R 302  is —C(O)CH═CH 2  or —C(O)C≡CH. 
   
     
     
         20 . The compound according to  claim 1 , wherein the compound is:
 4-((1-acryloylazetidin-3-yl)(methyl)amino)-1H-indole-7-carboxamide;   4-(5-acetylthiophen-2-yl)-2-p-tolyl-1H-indole-7-carboxamide;   4-(1-(4-methoxybenzyl)-1H-pyrazol-5-ylamino)-2-p-tolyl-1H-indole-7-carboxamide;   4-(3-(6-fluoro-4-oxoquinazolin-3(4H)-yl)-2-methylphenyl)-2-(pyridin-3-yl)-1H-indole-7-carboxamide;   4-(3-(6-fluoro-4-oxoquinazolin-3(4H)-yl)-2-methylphenyl)-2-(pyridin-3-yl)-1H-indole-7-carboxamide;   4-(2-methyl-3-(4-oxoquinazolin-3(4H)-yl)phenyl)-2-(pyridin-3-yl)-1H-indole-7-carboxamide;   4-(2-methyl-3-(4,5,6,7-tetrahydrobenzo[b]thiophene-2-carboxamido)phenyl)-2-(pyridin-3-yl)-1H-indole-7-carboxamide;   4-(2-methyl-3-(1-oxoisoindolin-2-yl)phenyl)-2-(pyridin-3-yl)-1H-indole-7-carboxamide;   4-(2-methyl-3-(6-methyl-1-oxoisoindolin-2-yl)phenyl)-2-(pyridin-3-yl)-1H-indole-7-carboxamide;   4-(3-(6-fluoro-1-oxoisoindolin-2-yl)-2-methylphenyl)-2-(pyridin-3-yl)-1H-indole-7-carboxamide;   4-(3-(6-fluoro-1-oxoisoindolin-2-yl)-2-methylphenyl)-2-(4-fluorophenyl)-1H-indole-7-carboxamide;   2-(4-fluorophenyl)-4-(2-methyl-3-(4,5,6,7-tetrahydrobenzo[b]thiophene-2-carboxamido)phenyl)-1H-indole-7-carboxamide;   N-(3-(7-carbamoyl-2-(pyridin-3-yl)-1H-indol-4-yl)-4-methylphenyl)thiazole-2-carboxamide 2,2,2-trifluoroacetate;   N-(3-(7-carbamoyl-2-(pyridin-3-yl)-1H-indol-4-yl)-2-methylphenyl)thiazole-2-carboxamide;   (R)-4-(3-(4-oxoquinazolin-3(4H)-yl)piperidin-1-yl)-1H-indole-7-carboxamide*;   (R)-2-(4-fluorophenyl)-4-(3-(4-oxoquinazolin-3(4H)-yl)piperidin-1-yl)-1H-indole-7-carboxamide*;   (R)-4-(3-(4-oxoquinazolin-3(4H)-yl)piperidin-1-yl)-2-(pyridin-3-yl)-1H-indole-7-carboxamide*;   (R)-2-(1-methyl-1H-pyrazol-4-yl)-4-(3-(4-oxoquinazolin-3 (4H)-yl)piperidin-1-yl)-1H-indole-7-carboxamide*;   (R)-4-(3-(6-fluoro-4-oxoquinazolin-3(4H)-yl)piperidin-1-yl)-2-(4-fluorophenyl)-1H-indole-7-carboxamide*;   2-(1-methyl-1H-pyrazol-4-yl)-4-(2-methyl-3-(4-oxoquinazolin-3(4H)-yl)phenyl)-1H-indole-7-carboxamide;   4-(2-methyl-3-(4-oxoquinazolin-3(4H)-yl)phenyl)-1H-indole-7-carboxamide;   2-(1-acetyl-1,2,3,6-tetrahydropyridin-4-yl)-4-(2-methyl-3-(4-oxoquinazolin-3(4H)-yl)phenyl)-H-indole-7-carboxamide;   (R)-4-(3-(4-tert-butylbenzamido)piperidin-1-yl)-2-(pyridin-3-yl)-1H-indole-7-carboxamide*;   (R)-4-(3-(4-tert-butylbenzamido)piperidin-1-yl)-1H-indole-7-carboxamide*;   (R)—N-(1-(7-carbamoyl-1H-indol-4-yl)piperidin-3-yl)-2-methyloxazole-3-carboxamide*;   (R)-4-(3-(3-thiazol-2-ylureido)piperidin-1-yl)-1H-indole-7-carboxamide*;   4-(3-(4-tert-butylbenzamido)-2-methylphenyl)-1H-indole-7-carboxamide;   4-(3-(7-cyclopropyl-5-fluoro-4-oxoquinazolin-3(4TH-yl)piperidin-1-yl)-1H-indole-7-carboxamide;   (R)-4-(3-(4-tert-butylbenzamido)piperidin-1-yl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-indole-7-carboxamide*;   (R)-4-(3-(4-methoxybenzamido)piperidin-1-yl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-indole-7-carboxamide*;   (R)-5-tert-butyl-N-(1-(7-carbamoyl-1H-indol-4-yl)piperidin-3-yl)isoxazole-3-carboxamide*;   (R)-2-(1-methyl-1H-pyrazol-4-yl)-4-(3-(4-(trifluoromethyl)benzamido)piperidin-1-yl)-1H-indole-7-carboxamide*;   (R)-4-(3-(4-methoxybenzamido)piperidin-1-yl)-1H-indole-7-carboxamide*;   (R)-4-(3-(4-(trifluoromethyl)benzamido)piperidin-1-yl)-1H-indole-7-carboxamide*;   (R)-4-(3-(4-(difluoromethyl)benzamido)piperidin-1-yl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-indole-7-carboxamide*;   4-(3-(6-fluoro-4-oxoquinazolin-3 (4H)-yl)-2-methylphenyl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-indole-7-carboxamide;   2-(3,6-dihydro-2H-pyran-4-yl)-4-(2-methyl-3-(4-oxoquinazolin-3(4TH-yl)phenyl)-1H-indole-7-carboxamide;   2-(4-fluorophenyl)-4-(2-methyl-3-(4-oxoquinazolin-3 (4H)-yl)phenyl)-1H-indole-7-carboxamide;   (R)-4-(3-(4-(1-amino-2-methyl-1-oxopropan-2-yl)benzamido)piperidin-1-yl)-2-(1-methyl-1H-pyrazol-4-yl-1H-indole-carboxamide*;   (R)-2-(1-methyl-1H-pyrazol-4-yl)-4-(3-(4-(trifluoromethoxy)benzamido)piperidin-1-yl)-1H-indole-7-carboxamide*;   2-(1-(2-hydroxyethyl)-1H-pyrazol-4-yl)-4-(2-methyl-3-(4-oxoquinazolin-3(4TH-yl)phenyl)-1H-indole-7-carboxamide;   (R)-4-(3-(6-fluoro-1-oxoisoindolin-2-yl)piperidin-1-yl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-indole-7-carboxamide*;   2-(3,6-dihydro-2H-pyran-4-yl)-4-(3-(6-fluoro-4-oxoquinazolin-3 (4H)-yl)-2-methylphenyl)-1H-indole-7-carboxamide;   2-(1-acetyl-1,2,3,6-tetrahydropyridin-4-yl)-4-(3-(6-fluoro-4-oxoquinazolin-3(4H)-yl)-2-methylphenyl)-1H-indole-7-carboxamide;   N-(3-(7-carbamoyl-2-(1-methyl-1H-pyrazol-4-yl)-1H-indol-4-yl)-2-methylphenyl)thiazole-2-carboxamide;   4-(3-(6-fluoro-4-oxoquinazolin-3(4H)-yl)-2-(hydroxymethyl)phenyl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-indole-7-carboxamide;   2-(1-methyl-1H-pyrazol-4-yl)-4-(2-methyl-3-(4,5,6,7-tetrahydrobenzo[b]thiophene-2-carboxamido)phenyl)-1H-indole-7-carboxamide;   (R)-4-(3-(4-cyclopropylbenzamido)piperidin-1-yl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-indole-7-carboxamide*;   2-(2,5-dihydro-1H-pyrrol-3-yl)-4-(2-methyl-3-(4-oxoquinazolin-3(4H)-yl)phenyl)-1H-indole-7-carboxamide;   4-(2-methyl-3-(4-oxoquinazolin-3(4H)-yl)phenyl)-2-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-7-carboxamide;   2-(1-((R)-2,3-dihydroxypropyl)-1H-pyrazol-4-yl)-4-(2-methyl-3-(4-oxoquinazolin-3(4H)-yl)phenyl)-1H-indole-7-carboxamide*;   N-(3-(7-carbamoyl-2-(1-methyl-1H-pyrazol-4-yl)-1H-indol-4-yl)-2-(hydroxymethyl)phenyl)thiazole-2-carboxamide;   2-(1-acetyl-1,2,3,6-tetrahydropyridin-4-yl)-4-(3-(4-tert-butylbenzamido)-2-methylphenyl)-1H-indole-7-carboxamide;   N-(3-(2-(1-acetyl-1,2,3,6-tetrahydropyridin-4-yl)-7-carbamoyl-1H-indol-4-yl)-2-methylphenyl)thiazole-2-carboxamide;   2-(1-acetyl-1,2,3,6-tetrahydropyridin-4-yl)-4-(2-methyl-3-(4,5,6,7-tetrahydrobenzo[b]thiophene-2-carboxamido)phenyl)-1H-indole-7-carboxamide;   2-(1-acetyl-1,2,3,6-tetrahydropyridin-4-yl)-4-(3-(4-cyclopropylbenzamido)-2-methylphenyl)-1H-indole-7-carboxamide;   4-(2-methyl-3-(1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)phenyl)-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-7-carboxamide;   2-(1-methyl-2,5-dihydro-1H-pyrrol-3-yl)-4-(2-methyl-3-(4-oxoquinazolin-3(4H)-yl)phenyl)-1H-indole-7-carboxamide;   2-(1-acetyl-2,5-dihydro-1H-pyrrol-3-yl)-4-(2-methyl-3-(4-oxoquinazolin-3(4H)-yl)phenyl)-H-indole-7-carboxamide;   ethyl 3-(7-carbamoyl-4-(2-methyl-3-(4-oxoquinazolin-3(4H)-yl)phenyl)-1H-indol-2-yl)-2,5-dihydro-1H-pyrrole-1-carboxylate;   2-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-4-(2-methyl-3-(4-oxoquinazolin-3(4H)-yl)phenyl)-1H-indole-7-carboxamide;   4-(2-methyl-3-(4-oxoquinazolin-3(4H)-yl)phenyl)-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-7-carboxamide;   N-(3-(7-carbamoyl-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-4-yl)-2-methylphenyl)thiazole-2-carboxamide;   N-(3-(7-carbamoyl-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-4-yl)-2-methylphenyl)thiazole-2-carboxamide;   2-(1-((S)-2,3-dihydroxypropyl)-1H-pyrazol-4-yl)-4-(2-methyl-3-(4-oxoquinazolin-3(4H)-yl)phenyl)-1H-indole-7-carboxamide;   N-(3-(7-carbamoyl-2-(1-methyl-1H-pyrazol-4-yl)-1H-indol-4-yl)-2-methylphenyl)-N-methylthiazole-2-carboxamide;   N-(3-(7-carbamoyl-2-(1-methyl-1H-pyrazol-4-yl)-1H-indol-4-yl)-2-methylphenyl)-N-(oxetan-3-yl)thiazole-2-carboxamide;   2-(1-acetyl-1,2,3,6-tetrahydropyridin-4-yl)-4-(3-(4-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)-1H-indole-7-carboxamide;   4-(2-methyl-3-(4-oxoquinazolin-3(4H)-yl)phenyl)-2-(pyrimidin-5-yl)-1H-indole-7-carboxamide;   4-(3-(6-fluoro-4-oxoquinazolin-3(4H)-2-methylphenyl)-2-(pyrimidin-5-yl)-1H-indole-7-carboxamide;   4-(3-(4-(difluoromethyl)benzamido)-2-methylphenyl)-2-(pyrimidin-5-yl)-1H-indole-7-carboxamide;   4-(3-(4-cyclopropylbenzamido)-2-methylphenyl)-2-(pyrimidin-5-yl)-1H-indole-7-carboxamide;   4-(3-(6-fluoro-4-oxoquinazolin-3(4H)-yl)-2-methylphenyl)-2-(1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl)-1H-indole-7-carboxamide;   (R)-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-4-(3-(8-oxo-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)piperidin-1-yl)-1H-indole-7-carboxamide*;   (R)-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-4-(3-(8-oxoimidazo[1,2-a]pyrazin-7(8H)-yl)piperidin-1-yl)-1H-indole-7-carboxamide*;   4-(2-methyl-3-(oxetan-3-ylamino)phenyl)-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-7-carboxamide;   4-(2-methyl-3-(1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)phenyl)-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-7-carboxamide;   4-(3-(4-(difluoromethyl)benzamido)-2-methylphenyl)-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-7-carboxamide;   4-(3-(4-hydroxy-4-(trifluoromethyl)cyclohexanecarboxamido)-2-methylphenyl)-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-7-carboxamide;   (R)-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-4-(3-(1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)piperidin-1-yl)-1H-indole-7-carboxamide*;   2-(1-acetylpiperidin-4-yl)-4-(3-(4-cyclopropylbenzamido)-2-methylphenyl)-H-indole-7-carboxamide;   (R)—N-(1-(7-carbamoyl-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-4-yl)piperidin-3-yl)-2-methyloxazole-4-carboxamide*;   (R)-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-4-(2-oxo-1,3‘-bipiperidin-’-yl)-1H-indole-7-carboxamide*;   2-(1-methyl-1H-pyrazol-4-yl)-4-(2-methyl-3-(4-oxoquinazolin-3(4H)-yl)phenyl)-1H-benzo[d]imidazole-7-carboxamide;   4-(3-(4-(difluoromethyl)-N-(oxetan-3-yl)benzamido)-2-methylphenyl)-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-7-carboxamide;   4-(2-methyl-3-(oxetan-3-ylamino)phenyl)-1H-indole-7-carboxamide;   4-(3-(4-(difluoromethyl)benzamido)-2-methylphenyl)-1H-indole-7-carboxamide;   4-(3-(2-hydroxyethylamino)-2-methylphenyl)-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-7-carboxamide;   (R)—N-(1-(7-carbamoyl-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-4-yl)piperidin-3-yl)thiazole-2-carboxamide*;   4-(3-(cyclohexanecarboxamido)-2-methylphenyl)-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-7-carboxamide;   4-(3-(4-(difluoromethyl)-N-(2-hydroxyethyl)benzamido)-2-methylphenyl)-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-7-carboxamide;   N-(3-(7-carbamoyl-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-4-yl)-2-methylphenyl)isothiazole-4-carboxamide;   4-(2-methyl-3-(tetrahydro-2H-pyran-4-carboxamido)phenyl)-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-7-carboxamide;   4-(2-methyl-3-(1-methylpiperidine-3-carboxamido)phenyl)-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-7-carboxamide;   4-(2-methyl-3-(1-methylpiperidine-4-carboxamido)phenyl)-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-7-carboxamide;   4-(3-(cyclopentanecarboxamido)-2-methylphenyl)-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-7-carboxamide;   N-(3-(7-carbamoyl-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-4-yl)-2-methylphenyl)-2-methylthiazole-4-carboxamide;   4-(3-(3-methoxycyclohexanecarboxamido)-2-methylphenyl)-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-7-carboxamide;   4-(2-methyl-3-(3-methylbutanamido)phenyl)-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-7-carboxamide;   4-(3-isobutyramido-2-methylphenyl)-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-7-carboxamide;   4-(2-methyl-3-(nicotinamido)phenyl)-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-7-carboxamide;   4-(3-acrylamido-2-methylphenyl)-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-7-carboxamide;   N-(3-(7-carbamoyl-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-4-yl)-2-methylphenyl)-5-methylthiazole-2-carboxamide;   N-(3-(7-carbamoyl-2-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-1H-indol-4-yl)-2-methylphenyl)thiazole-2-carboxamide;   N-((3R,4R)-1-(7-carbamoyl-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-4-yl)-4-hydroxypiperidin-3-yl)thiazole-2-carboxamide;   (R)-4-(3-acrylamidopiperidin-1-yl)-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-7-carboxamide*;   4-(2-methyl-3-(thiazol-2-ylmethylamino)phenyl)-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-7-carboxamide;   4-(2-methyl-3-(N-(thiazol-2-ylmethyl)acrylamido)phenyl)-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-7-carboxamide;   (Z)-4-(2-methyl-3-(2-methylbut-2-enamido)phenyl)-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-7-carboxamide;   (E)-4-(3-(4-(dimethylamino)but-2-enamido)-2-methylphenyl)-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-7-carboxamide;   4-(2-methyl-3-(3-(piperidin-1-yl)propanamido)phenyl)-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-7-carboxamide;   4-(3-(2-cyanoacetamido)-2-methylphenyl)-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-7-carboxamide;   4-(2-methyl-3-propionamidophenyl)-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-7-carboxamide;   4-(3-methacrylamido-2-methylphenyl)-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-7-carboxamidel;   4-(3-(2-chloro-2,2-difluoroacetamido)-2-methylphenyl)-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-7-carboxamide;   4-(3-(2-chloropropanamido)-2-methylphenyl)-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-7-carboxamide;   (E)-4-(3-but-2-enamido-2-methylphenyl)-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-7-carboxamide;   N1-(3-(7-carbamoyl-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-4-yl)-2-methylphenyl);   4-(3-(2-(4-fluorophenoxy)acetamido)-2-methylphenyl)-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-7-carboxamide;   4-(2-methyl-3-(3-(pyrrolidin-1-yl)propanamido)phenyl)-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-7-carboxamide;   4-(3-(2-(4-cyanophenoxy)acetamido)-2-methylphenyl)-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-7-carboxamide;   4-(2-methyl-3-(2-(pyridin-3-yloxy)acetamido)phenyl)-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-7-carboxamide;   4-(3-(cyclopent-1-enecarboxamido)-2-methylphenyl)-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-7-carboxamide;   (E)-4-(2-methyl-3-(2-methylpent-2-enamido)phenyl)-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-7-carboxamide;   (Z)-4-(3-(3-chloroacrylamido)-2-methylphenyl)-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-7-carboxamide;   (E)-methyl 4-(3-(7-carbamoyl-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-4-yl)-2-methylphenylamino)-4-oxobut-2-enoate;   4-(3-(cyclohex-1-enecarboxamido)-2-methylphenyl)-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-7-carboxamide;   (E)-ethyl 4-(3-(7-carbamoyl-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-4-yl)-2-methylphenylamino)-4-oxobut-2-enoate;   4-(2-methyl-3-(2-phenoxyacetamido)phenyl)-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-7-carboxamide;   4-(3-(2-fluoroacetamido)-2-methylphenyl)-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-7-carboxamide;   4-(3-acrylamido-2-methylphenyl)-2-(4,4-difluorocyclohex-1-enyl)-1H-indole-7-carboxamide;   4-(2-(acrylamidomethyl)phenyl)-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-7-carboxamide;   4-(3-(3-(dimethylamino)propanamido)-2-methylphenyl)-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-7-carboxamide;   4-(2-acrylamidophenyl)-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-7-carboxamide;   4-(3-(acrylamidomethyl)phenyl)-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-7-carboxamide;   4-(3-(acrylamidomethyl)phenyl)-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-7-carboxamide;   4-(3-(2-cyanopyrimidin-4-ylamino)phenyl)-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-7-carboxamide;   4-(3-(6-cyclopropyl-8-fluoro-1-oxoisoquinolin-2(1H)-yl)-2-(hydroxymethyl)phenyl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-indole-7-carboxamide;   4-(3-acrylamidophenyl)-1H-indole-7-carboxamide;   4-(3-acrylamido-2-methylphenyl)-1H-indole-7-carboxamide;   4-(3-acrylamido-2-methylphenyl)-2-(2-methoxypyridin-3-yl)-1H-indole-7-carboxamide;   4-(2-methyl-3-(2-(pyridin-2-yloxy)acetamido)phenyl)-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-7-carboxamide;   N1-(3-(7-carbamoyl-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-4-yl)-2-methylphenyl)fumaramide;   4-(3-(2-chlorobutanamido)-2-methylphenyl)-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-7-carboxamide;   4-(2-methyl-3-(3-(4-methylpiperazin-1-yl)propanamido)phenyl)-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-7-carboxamide;   4-(2-methyl-3-(2-(pyridazin-3-yloxy)acetamido)phenyl)-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-7-carboxamide;   2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-4-(3-(thiazol-2-ylmethoxy)phenyl)-1H-indole-7-carboxamide;   methyl 3-(4-(3-acrylamido-2-methylphenyl)-7-carbamoyl-1H-indol-2-yl)benzoate;   4-(3-acrylamido-2-methylphenyl)-2-(3-methoxyphenyl)-1H-indole-7-carboxamide;   4-(3-acrylamido-2-methylphenyl)-2-(4-methoxyphenyl)-1H-indole-7-carboxamide;   4-(3-acrylamido-2-methylphenyl)-2-(6-methylpyridin-3-yl)-1H-indole-7-carboxamide;   4-(3-acrylamido-2-methylphenyl)-2-(3-carbamoylphenyl)-1H-indole-7-carboxamide;   N-(3-(7-carbamoyl-3-methyl-1H-indol-4-yl)-2-methylphenyl)thiazole-2-carboxamide;   4-(3-acrylamido-2-methylphenyl)-2-(3,5-dimethylisoxazol-4-yl)-1H-indole-7-carboxamide;   4-(3-acrylamido-2-methylphenyl)-2-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-5-yl)-1H-indole-7-carboxamide;   4-(3-acrylamido-2-methylphenyl)-2-(3,5-dimethyl-1H-pyrazol-4-yl)-1H-indole-7-carboxamide;   4-(3-acrylamido-2-methylphenyl)-2-(1-isopropyl-1H-pyrazol-4-yl)-1H-indole-7-carboxamide;   4-(3-acrylamido-2-methylphenyl)-2-(1,3-dimethyl-1H-pyrazol-4-yl)-1H-indole-7-carboxamide;   4-(3-acrylamido-2-methylphenyl)-2-(1-ethyl-1H-pyrazol-4-yl)-1H-indole-7-carboxamide;   4-(3-acrylamido-2-methylphenyl)-2-(1-isobutyl-1H-pyrazol-4-yl)-1H-indole-7-carboxamide;   (E)-N-(3-(3-but-2-enamido-7-carbamoyl-1H-indol-4-yl)-2-methylphenyl)thiazole-2-carboxamide;   N-(3-(7-carbamoyl-3-methacrylamido-1H-indol-4-yl)-2-methylphenyl)thiazole-2-carboxamide;   N-(3-(3-but-2-ynamido-7-carbamoyl-1H-indol-4-yl)-2-methylphenyl)thiazole-2-carboxamide;   N-(3-(7-carbamoyl-3-(2-(4-fluorophenoxy)acetamido)-1H-indol-4-yl)-2-methylphenyl)thiazole-2-carboxamide;   4-(3-acrylamido-2-methylphenyl)-2-(2-fluoropyridin-3-yl)-1H-indole-7-carboxamide;   4-(3-acrylamido-2-methylphenyl)-2-(1-ethyl-1H-pyrazol-4-yl)-1H-indole-7-carboxamide;   2-(3-acetamidophenyl)-4-(3-acrylamido-2-methylphenyl)-1H-indole-7-carboxamide;   4-(3-acrylamido-2-methylphenyl)-2-(2-methoxypyridin-4-yl)-1H-indole-7-carboxamide;   4-(3-acrylamido-2-methylphenyl)-2-(3-cyanophenyl)-1H-indole-7-carboxamide;   methyl 4-(4-(3-acrylamido-2-methylphenyl)-7-carbamoyl-1H-indol-2-yl)benzoate;   4-(3-acrylamido-2-methylphenyl)-2-(2,3-dihydrobenzofuran-5-yl)-1H-indole-7-carboxamide;   4-(3-acrylamido-2-methylphenyl)-2-(3-fluorophenyl)-1H-indole-7-carboxamide;   4-(3-acrylamido-2-methylphenyl)-2-(3-(dimethylamino)phenyl)-1H-indole-7-carboxamide;   4-(2-(2-chloroacetamido)phenyl)-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-7-carboxamide;   4-(2-acetamidophenyl)-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-7-carboxamide;   4-(3-acrylamido-2-methylphenyl)-2-(2-methyl-5-(pyrrolidin-1-ylsulfonyl)phenyl)-1H-indole-7-carboxamide;   4-(3-acrylamido-2-methylphenyl)-2-(2-fluorophenyl)-1H-indole-7-carboxamide;   N-(3-(3-acrylamido-7-carbamoyl-1H-indol-4-yl)-2-methylphenyl)thiazole-2-carboxamide;   N-(3-(7-carbamoyl-3-(2-chloroacetamido)-1H-indol-4-yl)-2-methylphenyl)thiazole-2-carboxamide;   4-(3-acrylamido-2-methylphenyl)-2-(1-methyl-1H-pyrazol-5-yl)-H-indole-7-carboxamide;   4-(3-acrylamido-2-methylphenyl)-2-(pyridin-4-yl)-1H-indole-7-carboxamide;   4-(3-acrylamido-2-methylphenyl)-2-(1-(2-morpholinoethyl)-1H-pyrazol-4-yl)-1H-indole-7-carboxamide;   4-(3-acrylamido-2-methylphenyl)-2-(6-morpholinopyridin-3-yl)-H-indole-7-carboxamide;   4-(3-acrylamido-2-methylphenyl)-2-(3-(4-methylpiperazine-1-carbonyl)phenyl)-1H-indole-7-carboxamide;   N-(3-(2-(2-(acrylamidomethyl)phenyl)-7-carbamoyl-1H-indol-4-yl)-2-methylphenyl)thiazole-2-carboxamide;   N-(3-(2-(2-(acetamidomethyl)phenyl)-7-carbamoyl-1H-indol-4-yl)-2-methylphenyl)thiazole-2-carboxamide;   N-(3-(7-carbamoyl-2-(2-(propionamidomethyl)phenyl)-1H-indol-4-yl)-2-methylphenyl)thiazole-2-carboxamide;   N-(3-(2-(2-(butyramidomethyl)phenyl)-7-carbamoyl-1H-indol-4-yl)-2-methylphenyl)thiazole-2-carboxamide;   (E)-N-(3-(2-(2-(but-2-enamidomethyl)phenyl)-7-carbamoyl-1H-indol-4-yl)-2-methylphenyl)thiazole-2-carboxamide;   N-(3-(7-carbamoyl-2-(2-(methacrylamidomethyl)phenyl)-1H-indol-4-yl)-2-methylphenyl)thiazole-2-carboxamide;   N-(3-(7-carbamoyl-2-(2-(propiolamidomethyl)phenyl)-1H-indol-4-yl)-2-methylphenyl)thiazole-2-carboxamide;   N-(3-(2-(2-(but-2-ynamidomethyl)phenyl)-7-carbamoyl-1H-indol-4-yl)-2-methylphenyl)thiazole-2-carboxamide;   N-(3-(7-carbamoyl-2-(2-((2-cyanoacetamido)methyl)phenyl)-1H-indol-4-yl)-2-methylphenyl)thiazole-2-carboxamide;   N-(3-(7-carbamoyl-2-(2-((3-(dimethylamino)propanamido)methyl)phenyl)-1H-indol-4-yl)-2-methylphenyl)thiazole-2-carboxamide;   N-(3-(7-carbamoyl-2-(2-((3-(piperidin-1-yl)propanamido)methyl)phenyl)-1H-indol-4-yl)-2-methylphenyl)thiazole-2-carboxamide;   N-(3-(7-carbamoyl-2-(2-((2-phenoxyacetamido)methyl)phenyl)-1H-indol-4-yl)-2-methylphenyl)thiazole-2-carboxamide;   N-(3-(7-carbamoyl-2-(2-((2-(4-fluorophenoxy)acetamido)methyl)phenyl)-1H-indol-4-yl)-2-methylphenyl)thiazole-2-carboxamide;   N-(3-(7-carbamoyl-2-(2-((2-chloroacetamido)methyl)phenyl)-1H-indol-4-yl)-2-methylphenyl)thiazole-2-carboxamide;   N-(3-(2-(2-(aminomethyl)phenyl)-7-carbamoyl-1H-indol-4-yl)-2-methylphenyl)thiazole-2-carboxamide;   4-(3-acrylamido-2-methylphenyl)-2-(4-fluorophenyl)-1H-indole-7-carboxamide;   4-(3-acrylamido-2-methylphenyl)-2-phenyl-1H-indole-7-carboxamide;   4-(3-acrylamido-2-methylphenyl)-2-(2-(methylsulfonyl)phenyl)-1H-indole-7-carboxamide;   4-(3-acrylamido-2-methylphenyl)-2-(4-(dimethylcarbamoyl)phenyl)-1H-indole-7-carboxamide;   4-(3-acrylamido-2-methylphenyl)-2-(pyrimidin-5-yl)-1H-indole-7-carboxamide;   4-(3-acrylamido-2-methylphenyl)-2-(pyridin-3-yl)-1H-indole-7-carboxamide;   4-(3-acrylamido-2-methylphenyl)-2-(4-(morpholine-4-carbonyl)phenyl)-1H-indole-7-carboxamide;   4-(3-acrylamido-2-methylphenyl)-2-(4-(pyrrolidine-1-carbonyl)phenyl)-1H-indole-7-carboxamide;   4-(3-acrylamido-2-methylphenyl)-2-(4-(4-methylpiperazine-1-carbonyl)phenyl)-1H-indole-7-carboxamide;   4-(3-acrylamido-2-methylphenyl)-2-(4-(methylsulfonyl)phenyl)-1H-indole-7-carboxamide;   4-(3-acrylamido-2-methylphenyl)-2-(6-methoxypyridin-3-yl)-1H-indole-7-carboxamide;   4-(3-acrylamido-2-methylphenyl)-2-(4-cyanophenyl)-1H-indole-7-carboxamide;   4-(3-acrylamido-2-methylphenyl)-2-(2-methoxyphenyl)-1H-indole-7-carboxamide;   N-(3-(7-carbamoyl-3-(2-cyanoacetamido)-1H-indol-4-yl)-2-methylphenyl)thiazole-2-carboxamide;   4-(2-acrylamidophenyl)-1H-indole-7-carboxamide;   4-(3-acrylamido-2-methylphenyl)-2-(4-(morpholinomethyl)phenyl)-1H-indole-7-carboxamide;   4-(3-acrylamido-2-methylphenyl)-2-(4-carbamoylphenyl)-1H-indole-7-carboxamide;   4-(3-acrylamido-5-(thiazol-2-ylmethylamino)phenyl)-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-7-carboxamide;   4-(2-methyl-3-(N-methylacrylamido)phenyl)-1H-indole-7-carboxamide;   4-(3-(methylamino)phenyl)-1H-indole-7-carboxamide;   4-(3-(N-methylacrylamido)phenyl)-1H-indole-7-carboxamide;   4-(2-methyl-3-(2-methylenebutanamido)phenyl)-1H-indole-7-carboxamide;   4-(2-methyl-3-(3-(pyrrolidin-1-yl)propanamido)phenyl)-1H-indole-7-carboxamide;   4-(3-methacrylamido-2-methylphenyl)-1H-indole-7-carboxamide;   (E)-4-(3-(3-cyclopropylacrylamido)-2-methylphenyl)-1H-indole-7-carboxamide;   (E)-4-(2-methyl-3-(3-(pyridin-2-yl)acrylamido)phenyl)-1H-indole-7-carboxamide;   (E)-4-(2-methyl-3-(3-(1-methyl-1H-pyrazol-4-yl) acrylamido)phenyl)-1H-indole-7-carboxamide;   (E)-ethyl 4-(3-(7-carbamoyl-1H-indol-4-yl)-2-methylphenylamino)-4-oxobut-2-enoate;   (E)-4-(3-(4-(dimethylamino)but-2-enamido)-2-methylphenyl)-1H-indole-7-carboxamide;   (E)-4-(2-methyl-3-(3-(pyridin-3-yl)acrylamido)phenyl)-1H-indole-7-carboxamide;   (E)-4-(2-methyl-3-(4-methylpent-2-enamido)phenyl)-1H-indole-7-carboxamide;   N1-(3-(7-carbamoyl-1H-indol-4-yl)-2-methylphenyl)-N4-ethylmaleamide;   4-(3-acetamido-2-methylphenyl)-1H-indole-7-carboxamide;   (E)-4-(3-but-2-enamido-2-methylphenyl)-1H-indole-7-carboxamide;   4-(2-methyl-3-(3-morpholinopropanamido)phenyl)-1H-indole-7-carboxamide;   (E)-4-(2-methyl-3-(3-(thiazol-2-yl)acrylamido)phenyl)-1H-indole-7-carboxamide;   4-(2-methyl-3-(2-phenylacrylamido)phenyl)-1H-indole-7-carboxamide;   (E)-4-(2-methyl-3-(4-(piperidin-1-yl)but-2-enamido)phenyl)-1H-indole-7-carboxamide;   (E)-4-(2-methyl-3-(4-((tetrahydrofuran-2-yl)methylamino) but-2-enamido)phenyl)-1H-indole-7-carboxamide;   (E)-4-(3-(4-(2-methoxyethylamino)but-2-enamido)-2-methylphenyl)-1H-indole-7-carboxamide;   (E)-4-(3-(4-(cyclopropylamino)but-2-enamido)-2-methylphenyl)-1H-indole-7-carboxamide;   (E)-4-(2-methyl-3-(4-morpholinobut-2-enamido)phenyl)-1H-indole-7-carboxamide;   (E)-4-(2-methyl-3-(4-(4-methylpiperazin-1-yl)but-2-enamido)phenyl)-1H-indole-7-carboxamide;   4-(3-acrylamido-4-(benzyloxy)phenyl)-1H-indole-7-carboxamide;   4-(3-acrylamido-5-(benzyloxy)phenyl)-1H-indole-7-carboxamide;   4-(3-acrylamido-4-(thiazol-2-ylmethoxy)phenyl)-1H-indole-7-carboxamide;   4-(3-acrylamido-5-(thiazol-2-ylmethoxy)phenyl)-1H-indole-7-carboxamide;   4-(2-acrylamido-4-(thiazol-2-ylmethoxy)phenyl)-1H-indole-7-carboxamide;   4-(3-acrylamido-2-methylphenyl)-1H-pyrrolo[2,3-c]pyridine-7-carboxamide;   4-(2-acrylamido-4-(benzyloxy)phenyl)-1H-indole-7-carboxamide;   4-(5-acrylamidopyridin-3-yl)-1H-indole-7-carboxamide;   4-(2-acrylamidopyridin-4-yl)-1H-indole-7-carboxamide;   N1-(3-(7-carbamoyl-1H-indol-4-yl)phenyl)-N4-(2-methoxyethyl)maleamide;   N1-(3-(7-carbamoyl-1H-indol-4-yl)phenyl)-N4-ethylmaleamide;   4-(3-(1-methyl-1,2, 5,6-tetrahydropyridine-3-carboxamido)phenyl)-1H-indole-7-carboxamide;   4-(3-(vinylsulfonamido)phenyl)-1H-indole-7-carboxamide;   4-(3-(2-oxopropanamido)phenyl)-1H-indole-7-carboxamide;   (E)-methyl 4-(3-(7-carbamoyl-1H-indol-4-yl)phenylamino)-4-oxobut-2-enoate;   4-(3-(cyanomethylcarbamoyl)phenyl)-1H-indole-7-carboxamide;   N-(3-(7-carbamoyl-1H-indol-4-yl)phenyl)-5-methylisoxazole-4-carboxamide;   N1-(3-(7-carbamoyl-1H-indol-4-yl)phenyl)-N4-methylfumaramide;   N1-(3-(7-carbamoyl-1H-indol-4-yl)phenyl)-N4,N4-dimethylfumaramide;   N1-(3-(7-carbamoyl-1H-indol-4-yl)phenyl)-N4-ethylfumaramide;   N1-(3-(7-carbamoyl-1H-indol-4-yl)phenyl)-N4-cyclopropylfumaramide;   (E)-4-(3-(7-carbamoyl-1H-indol-4-yl)phenylamino)-4-oxobut-2-enoic acid;   4-(3-(N-isobutylacrylamido)phenyl)-1H-indole-7-carboxamide;   1-Acryloyl-1,2,3,6-tetrahydro-pyrrolo[2,3-e]indole-5-carboxylic acid amide;   4-acrylamido-1H-indole-7-carboxamide;   4-(3-(N-(cyanomethyl) sulfamoyl)phenyl)-1H-indole-7-carboxamide;   4-(3-acrylamidophenyl)-1H-pyrrolo[3,2-c]pyridine-7-carboxamide;   4-(3-acrylamido-2-methylphenyl)-1H-pyrrolo[3,2-c]pyridine-7-carboxamide;   4-(3-((2-oxopropanamido)methyl)phenyl)-1H-indole-7-carboxamide;   4-(3-acrylamidophenyl)-1H-indazole-7-carboxamide;   4-(3-acrylamido-2-methoxyphenyl)-1H-indole-7-carboxamide;   4-(3-acrylamido-2-fluorophenyl)-1H-indole-7-carboxamide;   4-(5-acrylamido-2-fluorophenyl)-1H-indole-7-carboxamide;   4-(3-acrylamido-4-fluorophenyl)-1H-indole-7-carboxamide;   4-(5-acrylamido-2-chlorophenyl)-1H-indole-7-carboxamide;   4-(5-acrylamido-2,4-difluorophenyl)-1H-indole-7-carboxamide;   4-(3-acrylamido-4-cyanophenyl)-1H-indole-7-carboxamide;   4-(3-acrylamido-2, 6-difluorophenyl)-1H-indole-7-carboxamide;   4-(3-acrylamido-5-methyiphenyl)-1H-indole-7-carboxamide;   4-(3-acrylamido-4-methylphenyl)-1H-indole-7-carboxamide;   4-(3-acrylamido-4-methoxyphenyl)-1H-indole-7-carboxamide;   4-(3-acrylamido-5-methoxyphenyl)-1H-indole-7-carboxamide;   4-(3-acrylamido-4-chlorophenyl)-1H-indole-7-carboxamide;   4-(5-acrylamido-2, 3-difluorophenyl)-1H-indole-7-carboxamide;   4-(3-acrylamido-5-cyanophenyl)-1H-indole-7-carboxamide;   4-(3-acrylamido-2-cyanophenyl)-1H-indole-7-carboxamide;   4-(3-acrylamidophenyl)-2-vinyl-1H-indole-7-carboxamide;   4-(3-acrylamidophenyl)-2-ethyl-1H-indole-7-carboxamide;   4-(3-(2-(morpholinomethyl) acrylamido)phenyl)-1H-indole-7-carboxamide;   4-(3-(2-((dimethylamino)methyl)acrylamido)phenyl)-1H-indole-7-carboxamide;   (E)-4-(3-(4-(dimethylamino)but-2-enamido)-2-methylphenyl)-1H-pyrrolo[2,3-c]pyridine-7-carboxamide;   4-((1R,3S)-3-acrylamidocyclohexyl)-1H-indole-7-carboxamide;   4-(cis-3-acrylamidocyclohexyl)-1H-indole-7-carboxamide;   4-((1S,3S)-3-acrylamidocyclohexyl)-1H-indole-7-carboxamide;   4-(trans-3-acrylamidocyclohexyl)-1H-indole-7-carboxamide;   4-(cis-3-acrylamidocyclohexyl)-1H-indole-7-carboxamide;   4-(3-(2-(aminomethyl)acrylamido)phenyl)-1H-indole-7-carboxamide;   4-((1R,3S)-3-acrylamidocyclopentyl)-1H-indole-7-carboxamide;   4-(3-(2-((methylamino)methyl)acrylamido)phenyl)-1H-indole-7-carboxamide;   4-(3-acrylamidophenyl)-2-methyl-1H-indole-7-carboxamide;   4-((1S,3S)-3-acrylamidocyclopentyl)-1H-indole-7-carboxamide;   4-(3-acrylamidophenyl)-2-(2-ethoxyethyl)-1H-indole-7-carboxamide;   4-(3-acrylamidophenyl)-2-(2-hydroxyethyl)-1H-indole-7-carboxamide;   4-(1-acryloylpiperidin 3-yl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-indole-7-carboxamide;   4-(3-acrylamido-2-methylphenyl)-2-(1-isopropyl-1H-pyrazol-4-yl)-1H-indole-7-carboxamide;   4-(3-(4-cyclopropylbenzamido)-2-methylphenyl)-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-7-carboxamide;   4-(2-methyl-3-(1-methylpiperidine-4-carboxamido)phenyl)-2-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-7-carboxamide;   4-(3-(N-(cyclopentylmethyl)acrylamido)phenyl)-1H-indole-7-carboxamide;   ethyl 4-(7-carbamoyl-4-(2-methyl-3-(4-oxoquinazolin-3(4H)-yl)phenyl)-1H-indol-2-yl)5,6-dihydropyridine-1 (2H)-carboxylate;   (R)-4-(3-(4-oxoquinazolin-3(4H)-yl)piperidin-1-yl)-1H-indole-7-carbonitrile;   4-(2,6-dichlorobenzyl)-2-(p-tolyl)-1H-indole-7-carboxamide;   (E)-4-(3-(2-cyano-3-hydroxybut-2-enamido)phenyl)-1H-indole-7-carboxamide;   4-(cis-3-acrylamidocyclopentyl)-1H-indole-7-carboxamide;   4-(trans-3-acrylamidocyclopentyl)-1H-indole-7-carboxamide;   4-(trans-3-acrylamidocyclopentyl)-1H-indole-7-carboxamide;   4-((1-acryloylazetidin-3-yl)oxy)-1H-indole-7-carboxamide;   (S)-4-(1-(1-acryloylazetidin-3-yl)ethyl)-1H-indole-7-carboxamide*;   (R)-4-(1-(1-acryloylazetidin-3-yl)ethyl)-1H-indole-7-carboxamide*;   4-((1-acryloylazetidin-3-yl)(methyl)amino)-1H-pyrrolo[2,3-c]pyridine-7-carboxamide;   (R)-4-(1-acryloylpiperidin-3-yl)-1H-indole-7-carboxamide*;   (S)-4-(1-acryloylpiperidin-3-yl)-1H-indole-7-carboxamide*;   (S)-4-(1-acryloylpiperidin-3-yl)-2-methyl-1H-indole-7-carboxamide;   (R)-4-(1-acryloylpiperidin-3-yl)-2-methyl-1H-indole-7-carboxamide;   (R)-4-(4-acryloylmorpholin-2-yl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-indole-7-carboxamide;   (S)-4-(4-acryloylmorpholin-2-yl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-indole-7-carboxamide;   (R)-4-(1-acryloylpyrrolidin-3-yl)-2-(6,7-dihydro-4H-pyrazolo[5,1-c][1,4]oxazin-2-yl)-1H-indole-7-carboxamide;   2-methyl-4-(methyl(1-propioloylazetidin-3-yl)amino)-1H-indole-7-carboxamide;   (S)-4-(1-acryloylpyrrolidin-3-yl)-2-(6,7-dihydro-4H-pyrazolo[5,1-c][1,4]oxazin-2-yl)-1H-indole-7-carboxamide;   (R)-4-(4-acryloyl-1,4-oxazepan-6-yl)-1H-pyrrolo[3,2-c]pyridine-7-carboxamide;   (S)-4-(4-acryloyl-1,4-oxazepan-6-yl)-1H-pyrrolo[3,2-c]pyridine-7-carboxamide;   (R)-4-(1-acryloylpiperidin-3-yl)-1H-pyrrolo[3,2-c]pyridine-7-carboxamide;   (S)-4-(1-acryloylpiperidin-3-yl)-1H-pyrrolo[3,2-c]pyridine-7-carboxamide;   (R)-7-(1-acryloylpiperidin-3-yl)-2-(1-methyl-1H-pyrazol-4-yl)thiazolo[5,4-c]pyridine-4-carboxamide;   (S)-7-(1-acryloylpiperidin-3-yl)-2-(1-methyl-1H-pyrazol-4-yl)thiazolo[5,4-c]pyridine-4-carboxamide;   (S)-4-(4-acryloyl-1,4-oxazepan-6-yl)-1H-indole-7-carboxamide;   4-((3S,5R)-1-acryloyl-5-(hydroxymethyl)piperidin-3-yl)-1H-indole-7-carboxamide;   4-((3S,5S)-1-acryloyl-5-(hydroxymethyl)piperidin-3-yl)-1H-indole-7-carboxamide;   4-((3R,5S)-1-acryloyl-5-(hydroxymethyl)piperidin-3-yl)-1H-indole-7-carboxamide;   4-((3R,5R)-1-acryloyl-5-(hydroxymethyl)piperidin-3-yl)-1H-indole-7-carboxamide;   (R)-4-(1-acryloylpyrrolidin-3-yl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-indole-7-carboxamide;   (S)-4-(1-acryloylpyrrolidin-3-yl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-indole-7-carboxamide;   4-((1R,3R)-3-acrylamidocyclopentyl)-1H-indole-7-carboxamide;   (S)-4-(1-acryloylpiperidin-3-yl)-1H-pyrrolo[2,3-c]pyridine-7-carboxamide;   (R)-4-(1-acryloylpiperidin-3-yl)-1H-pyrrolo[2,3-c]pyridine-7-carboxamide;   (R)-2-methyl-4-(1-propionylpyrrolidin-3-yl)-1H-indole-7-carboxamide;   (S)-2-methyl-4-(1-propionylpyrrolidin-3-yl)-1H-indole-7-carboxamide;   4-((1-acryloylazetidin-3-yl)(methyl)amino)-2-(isochroman-7-yl)-1H-indole-7-carboxamide;   4-((1-acryloylazetidin-3-yl)(methyl)amino)-2-(6,7-dihydro-4H-pyrazolo[5,1-c][1,4]oxazin-2-yl)-1H-indole-7-carboxamide;   4-((1-acryloylazetidin-3-yl)(methyl)amino)-2-(4,4-difluorocyclohex-1-en-1-yl)-1H-indole-7-carboxamide;   4-((1-acryloylazetidin-3-yl)(methyl)amino)-2-(4-(methylsulfonyl)cyclohex-1-en-1-yl)-1H-indole-7-carboxamide;   4-((1-acryloylazetidin-3-yl)(methyl)amino)-2-(6-morpholinopyridin-3-yl)-1H-indole-7-carboxamide;   4-((1-acryloylazetidin-3-yl)(methyl)amino)-2-(7,8-dihydro-5H-pyrano[4,3-b]pyridin-3-yl)-1H-indole-7-carboxamide;   4-((1-acryloylazetidin-3-yl)(methyl)amino)-2-(chroman-7-yl)-1H-indole-7-carboxamide;   4-((1-acryloylazetidin-3-yl)(methyl)amino)-2-(5-(morpholinomethyl)pyridin-2-yl)-1H-indole-7-carboxamide;   4-((1-acryloylazetidin-3-yl)(methyl)amino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-indole-7-carboxamide;   4-((1-acryloylazetidin-3-yl)(methyl)amino)-2-(3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)-1H-indole-7-carboxamide;   4-((1-acryloylazetidin-3-yl)(methyl)amino)-2-(1-methyl-1H-pyrazol-5-yl)-1H-indole-7-carboxamide;   4-((1-acryloylazetidin-3-yl)(methyl)amino)-2-(2-ethyl-1,2,3,4-tetrahydroisoquinolin-6-yl)-1H-indole-7-carboxamide;   4-((1-acryloylazetidin-3-yl)(methyl)amino)-2-(1,3-dimethyl-1H-pyrazol-4-yl)-1H-indole-7-carboxamide;   4-((1-acryloylazetidin-3-yl)(methyl)amino)-2-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-1H-indole-7-carboxamide;   4-((1-acryloylazetidin-3-yl)(methyl)amino)-2-(1-propylpiperidin-4-yl)-1H-indole-7-carboxamide;   4-((1-acryloylazetidin-3-yl)(methyl)amino)-2-(tetrahydrofuran-3-yl)-1H-indole-7-carboxamide;   4-((1-acryloylazetidin-3-yl)(methyl)amino)-2-(3-hydroxyoxetan-3-yl)-1H-indole-7-carboxamide;   4-((1-acryloylazetidin-3-yl)(methyl)amino)-2-methyl-1H-indole-7-carboxamide;   (R)-4-(4-acryloyl-1,4-oxazepan-6-yl)-1H-indole-7-carboxamide;   (S)-4-(1-acryloylpyrrolidin-3-yl)-2-methyl-1H-indole-7-carboxamide*;   (R)-4-(1-acryloylpyrrolidin-3-yl)-2-methyl-1H-indole-7-carboxamide*;   4-((1R,5S)-6-acryloyl-3,6-diazabicyclo[3.2.0]heptan-3-yl)-1H-indole-7-carboxamide;   4-((1S,5R)-6-acryloyl-3,6-diazabicyclo[3.2.0]heptan-3-yl)-1H-indole-7-carboxamide;   (R)-4-(1-(1-acryloylazetidin-3-yl)ethyl)-1H-pyrrolo[3,2-c]pyridine-7-carboxamide;   (S)-4-(1-(1-acryloylazetidin-3-yl)ethyl)-1H-pyrrolo[3,2-c]pyridine-7-carboxamide;   4-((1-acryloylazetidin-3-yl)amino)-1H-pyrrolo[2,3-c]pyridine-7-carboxamide;   4-((1-acryloyl-3-methylazetidin-3-yl)(methyl)amino)-1H-indole-7-carboxamide;   4-((1-cyanoazetidin-3-yl)(methyl)amino)-2-methyl-1H-indole-7-carboxamide;   4-(2-chloro-6-fluorobenzyl)-2-p-tolyl-1H-indole-7-carboxamide;   (S)-4-((1-acryloylazetidin-3-yl)(methyl)amino)-2-(tetrahydrofuran-3-yl)-1H-indole-7-carboxamide;   (R)-4-((1-acryloylazetidin-3-yl)(methyl)amino)-2-(tetrahydrofuran-3-yl)-1H-indole-7-carboxamide;   (S)-4-(4-acryloyl-1,4-oxazepan-6-yl)-1H-pyrrolo[2,3-c]pyridine-7-carboxamide;   (R)-4-(4-acryloyl-1,4-oxazepan-6-yl)-1H-pyrrolo[2, 3-c]pyridine-7-carboxamide;   (S)-4-(1-acryloylpiperidin-3-yl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-indole-7-carboxamide; or   (R)-4-(1-acryloylpiperidin-3-yl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-indole-7-carboxamide.   
     
     
         21 - 25 . (canceled)