Qsox1 as an anti-neoplastic drug target

Abstract

The present invention provides methods for tumor treatment by administering an inhibitor of quiescin sulfhydryl oxidase 1 (QSOX1), compositions comprising such inhibitors, and methods for identifying such inhibitors.

1 . A method for tumor treatment, comprising administering to a subject having a tumor an amount effective of an anti quiescin sulfhydryl oxidase 1 (QSOX1) antibody, or a pharmaceutically acceptable salt thereof, to treat the tumor. 
     
     
         2 . (canceled) 
     
     
         3 . The method of  claim 1 , wherein the tumor is a tumor that over-expresses QSOX1 compared to control. 
     
     
         4 . The method of  claim 1 , wherein the tumor is a pancreatic tumor. 
     
     
         5 . The method of  claim 4 , wherein the pancreatic tumor comprises a pancreatic adenocarcinoma. 
     
     
         6 . The method of  claim 1 , wherein the tumor is a breast tumor. 
     
     
         7 . The method of  claim 6 , wherein the tumor is an estrogen receptor positive (ER+) breast tumor. 
     
     
         8 . The method of  claim 6 , wherein the breast tumor is a Luminal B breast tumor. 
     
     
         9 . (canceled) 
     
     
         10 . The method of  claim 1 , wherein the method limits tumor metastasis. 
     
     
         11 . A method inhibiting tumor metastasis, comprising administering to a subject having a tumor an amount effective of an anti quiescin sulfhydryl oxidase 1 (QSOX1) antibody, or a pharmaceutically acceptable salt thereof, to inhibit metastasis of the tumor. 
     
     
         12 . (canceled) 
     
     
         13 . The method of  claim 11 , wherein the tumor is a breast tumor. 
     
     
         14 . The method of  claim 11 , wherein the tumor is a cytokeratin 5/6 negative breast tumor, 
       or a Luminal B breast tumor. 
     
     
         15 . The method of  claim 11 , wherein the tumor is a pancreatic tumor. 
     
     
         16 . (canceled)