Macrocyclic picolinamides compounds with fungicidal activity

Abstract

The invention relates to compounds of macrocyclic picolinamides of Formula I suitable to control or prevent growth of fungi.

What is claimed is: 
     
         1 . A compound of Formula I 
       
         
           
           
               
               
           
         
         wherein: 
         X is C(O)R 3 , or CH 2 OR 3 ; 
         Y is H, C(O)R 3 , 
         R 1  is chosen from H, alkyl, alkenyl, aryl, —Si(R 5 ) 3  or —C(O)R 6 , each optionally substituted with 0, 1 or multiple R 6 ; 
         R 2  is chosen from CH 2 R 8 , aryl, alkyl, or alkenyl, each optionally substituted with 0, 1, or multiple R 6 , 
         R 3  is chosen from alkyl, alkoxy, benzyl, or benzyloxy, each optionally substituted with 0, 1, or multiple R 5 ; 
         R 5  is chosen from alkyl, halo, or alkoxy; 
         R 6  is chosen from alkyl, alkenyl, halo, haloalkyl, alkoxy, aryl, heteroaryl, heterocyclyl, thioalkyl, or —C(O)R 5 ; and 
         R 8  is chosen from H, alkyl, alkenyl, aryl, thioalkyl, or heteroaryl, each optionally substituted with 0, 1, or multiple R 6 . 
       
     
     
         2 . The compound according to  claim 1 , wherein X and Y are independently chosen from H, C(O)R 3 , or CH 2 OR 3 . 
     
     
         3 . The compound according to  claim 2 , wherein R 1  is chosen from H, alkyl, alkenyl, phenyl, —Si(R 5 ) 3 , or —C(O)R 6 , each optionally substituted with 0, 1 or multiple R 6 . 
     
     
         4 . The compound according to  claim 3 , wherein R 2  is chosen from CH 2 R 8 , phenyl, alkyl, or alkenyl, each optionally substituted with 0, 1, or multiple R 6 . 
     
     
         5 . The compound according to  claim 4 , wherein R 8  is chosen from H, alkyl, alkenyl, phenyl, or heteroaryl, each optionally substituted with 0, 1, or multiple R 6 . 
     
     
         6 . A formulation for the control of a fungal pathogen, comprising:
 at least one of the compounds of  claim 1 ; and   a phytologically acceptable carrier material.   
     
     
         7 . The formulation according to  claim 6 , wherein the formulation is suitable for treating plants. 
     
     
         8 . A formulation for the control of a fungal pathogen, comprising:
 at least one of the compounds of  claim 1 ; and   at least one agriculturally active ingredient selected from the group consisting of: fungicides, insecticides, nematocides, miticides, arthropodicides, bactericides and combinations thereof.   
     
     
         9 . The formulation according to  claim 8 , wherein the formulation is suitable for treating plants. 
     
     
         10 . A formulation for the control of a fungal pathogen, comprising:
 the formulation of  claim 6 ; and   at least one agriculturally active ingredient selected from the group consisting of: fungicides, insecticides, nematocides, miticides, arthropodicides, bactericides and combinations thereof.   
     
     
         11 . The formulation according to  claim 10 , wherein the formulation is suitable for treating plants.