Abuse deterrent immediate release biphasic matrix solid dosage form

Abstract

An abuse deterrent immediate release biphasic matrix solid dosage form that releases the drug at a desired rate for quick onset of action when a single unit or prescribed units of the dosage form are orally administered but exhibits a reduced rate of release when more than the prescribed number of units, are administered.

What is claimed is: 
     
         1 . An abuse deterrent immediate release biphasic matrix solid dosage form comprising:
 an intragranular phase comprising a mixture of a drug susceptible to abuse and a reverse enteric polymer;   an extragranular phase;   and an alkalizer,   wherein the intragranular phase further comprises a first part of the alkalizer and the extragranular phase comprises a second part of the alkalizer.   
     
     
         2 . The abuse deterrent immediate release biphasic matrix solid dosage form according to  claim 1   wherein the drug susceptible to abuse and the reverse enteric polymer are melt extruded to form a solid dispersion characterized by the absence of X-ray diffraction peaks characteristic of the crystalline drug.   
     
     
         3 . The abuse deterrent immediate release biphasic matrix solid dosage form according to  claim 1 , further comprising an alcohol dose dumping resistance polymer located only in the intragranular phase. 
     
     
         4 . The abuse deterrent immediate release biphasic matrix solid dosage form according to  claim 1 , further comprising an alcohol dose dumping resistance polymer located in both the intragranular phase and extragranular phase. 
     
     
         5 . The abuse deterrent immediate release biphasic matrix solid dosage form according to  claim 1 , further comprising an alcohol dose dumping resistance polymer that covers the intragranular phase. 
     
     
         6 . The abuse deterrent immediate release biphasic matrix solid dosage form according to  claim 5 , wherein the alcohol dose dumping resistance polymer is also present in the intragranular phase. 
     
     
         7 . The abuse deterrent immediate release biphasic matrix solid dosage form according to  claim 6 , wherein the alcohol dose dumping resistance polymer is also present in the extragranular phase.