Pyrazolo[1,5-a]pyrimidines for antiviral treatment

Abstract

The invention provides compounds of Formula I or Formula II: or a pharmaceutically acceptable salt or ester, thereof, as described herein. The compounds and compositions thereof are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections.

1 - 38 . (canceled) 
     
     
         39 . A compound of Formula VIIc: 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt thereof; 
         wherein:
 R 1  is H; 
 R 7  is C 1-8  alkyl; 
 R 8  is pyrrolidinyl or azetidinyl wherein pyrrolidinyl or azetidinyl is optionally substituted with one or more hydroxy, NH 2 , or —CN; and 
 Ar is