Sugar compositions for tableting by direct compression

Abstract

The present invention relates to directly compressible compositions comprising more than 30% by weight of allulose, and to tablets obtainable thereof.

1 . Granules of allulose which are compressible in the sole presence of a lubricant, to form a tablet having a diameter of 13 mm, a thickness of 6 mm, an apparent density of 1.35 g/ml ±0.02 g/ml, a cylindrical shape with convex faces with a radius of curvature of 13 mm, whose hardness is greater than 50 N. 
     
     
         2 . A method of providing a direct compression excipient in a directly compressible composition by providing an effective amount of the granules of allulose of  claim 1 . 
     
     
         3 . The method of  claim 2 , wherein the granules of allulose are further used as a sweetener, and/or a low-calorie sweetener, and/or as a health ingredient having physiological functions such as blood glucose suppressive effect, and/or reactive oxygen species scavenging activity, and/or neuroprotective effect. 
     
     
         4 . A directly compressible composition, comprising the granules of allulose of  claim 1 . 
     
     
         5 . The directly compressible composition of  claim 4 , wherein said granules of allulose represent at least 30% of the directly compressible composition, said percentage being expressed in dry weight, with respect to the total dry weight of said directly compressible composition. 
     
     
         6 . The directly compressible composition according to  claim 4 , comprising no more than 60% of direct compression excipients other than said granules of allulose, said percentage being expressed in dry weight, with respect to the total dry weight of said directly compressible composition. 
     
     
         7 . A method for the manufacture of granules of allulose such as defined in  claim 1 , comprising:
 a step (a) of preparing a granulation liquid comprising allulose;   a step (b) of granulating powdery allulose, by applying the granulation liquid obtained in step (a) onto moving powdery allulose;   a step (c), simultaneous with step (b), of drying the granules obtained in step (b);   a step (c′) of maturation of the granules obtained in step (c);   a step (d) of recovering the granules obtained in step (c) or (c′).   
     
     
         8 . A method for the manufacture of a tablet, comprising the steps of: providing a directly compressible composition according to  claim 4 ; followed by directly compressing said composition to form the tablet. 
     
     
         9 . A tablet composed of a directly compressible composition as defined in  claim 4 . 
     
     
         10 . The granules of allulose of  claim 1 , wherein the tablet has a hardness greater than 60 N. 
     
     
         11 . The granules of allulose of  claim 1 , wherein the tablet has a hardness greater than 70 N. 
     
     
         12 . The granules of allulose of  claim 1 , wherein the tablet has a hardness greater than 80 N. 
     
     
         13 . The granules of allulose of  claim 1 , wherein the tablet has a hardness greater than 90 N. 
     
     
         14 . The granules of allulose of  claim 1 , wherein the tablet has a hardness greater than 100 N. 
     
     
         15 . The granules of allulose of  claim 1 , wherein the tablet has a hardness greater than 110 N. 
     
     
         16 . The directly compressible composition of  claim 4 , wherein said granules of allulose represent at least 40% of the directly compressible composition, said percentage being expressed in dry weight, with respect to the total dry weight of said directly compressible composition. 
     
     
         17 . The directly compressible composition of  claim 4 , wherein said granules of allulose represent at least 50% of the directly compressible composition, said percentage being expressed in dry weight, with respect to the total dry weight of said directly compressible composition. 
     
     
         18 . The directly compressible composition of  claim 4 , wherein said granules of allulose represent at least 60% of the directly compressible composition, said percentage being expressed in dry weight, with respect to the total dry weight of said directly compressible composition. 
     
     
         19 . The directly compressible composition of  claim 4 , wherein said granules of allulose represent at least 70% of the directly compressible composition, said percentage being expressed in dry weight, with respect to the total dry weight of said directly compressible composition. 
     
     
         20 . The directly compressible composition of  claim 4 , wherein said granules of allulose represent at least 80% of the directly compressible composition, said percentage being expressed in dry weight, with respect to the total dry weight of said directly compressible composition.