Nutritional compositions containing phosphatidylserine powder

Abstract

Phosphatidylserine powder compositions of the present invention were found to provide more homogeneous dispersion and demonstrate reduced sedimentation, compared to conventional phosphatidylserine powders, when mixed without processing by high pressure homogenization in water or other liquids. The composition of the present invention comprises phosphatidylserine and at least 80% (w/w) of the composition has a particle size of 500 microns or less. Nutritional, nutraceutical, or pharmaceutical compositions including the phosphatidylserine powder compositions of the present invention are also provided. Process for preparing phosphatidylserine powder compositions according to the present invention is also provided and includes sieving.

The claims are: 
     
         1 . A phosphatidylserine powder composition comprising a phosphatidylserine, wherein at least 80% (w/w) of the phosphatidylserine powder composition has a particle size of 500 microns or less. 
     
     
         2 . A phosphatidylserine powder composition comprising a phosphatidylserine, wherein less than 20% (w/w) of the phosphatidylserine powder composition has a particle size of above 500 microns. 
     
     
         3 . The phosphatidylserine powder composition of  claim 1 , wherein at least 97% (w/w) of the phosphatidylserine powder composition has a particle size of 250 microns or less. 
     
     
         4 . The phosphatidylserine powder composition of  claim 1 , wherein the phosphatidylserine is prepared using a monophasic reaction. 
     
     
         5 . The phosphatidylserine powder composition of  claim 4 , wherein the phosphatidylserine is purified using an organic solvent. 
     
     
         6 . The phosphatidylserine powder composition of  claim 5 , wherein the organic solvent is an alcohol solvent. 
     
     
         7 . The phosphatidylserine powder composition of  claim 1 , wherein the phosphatidylserine is prepared using a bi-phasic reaction. 
     
     
         8 . The phosphatidylserine powder composition of  claim 1 , wherein the powder composition when mixed in water without processing by high pressure homogenization, disperses more homogeneously and demonstrates reduced sedimentation compared to a PS preparation in which more than 20% (w/w) of the PS preparation has a particle size of above 500 microns. 
     
     
         9 . The phosphatidylserine powder composition of  claim 1 , wherein the powder composition is mixed with a powder nutritional, nutraceutical, or pharmaceutical composition to form a mixture that when mixed with water without processing by high pressure homogenization, the mixture disperses more homogeneously and reduces sedimentation compared to a mixture of the powder nutritional, nutraceutical, or pharmaceutical composition and a PS preparation in which more than 20% (w/w) of the PS preparation has a particle size of above 500 microns. 
     
     
         10 . The phosphatidylserine powder composition of  claim 1 , wherein the powder composition when mixed without processing by high pressure homogenization with a liquid nutritional, nutraceutical, or pharmaceutical composition disperses more homogeneously and demonstrates reduced sedimentation compared to a PS preparation in which more than 20% (w/w) of the PS preparation has a particle size of above 500 microns. 
     
     
         11 . A nutritional, nutraceutical, or pharmaceutical composition comprising the phosphatidylserine powder composition of  claim 1 . 
     
     
         12 . The composition of  claim 11 , wherein the nutraceutical or pharmaceutical composition is a pill, tablet, pellets, dragees, capsule, softgel, or syrup. 
     
     
         13 . The composition of  claim 11 , wherein the nutritional or nutraceutical composition is a baby formula, adult formula, or a medical nutrition product. 
     
     
         14 . The composition of  claim 11 , wherein the nutritional, nutraceutical, or pharmaceutical composition is a candy, gummy, or confectionary. 
     
     
         15 . The composition of  claim 14 , wherein the gummy maintains a uniform appearance and elastic stability during storage. 
     
     
         16 . The composition as in  claim 11 , wherein the bulk density of the phosphatidylserine powder composition is 0.2 to 0.7 g/ml. 
     
     
         17 . The composition as in  claim 11 , wherein the dosage unit of the phosphatidylserine powder composition is 10 mg to 1000 mg. 
     
     
         18 . The composition of  claim 11 , wherein the nutritional, nutraceutical, or pharmaceutical composition is a liquid. 
     
     
         19 . The composition of  claim 11 , wherein the nutritional, nutraceutical, or pharmaceutical composition is a powder. 
     
     
         20 . The composition as in  claim 11 , wherein the nutritional, nutraceutical, or pharmaceutical composition contains at least one protein and at least one carbohydrate. 
     
     
         21 . The composition of  claim 11 , wherein the phosphatidylserine powder is at least 0.05% (w/w) of the nutritional, nutraceutical, or pharmaceutical composition. 
     
     
         22 . The composition of  claim 11 , wherein the phosphatidylserine is prepared using a monophasic reaction. 
     
     
         23 . The composition of  claim 22 , wherein the phosphatidylserine is purified using an organic solvent. 
     
     
         24 . The composition of  claim 23 , wherein the organic solvent is an alcohol solvent. 
     
     
         25 . The composition of  claim 11 , wherein the phosphatidylserine is prepared using a bi-phasic reaction. 
     
     
         26 . A process for preparing a phosphatidylserine powder preparation comprising sieving a phosphatidylserine powder, wherein the resulting phosphatidylserine powder preparation is the phosphatidylserine powder composition of  claim 1 . 
     
     
         27 . The process for preparing a phosphatidylserine powder preparation of  claim 26 , wherein the phosphatidylserine is produced using a monophasic reaction. 
     
     
         28 . The process for preparing a phosphatidylserine powder preparation of  claim 27 , wherein the phosphatidylserine is purified using an organic solvent. 
     
     
         29 . The process for preparing a phosphatidylserine powder preparation of  claim 26 , wherein the phosphatidylserine is produced using a bi-phasic reaction. 
     
     
         30 . The process for preparing a phosphatidylserine powder preparation of  claim 26 , further comprising a dry milling step wherein the phosphatidylserine is dried then milled to obtain a dry milled powder. 
     
     
         31 . The process for preparing a phosphatidylserine powder preparation of  claim 30 , wherein the phosphatidylserine is milled together with silicon dioxide. 
     
     
         32 . The process for preparing a phosphatidylserine powder preparation of  claim 30 , wherein the dry milled powder is a free flowing powder. 
     
     
         33 . The process for preparing a phosphatidylserine powder preparation of  claim 26 , further comprising a purification step using an alcohol solvent. 
     
     
         34 . The process for preparing a phosphatidylserine powder preparation of  claim 33 , wherein the alcohol solvent is a C1-C6 alcohol. 
     
     
         35 . The process for preparing a phosphatidylserine powder preparation of  claim 33 , wherein the alcohol solvent is a C2-C3 alcohol.