Compounds and uses

Abstract

There is provided compounds of formula I, wherein E 1 , E 2 , E 3 , E 4 , L 1 , Y 1 , Y 2 , Y 3 , R a and z have meanings provided in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of leukotriene C 4 synthase is desired and/or required, and particularly in the treatment of respiratory diseases and inflammation.

1 - 19 . (canceled) 
     
     
         20 . A method of treating a disease in which inhibition of leukotriene C 4  synthase is desired and/or required, wherein the method comprises administering to a patient in need thereof, a therapeutically effective amount of a compound of formula I: 
       
         
           
           
               
               
           
         
         or a pharmaceutically-acceptable salt thereof. 
       
     
     
         21 . The method of  claim 20 , comprising administering a therapeutically effective amount of a compound of formula I: 
       
         
           
           
               
               
           
         
       
     
     
         22 . A method of treating a disease in which inhibition or decrease of the formation of one or more of LTC 4 , LTD 4  and LTE 4  and/or EXC 4 , EXD 4  and EXE 4  is desired and/or required, wherein the method comprises administering to a patient in need thereof, a therapeutically effective amount of a compound of formula I 
       
         
           
           
               
               
           
         
         or a pharmaceutically-acceptable salt thereof. 
       
     
     
         23 . The method of  claim 22 , comprising administering a therapeutically effective amount of a compound of formula I: 
       
         
           
           
               
               
           
         
       
     
     
         24 . A method of treating a respiratory disease/disorder, inflammation and/or disease/disorder having an inflammatory component to a patient in need thereof, wherein the method comprises administering a therapeutically effective amount of a compound of formula I 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof. 
     
     
         25 . The method of  claim 24 , comprising administering a therapeutically effective amount of a compound of formula I: 
       
         
           
           
               
               
           
         
       
     
     
         26 . The method of  claim 24  or  claim 25 , wherein the respiratory disease/disorder, inflammation and/or disease/disorder having an inflammatory component is asthma.