US2017217967A1PendingUtilityA1

Polymorph of syk inhibitors

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Assignee: GILEAD CONNECTICUT INCPriority: Jul 30, 2013Filed: Apr 11, 2017Published: Aug 3, 2017
Est. expiryJul 30, 2033(~7 yrs left)· nominal 20-yr term from priority
Inventors:Tim G. ElfordPeter FungMichael Laird HurreyDimitrios StefanidisDragos Vizitiu
A61P 35/02A61P 35/00A61P 37/06A61P 37/00A61P 29/00A61P 25/02A61P 25/00A61P 11/06A61P 19/02C07D 487/04C07C 309/04
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Claims

Abstract

Polymorphs of a bis-mesylate salt of a compound of Formula I: or a hydrate thereof, are provided. The bis-mesylate salt may also be depicted as a compound of Formula IA: Provided herein are also compositions thereof, methods for their preparation and methods for such polymorphs.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
         1 . A bis-mesylate salt of a compound of Formula I: 
       
         
           
           
               
               
           
         
         or a hydrate thereof. 
       
     
     
         2 . The bis-mesylate salt of  claim 1 , wherein the bis-mesylate salt, or a hydrate thereof, is:
 a compound of Formula IB:   
       
         
           
           
               
               
           
         
       
       or
 a compound of Formula IC: 
 
       
         
           
           
               
               
           
         
       
       or
 a compound of Formula ID: 
 
       
         
           
           
               
               
           
         
         
           wherein y is at least 0.5. 
         
       
     
     
         3 . The bis-mesylate salt of  claim 1 , wherein the bis-mesylate salt, or a hydrate thereof, is crystalline.

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