Composition for cosmetic use suitable to produce a pigmentation effect on hair

Abstract

The invention concerns the use of compounds with formula (I) R—N1-spermidine, or 1,4-butandiamin,N-(3-amino propyl)-N1-R, (I) H 2 N—(CH 2 ) 3 —N 1 (R)—(CH 2 ) 4 —NH 2 either as such or in the form of a pharmaceutically acceptable derivative, such as an active ingredient in a cosmetic composition designed to promote hair pigmentation, particularly the pigmentation of the shaft, and a composition suitable to achieve said pigmentation effect and containing said active ingredient, either as such or in the form of a pharmaceutically acceptable derivative such as a salt, for topical administration.

1 - 18 . (canceled) 
     
     
         19 . Method for producing a melanogenetic action in the hair and to promote its pigmentation and pigmentation of the stem, comprising the step of administering to a subject in need thereof an effective dose of a compound of formula (I) R—N 1 -spermidine, or 1,4-butandiamin,N-(3-amino propyl)-N 1 —R,
   H 2 N—(CH 2 ) 3 —N 1 (R)—(CH 2 ) 4 —NH 2    (I)
 
 wherein R is a substituent that is bound to the secondary amine group of spermidine, chosen from saturated or unsaturated, linear or branched alkyl groups formed from 1 to 6 atoms of carbon, wherein one or more carbon atoms are optionally replaced by fluorine, namely methyl, ethyl, trifluoromethyl, trifluoroethyl, propyl, isopropyl, butyl, isobutyl, pentyl, hexyl, ethylene, vinyl, propylene, butylene; 
 aryl or aryl-alkyl groups, such as phenyl, naphthyl, benzyl, tolyl, wherein one or more carbon atoms are optionally replaced by fluorine, and wherein said aryl-alkyl groups include saturated or unsaturated, linear or branched alkyl groups formed by 1 to 6 atoms of carbon, wherein one or more carbon atoms are optionally replaced by fluorine, namely methyl, ethyl, trifluoromethyl, trifluoroethyl, propyl, isopropyl, butyl, isobutyl, pentyl, hexyl, ethylene, vinyl, propylene, butylene; 
 saturated or unsaturated cycloalkyl groups formed by 3 to 8 atoms of carbon that are optionally replaced by saturated or unsaturated, linear or branched alkyl groups formed by 1 to 6 atoms of carbon, wherein one or more carbon atoms are optionally replaced by fluorine, namely methyl, ethyl, trifluoromethyl, trifluoroethyl, propyl, isopropyl, butyl, isobutyl, pentyl, hexyl, ethylene, vinyl, propylene, butylene; or their pharmaceutically acceptable salt. 
 
     
     
         20 . Method according to  claim 19 , wherein said formula (I) is applied topically to the scalp. 
     
     
         21 . Method according to  claim 19 , wherein said compound of formula (I) is N 1 -methyl-spermidine of formula:
   H 2 N—(CH 2 ) 3 —N 1 (CH 3 )—(CH 2 ) 4 —NH 2    (II)
   
     
     
         22 . Method according to  claim 19 , wherein said compound of formula (I) is N 1 -cyclohexyl-spermidine with formula:
   H 2 N—(CH 2 ) 3 —N 1 (C 6 H 11 )—(CH 2 ) 4 —NH 2    (III)
   
     
     
         23 . Method according to  claim 19 , wherein said compound of formula (I) is N 1 -ethyl-spermidine of formula:
   H 2 N—(CH 2 ) 3 —N 1 (C 2 H 5 )—(CH 2 ) 4 —NH 2    (IV)
   
     
     
         24 . Method according to  claim 19 , wherein said compound of formula (I) is N 1 -propyl-spermidine of formula:
   H 2 N—(CH 2 ) 3 —N 1 (C 3 H 7 )—(CH 2 ) 4 —NH 2    (V)
   
     
     
         25 . Method according to  claim 19 , wherein said pharmaceutically acceptable salt of said compound with formula (I) is a salt with maleic acid. 
     
     
         26 . Method according to  claim 19 , wherein said pharmaceutically acceptable salt of said compound with formula (I) is a salt with hydrochloric acid.