Ionizing-radiation-responsive compositions, methods, and systems

Abstract

A method, composition and system respond to ionizing radiation to adjust biological activity. In some approaches the ionizing radiation is X-ray or extreme ultraviolet radiation that produces luminescent responses that induce biologically active responses.

What is claimed is: 
     
         1 - 142 . (canceled) 
     
     
         143 . A method, comprising:
 delivering to at least one region an ionizing-radiation-responsive composition, the ionizing-radiation-responsive composition including:
 a luminescent material, the luminescent material being responsive to ionizing radiation in at least one ionizing radiation energy band to produce optical energy in at least one optical wavelength band; 
 a photosensitive biologically active material, the photosensitive biologically active material being responsive to optical energy in the at least one optical wavelength band; and 
 a matrix material disposed to at least partially sustain proximity of the luminescent material and the photosensitive biologically active material; and 
   irradiating at least a portion of the at least one region with ionizing radiation in the at least one ionizing radiation energy band.   
     
     
         144 . A method, comprising:
 delivering to at least one region an ionizing-radiation-responsive composition, the ionizing-radiation-responsive composition including:
 a luminescent material, the luminescent material being responsive to ionizing radiation in at least one ionizing radiation energy band to produce optical energy in at least one optical wavelength band; 
 a photosensitive biologically active material, the photosensitive biologically active material being responsive to optical energy in the at least one optical wavelength band; and 
 an optically-inhibiting material disposed to at least partially block coupling of optical energy in the at least one optical wavelength band to the photosensitive biologically active material; and 
   irradiating at least a portion of the at least one region with ionizing radiation in the at least one ionizing radiation energy band.   
     
     
         145 . A method, comprising:
 delivering to at least one region an ionizing-radiation-responsive composition, the ionizing-radiation-responsive composition including:
 a luminescent material, the luminescent material being responsive to ionizing radiation in at least one ionizing radiation energy band to produce optical energy in at least one optical wavelength band; 
 a photosensitive biologically active material, the photosensitive biologically active material being responsive to optical energy in the at least one optical wavelength band; and 
 a coating material of a type selected to adjust at least one of the solubility, durability, suspension stability, bioactivity, biocompatibility, and non-toxicity of the ionizing-radiation-responsive composition; and 
   irradiating at least a portion of the at least one region with ionizing radiation in the at least one ionizing radiation energy band.   
     
     
         146 - 214 . (canceled)