Sodium tetradecyl sulfate formulations for treatment of adipose tissue

Abstract

Contained herein are compositions, formulations, methods, and kits for treating regional fat deposits and fat-related conditions. Certain methods comprise administering tetradecyl sulfate, tetradecyl sulfate-like compounds, and pharmaceutically or cosmetically acceptable salts, solvates, prodrugs, or esters thereof and a liquid carrier.

1 .- 109 . (canceled) 
     
     
         110 . A formulation for subcutaneous delivery, comprising:
 a. a therapeutically or cosmetically effective amount of tetradecyl sulfate in an amount that is up to about 10% w/v, or a pharmaceutically or cosmetically acceptable salt, solvate, prodrug, or ester thereof; and   b. a liquid carrier;   
       provided that the formulation is formulated for subcutaneous delivery. 
     
     
         111 . The formulation of  claim 110 , wherein the tetradecyl sulfate is sodium tetradecyl sulfate. 
     
     
         112 . The formulation of  claim 110 , further comprising propylene glycol. 
     
     
         113 . The formulation of  claim 110 , wherein the tetradecyl sulfate is micronized. 
     
     
         114 . The formulation of  claim 110 , further comprising a microparticulate and/or nanoparticulate carrier. 
     
     
         115 . The formulation of  claim 110 , wherein the formulation is stable for a period of at least 6 months at a temperature of about 0° C. to about 50° C. 
     
     
         116 . The formulation of  claim 110 , further comprising an alcohol having 3 to 7 carbon atoms is present in an amount from about 0.5% w/v to about 10% w/v. 
     
     
         117 . The formulation of  claim 110 , further comprising an alcohol having 3 to 7 carbon atoms is present in an amount of approximately 2% w/v. 
     
     
         118 . The formulation of  claim 110 , wherein the tetradecyl sulfate is present in an amount less than 5% w/v. 
     
     
         119 . The formulation of  claim 110 , wherein the tetradecyl sulfate is present in an amount from about 0.5% to 3% w/v. 
     
     
         120 . The formulation of  claim 110 , wherein the tetradecyl sulfate is present in an amount of 0.5%, 1%, or 3%. 
     
     
         121 . The formulation of  claim 110 , wherein the formulation has a pH of about 6 to 10. 
     
     
         122 . The formulation of  claim 110 , wherein the formulation has a pH of about 7 to 8. 
     
     
         123 . The formulation of  claim 110 , wherein the injection volume is less than about 2 ml. 
     
     
         124 . The formulation of  claim 110 , wherein the injection volume is less than about 0.5 ml. 
     
     
         125 . A kit for treating adipose tissue comprising:
 a. a formulation comprising:
 i. a therapeutically or cosmetically effective amount of tetradecyl sulfate in an amount that is up to about 10% w/v, or a pharmaceutically or cosmetically acceptable salt, solvate, prodrug, or ester thereof; and, 
 ii. a liquid carrier; and, 
   b. instructions for use;   
       provided that the formulation is formulated for subcutaneous delivery. 
     
     
         126 . The kit of  claim 125 , wherein the tetradecyl sulfate is sodium tetradecyl sulfate. 
     
     
         127 . The kit of  claim 125 , wherein the formulation further comprises propylene glycol. 
     
     
         128 . The kit of  claim 125 , wherein the tetradecyl sulfate is present in an amount from about 0.5% to 3% w/v. 
     
     
         129 . The kit of  claim 125 , wherein the tetradecyl sulfate is present in an amount of 0.5%, 1%, or 3%.