Pharmaceutical and food compositions for inducing satiation and prolonging satiety in subjects in need thereof

Abstract

The present invention relates to pharmaceutical and food compositions for inducing satiation and prolonging satiety in subjects in need thereof. In particular, the present invention relates to a method of inducing satiation in a subject in need thereof comprising administering to the subject an effective amount of a ClpB protein or an effective amount of a bacterium that expresses the ClpB protein.

1 - 45 . (canceled) 
     
     
         46 . A method of stimulating weight loss in a subject in need thereof comprising administering to the subject an effective amount of a ClpB protein or an effective amount of a bacterium that expresses the ClpB protein. 
     
     
         47 . The method of  claim 46 , wherein the subject the subject is not obese. 
     
     
         48 . The method of  claim 46 , wherein the subject is obese. 
     
     
         49 . The method of  claim 46 , wherein the ClpB protein comprises an amino acid sequence having at least 80% of identity with SEQ ID NO:1. 
     
     
         50 . The method of  claim 46 , wherein the ClpB protein or the bacterium that expresses the ClpB protein is administered to the subject in the form of a pharmaceutical composition. 
     
     
         51 . The method of  claim 46 , wherein the ClpB protein or bacterium that expresses the ClpB protein is administered to the subject in the form of a food composition. 
     
     
         52 . The method of  claim 46 , wherein the bacterium that expresses the ClpB protein is a probiotic bacterial strain. 
     
     
         53 . The method of  claim 52 , wherein the probiotic bacterial strain is a naturally occurring bacterial strain or is a genetically engineered bacterial strain. 
     
     
         54 . The method of  claim 52 , wherein the probiotic bacterial strain is a member of the family of Enterobacteriaceae. 
     
     
         55 . The method of  claim 46 , wherein the bacterium that expresses the ClpB protein is a probiotic bacterial strain that is administered in the form of a food composition. 
     
     
         56 . The method of  claim 55 , wherein the food composition that comprises the probiotic bacterial strain is selected from complete food compositions, food supplements, nutraceutical compositions, and the like. 
     
     
         57 . The method of  claim 55 , wherein the food composition is a fermented dairy product. 
     
     
         58 . The method of  claim 55 , wherein the food composition if a functional food. 
     
     
         59 . The method of  claim 55 , wherein the food composition is a drink. 
     
     
         60 . The method of  claim 55 , wherein the food composition is a meal replacement product. 
     
     
         61 . The method of claim  10 , wherein the food composition comprises an amount of dietary fibers. 
     
     
         62 . The method of claim  10 , wherein the food composition comprises at least one prebiotic. 
     
     
         63 . The method of  claim 46 , wherein the ClpB protein or the bacterium that expresses the ClpB protein is administered simultaneously or sequentially with one meal of the subject. 
     
     
         64 . The method of  claim 46 , wherein the method induces satiation and/or prolongs satiety in the subject. 
     
     
         65 . The method of  claim 46 , wherein the method reduces the meal size and/or the food intake of the subject.