Antifungal agents and uses thereof

Abstract

The invention features echinocandin class compounds. The compounds can be useful for the treatment of fungal infections.

What is claimed is: 
     
         1 . A compound having the formula: 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof. 
     
     
         2 . The compound of  claim 1 , wherein said compound is an acetate salt. 
     
     
         3 . The compound of  claim 1 , wherein said compound is a chloride salt. 
     
     
         4 . A pharmaceutical composition comprising the compound of  claim 1 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient. 
     
     
         5 . The pharmaceutical composition of  claim 4 , wherein said compound is an acetate salt. 
     
     
         6 . The pharmaceutical composition of  claim 4 , wherein said compound is a chloride salt. 
     
     
         7 . The pharmaceutical composition of  claim 4 , wherein said pharmaceutical composition is formulated for oral administration. 
     
     
         8 . The pharmaceutical composition of  claim 4 , wherein said pharmaceutical composition is formulated for intravenous administration. 
     
     
         9 . The pharmaceutical composition of  claim 4 , wherein said pharmaceutical composition is formulated for topical administration. 
     
     
         10 . The pharmaceutical composition of  claim 4 , wherein said pharmaceutical composition is formulated for subcutaneous administration. 
     
     
         11 . The pharmaceutical composition of  claim 4 , wherein said pharmaceutical composition is formulated for inhalation. 
     
     
         12 . A method of treating a fungal infection in a subject, said method comprising administering to said subject a pharmaceutical composition of  claim 4  in an amount sufficient to treat said infection. 
     
     
         13 . The method of  claim 12 , wherein said pharmaceutical composition is administered orally. 
     
     
         14 . The method of  claim 12 , wherein said pharmaceutical composition is administered intravenously. 
     
     
         15 . The method of  claim 12 , wherein said pharmaceutical composition is administered topically. 
     
     
         16 . The method of  claim 12 , wherein said pharmaceutical composition is administered subcutaneously. 
     
     
         17 . The method of  claim 12 , wherein said pharmaceutical composition is administered by inhalation. 
     
     
         18 . The method of  claim 12 , wherein said pharmaceutical composition is administered to treat a blood stream infection or tissue infection in said subject. 
     
     
         19 . The method of  claim 12 , wherein said infection is selected from tinea capitis, tinea corporis, tinea pedis, onychomycosis, perionychomycosis, pityriasis versicolor, oral thrush, vaginal candidosis, respiratory tract candidosis, biliary candidosis, eosophageal candidosi, urinary tract candidosis, systemic candidosis, mucocutaneous candidosis, aspergillosis, mucormycosis, paracoccidioidomycosis, North American blastomycosis, histoplasmosis, coccidioidomycosis, sporotrichosis, fungal sinusitis, or chronic sinusitis. 
     
     
         20 . The method of  claim 12 , wherein wherein said fungal infection is an infection of  Candida albicans, C. parapsilosis, C. glabrata, C. guilliermondii, C. krusei, C. tropicalis, C. lusitaniae, Aspergillus fianigatus, A. flams, A. terretis, A. niger, A. Candidas, A. clavatus , or  A. ochraceus.    
     
     
         21 . A method of preventing a fungal infection in a subject, said method comprising administering to said subject a pharmaceutical composition of  claim 3  in an amount sufficient to prevent said infection. 
     
     
         22 . The method of  claim 21 , wherein said pharmaceutical composition is administered intravenously. 
     
     
         23 . The method of  claim 22 , wherein said subject is being prepared for an invasive medical procedure, said subject is immunocompromised, or said subject is undergoing long term antibiotic therapy. 
     
     
         24 . A method of preventing, stabilizing, or inhibiting the growth of fungi, or killing fungi, said method comprising contacting said fungi or a site susceptible to fungal growth with a compound of  claim 1 .