US2017258609A1PendingUtilityA1

Vessel remodeling methods and devices for use in a graft device

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Assignee: NEOGRAFT TECH INCPriority: Jul 25, 2011Filed: Jan 24, 2017Published: Sep 14, 2017
Est. expiryJul 25, 2031(~5 yrs left)· nominal 20-yr term from priority
Inventors:Jon McgrathMohammed S. El-KurdiLorenzo SolettiJ. Christopher Flaherty
A61B 2017/1132A61B 17/11A61L 27/3687A61B 2017/00969A61F 2/82A61L 27/3625A61B 2017/1107A61B 2017/22097A61B 2017/00778A61L 27/507A61B 17/135A61B 17/00008A61L 27/3691
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Claims

Abstract

Methods and devices for treating a vessel for use in a medical procedure are disclosed. A vein or other vessel can be modified in situ, prior to harvesting. Subsequently, at least a portion of the vessel is removed, and subsequently implanted to treat a patient, typically in a bypass procedure in which the vessel portion fluidly connects a source of oxygenated blood to an occluded artery.

Claims

exact text as granted — not AI-modified
1 .- 128 . (canceled) 
     
     
         129 . A method of modifying an in situ vessel, the method comprising:
 modifying an in situ vessel; and   removing at least one segment of the modified in situ vessel;   wherein the in situ vessel modification is performed at least one week prior to removing the at least one vessel segment.   
     
     
         130 . The method of  claim 129 , further comprising applying a restrictive member about the at least one removed, modified in situ vessel segment to produce a covered graft device. 
     
     
         131 . The method of  claim 130 , wherein the restrictive member comprises a restrictive fiber matrix. 
     
     
         132 . The method of  claim 131 , wherein the restrictive member comprises a stent. 
     
     
         133 . The method of  claim 130 , wherein the in situ vessel comprises a vein. 
     
     
         134 . The method of  claim 130 , wherein the in situ vessel is selected from the group consisting of: vein, artery, urethra, intestine, esophagus, trachea, bronchi, ureter, duct, fallopian tube, and combinations of these materials. 
     
     
         135 . The method of  claim 130 , wherein the modification comprises increasing the pressure within the in situ vessel. 
     
     
         136 . The method of  claim 135 , wherein the pressure increase comprises an increase to at least 50 mmHg. 
     
     
         137 . The method of  claim 135 , wherein the pressure increase comprises a pressure that is varied over time. 
     
     
         138 . The method of  claim 135 , wherein the pressure is incrementally increased over time. 
     
     
         139 . The method of  claim 130 , wherein the modification comprises applying a pressure applying cuff to a patient's skin proximate the in situ vessel. 
     
     
         140 . The method of  claim 139 , wherein the cuff further comprises an inflatable bladder. 
     
     
         141 . The method of  claim 140 , further comprising intermittently inflating the inflatable bladder such that pressure within the in situ vessel is intermittently elevated. 
     
     
         142 . The method of  claim 139 , wherein the pressure applying cuff causes the pressure within the in situ vessel to increase. 
     
     
         143 . The method of  claim 130 , wherein the modification comprises applying a vacuum around the in situ vessel. 
     
     
         144 . The method of  claim 130 , wherein the modification comprises implanting a mechanical scaffold within the in situ vessel. 
     
     
         145 . The method of  claim 130 , wherein the modification comprises implanting a flow occluding device proximate to the in situ vessel. 
     
     
         146 . The method of  claim 145 , wherein the modification comprises implanting the flow occluding device within a sidebranch proximate the in situ vessel. 
     
     
         147 . The method of  claim 145 , wherein the flow occluding device is constructed and arranged to at least partially occlude flow in a lumen of a vessel. 
     
     
         148 . The method of  claim 130 , wherein the modification comprises ligating at least one vessel sidebranch. 
     
     
         149 . The method of  claim 130 , wherein the modification comprises application of energy to the in situ vessel. 
     
     
         150 . The method of  claim 149 , wherein the energy comprises energy selected from the group consisting of: radiofrequency, ultrasound, chemical, laser, mechanical, and combinations of these. 
     
     
         151 . The method of  claim 149 , wherein the application of energy promotes angiogenesis. 
     
     
         152 . The method of  claim 129 , wherein the modification comprises modifying one or more valves of the in situ vessel. 
     
     
         153 . The method of  claim 129 , wherein the modification promotes angiogenesis. 
     
     
         154 . The method of  claim 129 , wherein the modification comprises delivering an agent into the in situ vessel.

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