Methods and Compositions for Improved Delivery Devices

Abstract

The present invention comprises methods and compositions for delivery devices More particularly, the present invention comprises methods and compositions for devices comprising a matrix comprising a polymer network and a non-gellable polysaccharide having oxygen and optionally active agents incorporated therein. The matrix may be formed into any desired shape for treatment of compromised tissue or for delivery of oxygen to a localized environment.

1 - 20 . (canceled) 
     
     
         21 . An oxygen-delivery wound treatment device, the device comprising:
 a) a formed biocompatible matrix comprising: a polymer, wherein the polymer comprises polyacrylamide, gelatin, agar, agarose, or a combination thereof; and a catalyst, wherein the matrix includes closed cells and walls;   b) gaseous oxygen, wherein the gaseous oxygen is contained in the closed cells; and   c) dissolved oxygen, wherein the dissolved oxygen is present in moisture in the walls, wherein the gaseous oxygen and the dissolved oxygen are produced when a peroxide is reacted with the catalyst.   
     
     
         22 . The device of  claim 21 , wherein the catalyst is present in the matrix in an amount ranging from about 0.005 wt. % to about 10 wt. % based on the total weight of the matrix. 
     
     
         23 . The device of  claim 21 , wherein the catalyst comprises sodium carbonate, cupric chloride, ferric chloride, manganese oxide, sodium iodide, lactoperoxidase, or a combination thereof. 
     
     
         24 . The device of  claim 21 , wherein the peroxide comprises hydrogen peroxide, ammonium peroxide, sodium peroxide, or a combination thereof. 
     
     
         25 . The device of  claim 21 , further comprising at least one active agent. 
     
     
         26 . The device of  claim 21 , wherein the matrix comprises a stranded configuration. 
     
     
         27 . The device of  claim 21 , further comprising a water loss control agent, wherein the water loss control agent comprises petrolatum, glycolipids, ceramides, free fatty acids, cholesterol, triglycerides, sterylesters, cholesteryl sulfate, linoleic ethyl ester, silicone oil, or a combination thereof. 
     
     
         28 . The device of  claim 21 , further comprising a plasticizer, wherein the plasticizer comprises glycerol, water, propylene glycol, butanol, or a combination thereof. 
     
     
         29 . The device of  claim 21 , further comprising a hydration control agent, wherein the hydration control agent comprises isopropyl alcohol, ethanol, glycerol, butanol, propylene glycol, or a combination thereof. 
     
     
         30 . The device of  claim 21 , further comprising a non-gellable polysaccharide. 
     
     
         31 . The device of  claim 30 , wherein the non-gellable polysaccharide comprises guar gum. 
     
     
         32 . The device of  claim 21 , wherein the polymer comprises polyacrylamide. 
     
     
         33 . The device of  claim 32 , wherein the polyacrylamide is cross-linked. 
     
     
         34 . The device of  claim 21 , wherein the device comprises residual peroxide. 
     
     
         35 . The device of  claim 21 , wherein the device comprises residual catalyst. 
     
     
         36 . The device of  claim 21 , wherein the oxygen-delivery wound treatment device maintains delivery of oxygen for at least 24 hours 
     
     
         37 . An oxygen-delivery wound treatment device, the device comprising:
 a) a formed biocompatible matrix comprising: a polymer, wherein the polymer comprises polyacrylamide, gelatin, agar, agarose, or a combination thereof; and a catalyst, wherein the matrix includes closed cells and walls;   b) gaseous oxygen, wherein the gaseous oxygen is contained in the closed cells; and   c) dissolved oxygen, wherein the dissolved oxygen is present in moisture in the walls, wherein the gaseous oxygen and the dissolved oxygen are produced when a peroxide is reacted with the catalyst, wherein the oxygen-delivery wound treatment device maintains delivery of oxygen for at least 24 hours.   
     
     
         38 . The device of  claim 37 , wherein the catalyst is present in the matrix in an amount ranging from about 0.005 wt. % to about 10 wt. % based on the total weight of the matrix. 
     
     
         39 . The device of  claim 37 , wherein the catalyst comprises sodium carbonate, cupric chloride, ferric chloride, manganese oxide, sodium iodide, lactoperoxidase, or a combination thereof. 
     
     
         40 . The device of  claim 37 , wherein the peroxide comprises hydrogen peroxide, ammonium peroxide, sodium peroxide, or a combination thereof. 
     
     
         41 . The device of  claim 21 , wherein the catalyst is inorganic. 
     
     
         42 . The device of  claim 37 , wherein the catalyst is inorganic.