Annexin a2 as immunological target

Abstract

AnnexinA2 (ANXA2), a member of the Annexin family of calcium-dependent, phospholipid binding proteins, is one of a panel of identified antigens recognized by the post-vaccination sera of patients who demonstrated prolonged disease-free survival following multiple vaccinations. AnnexinA2 is abundantly expressed in pancreatic adenocarcinomas and cell surface/membrane AnnexinA2 increases with the progression from premalignant lesions to invasive pancreatic adenocarcinomas. The cytoplasmic to cell surface translocation of AnnexinA2 expression is critical for pancreatic cancer cell invasion. In addition, phosphorylation of AnnexinA2 at Tyrosine 23 is important for its localization to the cell surface and for the invasion of pancreatic cancer cells. Finally, loss of AnnexinA2 leads to the loss of the Epithelial-Mesenchymal Transition.

1 .- 14 . (canceled) 
     
     
         15 . A vaccine for treating patients with a tumor which has been resected, comprising: ANXA2 or a nucleic acid encoding ANXA2. 
     
     
         16 . The vaccine of  claim 15  which comprises a nucleic acid encoding ANXA2. 
     
     
         17 . The vaccine of  claim 15  which comprises a ANXA2.