Benzimidazole Inhibitors of the Sodium Channel

Abstract

The invention relates to compounds useful in treating conditions associated with voltage-gated ion channel function, particularly conditions associated with sodium channel activity. More specifically, the invention concerns compounds (e.g., compounds according to any of Formulas (I)-(XIII) or Compounds (1)-(236) of Table 1) that are useful in treatment of a variety of diseases and conditions.

What is claimed is: 
     
         1 . A compound having a structure according to the following formula, 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt or solvate thereof, wherein
 each of R 1 , R 2 , and R 3  is, independently, H, unsubstituted C1-C6 alkyl, optionally substituted C1-C6 haloalkyl, or halogen; 
 m is 1 or 2; 
 each R 4  and R 5  is, independently, H, optionally substituted C1-C6 alkyl, or optionally substituted C1-C6 haloalkyl, or R 4  and R 5  combine to form an optionally substituted C3-C6 cycloalkyl, or R 4  and R 5  combine to form an oxo (C═O) group; 
 each of R 6  and R 8  is, independently, H or optionally substituted C1-C6 alkyl; or R 6  and R 8  combine to form an optionally substituted three-to-nine membered heterocyclyl, or R 6  and R 7A  combine to form an optionally substituted three-to-nine membered heterocyclyl; 
 n is 1 or 2; 
 
       each R 7A  and R 7B  is, independently H, optionally substituted C1-C6 alkyl, or optionally substituted C1-C6 haloalkyl; or R 6  combines with R 7A  to form an optionally substituted three-to-nine heterocyclyl; or an R 7A  and R 7B  group on the same carbon combine to form an optionally substituted C3-C6 cycloalkyl; or, when n is 2, both R 7A  groups combine to form an optionally substituted C3-C6 cycloalkyl.