Resorbable cellulose based biomaterial and implant

Abstract

The present disclosure describes an implant for tissue replacement or augmentation including a resorbable non-pyrogenic porous body of irradiated oxidized cellulose, formed from a precursor reactive mixture of irradiated cellulose and an oxidizing agent, where the body forms a heterogeneous three-dimensional fibrillar network.

1 . (canceled) 
     
     
         2 . An implant for soft tissue repair comprising:
 an oxidized film of irradiated microbial cellulose;   wherein the film is porous and resorbable;   wherein the film has a hydrated state upon exposure to fluid; and,   wherein the film in the hydrated state is configured to conform to a soft tissue surface.   
     
     
         3 . The implant of  claim 2 , wherein the film has a cellulose content in the range of about 2 mg/cm 2  to about 15 mg/cm 2 . 
     
     
         4 . The implant of  claim 2 , further comprising an active agent. 
     
     
         5 . The implant of  claim 4 , wherein the film is configured as a scaffold for the active agent. 
     
     
         6 . The implant of  claim 4 , wherein the active agent is impregnated within the film. 
     
     
         7 . The implant of  claim 4 , wherein the active agent is coated onto the film. 
     
     
         8 . The implant of  claim 2 , wherein the film comprises an active agent impregnated within the film, and wherein the film comprises an active agent coated onto the film. 
     
     
         9 . The implant of  claim 2 , wherein the film in the hydrated state is configured to self-adhere to the soft tissue surface. 
     
     
         10 . The implant of  claim 2 , wherein the implant is configured as a hemostat. 
     
     
         11 . The implant of  claim 2 , further comprising a secondary implantable device. 
     
     
         12 . The implant of  claim 11 , wherein the film is configured as a hemostat. 
     
     
         13 . The implant of  claim 2 , wherein the film has an in vitro degradation rate in one week under simulated body fluid (SBF) conditions of about zero percent to about 90 percent. 
     
     
         14 . The implant of  claim 2 , wherein the film has an in vitro degradation rate in four weeks under simulated body fluid (SBF) conditions of about 80 percent to about 100 percent. 
     
     
         15 . The implant of  claim 2 , wherein the film has an in vitro degradation rate under simulated body fluid (SBF) conditions such that the film remains mechanically stable at least between 2 weeks to four weeks. 
     
     
         16 . The implant of  claim 2 , wherein the film, in the hydrated state, has a burst strength in the range of about 3 N to about 30 N. 
     
     
         17 . A method for repair of a soft tissue comprising:
 attaching a porous oxidized film of irradiated microbial cellulose to a surface of a soft tissue, wherein the film has a hydrated state upon exposure to fluid;   wherein attaching the film in the hydrated state to the surface of the soft tissue conforms the film to the surface of the soft tissue; and,   wherein, after attaching, the film in the hydrated state is self-adhering to the surface of the soft tissue.   
     
     
         18 . The method of  claim 17 , wherein the film is configured as a hemostat. 
     
     
         19 . The method of  claim 17 , wherein the film further comprises an active agent. 
     
     
         20 . The method of  claim 19 , wherein the active agent is impregnated within the film. 
     
     
         21 . The method of  claim 19 , wherein the active agent is coated onto the film. 
     
     
         22 . The method of  claim 17 , wherein the film is resorbable, and has an in vitro degradation rate in four weeks under simulated body fluid (SBF) conditions of about 80 percent to about 100 percent. 
     
     
         23 . The implant of  claim 17 , wherein the film, in the hydrated state, has a burst strength in the range of about 3 N to about 30 N.