Markers Associated With Arteriovascular Events And Methods Of Use Thereof

Abstract

Disclosed are methods of identifying subjects with arteriovascular disease, subjects at risk for developing arteriovascular disease, methods of differentially diagnosing diseases associated with arteriovascular disease from other diseases or within sub-classifications of arteriovascular disease, methods of evaluating the risk of arteriovascular events in patients with arteriovascular disease, methods of evaluating the effectiveness of treatments in subjects with arteriovascular disease, and methods of selecting therapies for treating arteriovascular disease.

1 . A method for evaluating the risk of a cardiovascular event for a subject comprising measuring at least three component ARTERIORISKMARKERS for the individual selected from the component ARTERIORISKMARKERS within the groups consisting of Core Markers I, Core Markers II, Traditional Laboratory Risk Factors, Clinical Parameters, Supplemental Markers I, and Supplemental Markers II, provided at least one component ARTERIORISKMARKER is selected from the component ARTERIORISKMARKERS within Core Markers I. 
     
     
         2 . The method of  claim 1 , comprising measuring at least two component ARTERIORISKMARKERS within Core Markers I. 
     
     
         3 . The method of  claim 1 , comprising measuring at least three component ARTERIORISKMARKERS within Core Markers I. 
     
     
         4 . The method of  claim 1  wherein the component ARTERIORISKMARKER selected from Core Marker I is POMC. 
     
     
         5 - 16 . (canceled) 
     
     
         17 . A method for evaluating the risk of a cardiovascular event for a subject comprising measurement of POMC for the individual. 
     
     
         18 - 20 . (canceled) 
     
     
         21 . The method of  claim 17  comprising measurement of at least one of HDLC Age, BMI, VEGF, CCL2, IL6ST, IL18, LEP for the subject. 
     
     
         22 - 26 . (canceled) 
     
     
         27 . A kit comprising reagents for the detection or quantification of two or more component ARTERIORISKMARKERS selected from the group consisting of POMC, HDLC, VEGF, CCL2, IL6ST, IL8, and LEP. 
     
     
         28 . The kit of  claim 27  for the detection or quantification of three or more of the component ARTERIORISKMARKERS selected from the group consisting of POMC, HDLC, VEGF, CCL2, IL6ST, IL8, and LEP. 
     
     
         29 . The kit of  claim 27  for the detection or quantification of four or more of the component ARTERIORISKMARKERS selected from the group consisting of POMC, HDLC, VEGF, CCL2, IL6ST, IL8, and LEP. 
     
     
         30 . The kit of  claim 27  comprising reagents for the detection or quantification of markers selected from POMC and HDLC, POMC and VEGF, POMC and CCL2, HDLC and VEGF, HDLC and CCL2, or VEGF and CCL2. 
     
     
         31 - 42 . (canceled) 
     
     
         43 . The method of  claim 1  wherein the measurement of at least one of the component ARTERIORISKMARKERS selected is unaffected by treatment of the subject with one or more therapeutic interventions. 
     
     
         44 . The method of  claim 1  wherein the measurement of at least one of the component ARTERIORISKMARKERS selected is affected by treatment of the subject with one or more therapeutic interventions. 
     
     
         45 - 59 . (canceled)