Bacteriotherapy for clostridium difficile colitis

Abstract

This document discusses, among other things, receiving a plurality of donor fecal samples from a plurality of donors and storing and indexing each respective donor fecal samples using at least one characteristic of the respective donor fecal sample. In an example, the donor fecal sample can be screened and processed for subsequent use in fecal bacteriotherapy to displace pathogenic or undesired organisms in the digestive track of a patient with healthy or desirable gut microbiota.

What is claimed is: 
     
         1 . A bacteriotherapy bank, comprising:
 a temperature specific storage device;   a plurality of microbiota restoration therapy compositions disposed in the temperature specific storage device;   wherein the plurality of microbiota restoration therapy compositions include a first microbiota restoration therapy composition and a second microbiota restoration therapy composition;   wherein the first microbiota restoration therapy composition comprises a first processed fresh human fecal sample from a first donor mixed with a cryoprotectant;   wherein the cryoprotectant includes a glycol;   wherein the second microbiota restoration therapy composition comprises a second processed fresh human fecal sample from a second donor mixed with the cryoprotectant;   wherein the first microbiota restoration therapy composition is indexed by a first characteristic of the first donor; and   wherein the second microbiota restoration therapy composition is indexed by a second characteristic of the second donor.   
     
     
         2 . The bacteriotherapy bank of  claim 1 , wherein the plurality of microbiota restoration therapy compositions are stored in patient deliverable form. 
     
     
         3 . The bacteriotherapy bank of  claim 2 , wherein the patient deliverable form comprises an ingestible capsule. 
     
     
         4 . The bacteriotherapy bank of  claim 2 , wherein the patient deliverable form comprises a microbiota restoration therapy composition in a nasogastric (NG) tube. 
     
     
         5 . The bacteriotherapy bank of  claim 2 , wherein the patient deliverable form comprises a microbiota restoration therapy composition in a vial for use with a retention enema. 
     
     
         6 . The bacteriotherapy bank of  claim 1 , wherein the first characteristic of the first donor and/or the second characteristic of the second donor comprises a geographic location of the first and/or second donor, a diet of the first and/or second donor, an ethnicity of the first and/or second donor, age, sex, health status, medical history, and/or a physical characteristic of the first and/or second donor. 
     
     
         7 . The bacteriotherapy bank of  claim 6 , wherein the physical characteristic comprises a body type, weight, height, and/or body mass index. 
     
     
         8 . The bacteriotherapy bank of  claim 6 , wherein the medical history includes the presence or absence of a medical condition of the donor. 
     
     
         9 . The bacteriotherapy bank of  claim 8 , wherein the medical includes at least one of a metabolic disorder or a digestive disorder. 
     
     
         10 . The bacteriotherapy bank of  claim 1 , wherein the plurality of microbiota restoration therapy compositions are indexed using a computer-based indexing system. 
     
     
         11 . The bacteriotherapy bank of  claim 1 , wherein the temperature specific storage device is configured to store the plurality of microbiota restoration therapy compositions at a temperature of about −20° Celsius. 
     
     
         12 . A bacteriotherapy bank, comprising:
 a temperature specific storage device;   a plurality of microbiota restoration therapy compositions in a patient deliverable form disposed in the temperature specific storage device, wherein each of the plurality of microbiota restoration therapy compositions are manufactured by:
 collecting a fresh human fecal sample from a single donor; 
 adding a diluent including a cryoprotectant in saline to the fresh human fecal sample to form a diluted sample; 
 homogenizing the human fecal sample and the diluent to form a diluted sample; 
 filtering the diluted sample to form a filtrate comprising a microbiota restoration therapy composition; 
   wherein the plurality of microbiota restoration therapy compositions include microbiota restoration therapy compositions that are manufactured from two or more different donors and are indexed by one or more characteristics of the two or more donors; and   wherein the one or more characteristics of the two or more donors comprises a geographic location of the donor, a donor's diet, an ethnicity of the donor, age, sex, health status, medical history, and/or a physical characteristic of the donor.   
     
     
         13 . The bacteriotherapy bank of  claim 12 , wherein the temperature specific device is configured to store the microbiota restoration therapy compositions at temperature conditions for maintaining viability of a microbiota in the therapy. 
     
     
         14 . The bacteriotherapy bank of  claim 12 , wherein the plurality of microbiota restoration therapy compositions are stored in a plurality of storage containers. 
     
     
         15 . The bacteriotherapy bank of  claim 12 , wherein the patient deliverable form comprises an ingestible capsule. 
     
     
         16 . The bacteriotherapy bank of  claim 12 , wherein the patient deliverable form comprises a microbiota restoration therapy composition in a nasogastric (NG) tube. 
     
     
         17 . The bacteriotherapy bank of  claim 12 , wherein the patient deliverable form comprises a microbiota restoration therapy composition in a vial for use with a retention enema. 
     
     
         18 . The bacteriotherapy bank of  claim 12 , wherein the physical characteristic comprises a body type, weight, height, and/or body mass index. 
     
     
         19 . A bacteriotherapy bank, comprising:
 a temperature specific storage device;   a plurality of microbiota restoration therapy compositions in a patient deliverable form including an ingestible capsule, a microbiota restoration therapy composition in a nasogastric (NG) tube, and/or a microbiota restoration therapy composition in a nasogastric (NG) tube disposed in the temperature specific storage device, wherein each of the plurality of microbiota restoration therapy compositions are manufactured by:
 collecting a fresh human fecal sample from a single donor; 
 adding a diluent including a cryoprotectant in saline to the fresh human fecal sample to form a diluted sample; 
 homogenizing the human fecal sample and the diluent to form a diluted sample; 
 filtering the diluted sample to form a filtrate comprising a microbiota restoration therapy composition; 
   wherein the plurality of microbiota restoration therapy compositions include microbiota restoration therapy compositions that are manufactured from two or more different donors and are indexed by one or more characteristics of the two or more donors; and   wherein the one or more characteristics of the two or more donors comprises a geographic location of the donor, a donor's diet, an ethnicity of the donor, age, sex, health status, medical history, and/or a physical characteristic of the donor.   
     
     
         20 . The bacteriotherapy bank of  claim 19 , wherein the temperature specific device is configured to store the microbiota restoration therapy compositions at temperature conditions for maintaining viability of a microbiota in the therapy.