Methods and compositions for personalized medicine by point-of-care devices for brain natriuretic peptide

Abstract

Methods, devices, reagent, systems and kits for the detection, diagnosis of ovarian cancer as well as for the monitoring of ovarian cancer progression and for monitoring the progress of ovarian cancer treatments using BNP as a biomarker.

The embodiments of the invention in which an exclusive property or privilege is claimed are defined as follows: 
     
         1 . A method for diagnosing the presence of ovarian cancer in a subject, comprising determining the level of brain natriuretic peptide (BNP) in the subject and comparing the level(s) of the biomarker(s) in the subject with the normal level of BNP. 
     
     
         2 . The method of  claim 1 , wherein the level of biomarker in the subject is at least 10% less than the normal level. 
     
     
         3 . The method of  claim 1 , wherein the level of biomarker in the subject is at least 50% less than the normal level. 
     
     
         4 . The method of  claim 1 , wherein the determination of the level of biomarker in the patient is performed by a quantitative point-of-care device. 
     
     
         5 . The method of  claim 4 , wherein the point-of-care device is a lateral flow device. 
     
     
         6 . A method for monitoring the progression of ovarian cancer in a patient diagnosed with ovarian cancer, comprising determining the level of BNP in the patient at a first point in time and comparing the level of BNP in the subject at a second point in time to determine the progression of the ovarian cancer. 
     
     
         7 . The method of  claim 6 , wherein the level of biomarker in the subject is at least 10% less than the normal level. 
     
     
         8 . The method of  claim 6 , wherein the level of biomarker in the subject is at least 50% less than the normal level. 
     
     
         9 . The method of  claim 6 , wherein the determination of the level of biomarker in the patient is performed by a quantitative point-of-care device. 
     
     
         10 . The method of  claim 9 , wherein the POC device is a lateral flow device. 
     
     
         11 . A kit for biomarker monitoring of an individual treated with an ovarian cancer treatment, the kit comprising:
 a plurality of point-of-care devices or a point-of-use device capable of quantitating BNP in one or more blood samples.   
     
     
         12 . The kit of  claim 11 , further comprising instructions for collecting the at least two samples. 
     
     
         13 . The kit of  claim 11 , wherein the point-of-care device is an expanded range, lateral flow device.