Therapeutic astaxanthin and phospholipid composition and associated method

Abstract

A dietary supplement includes comprising a therapeutic amount of astaxanthin derived from a synthetic or natural ester or diol, and at least one of a phospholipid, glycolipid, and sphingolipid, and formulated into an oral dosage form, wherein the astaxanthin is 0.1 to 15 percent by weight of the at least one phospholipid, glycolipid, and sphingolipid. The composition includes 0.5 to 12 mg of astaxanthin and may be used to treat low density lipoprotein (LDL) oxidation in humans and other diseases, disorders and impairments.

That which is claimed is: 
     
         1 . A dietary supplement composition formulated in a therapeutic effective amount to treat low density lipoprotein (LDL) peroxidation in humans composition comprising 0.5 to 12 mg of astaxanthin derived from  Haematococcus pluvialis  (Hp), and 50 to 500 mg of a lipid selected from the group consisting of a phospholipid, glycolipid, and sphingolipid, wherein the astaxanthin is 0.1 to 15 percent by weight of the lipid selected from the group consisting of a phospholipid, glycolipid and sphingolipid, and wherein the composition is formulated into an oral dosage form as a single dosage capsule. 
     
     
         2 . The composition according to  claim 1 , wherein the composition further comprises a pharmaceutical or food grade diluent. 
     
     
         3 . The composition according to  claim 1 , wherein the phospholipid is selected from the group consisting of Phosphatidylcholine, Phosphatidylethanolamine, Phosphatidylserine, Phosphatidylinositol, Phosphatidic acid, Lysophosphatidylcholine, Lysophosphatidylethanolamine, and Lysophosphatidylserine. 
     
     
         4 . The composition according to  claim 1 , wherein the phospholipid comprises at least one of a plant, algae and animal source derivative. 
     
     
         5 . The composition according to  claim 1 , wherein the composition has the astaxanthin dispersed into the selected lipid under high shear conditions. 
     
     
         6 . A dietary supplement composition formulated in a therapeutic effective amount to treat low density lipoprotein (LDL) peroxidation in humans comprising 0.5 to 12 mg of astaxanthin derived from  Haematococcus pluvialis  (Hp) and 50 to 500 mg of a phospholipid, wherein the astaxanthin is 0.1 to 15 percent by weight of the phospholipid and wherein the composition is formulated into an oral dosage form as a single dosage capsule. 
     
     
         7 . The composition according to  claim 6 , wherein the composition further comprises a pharmaceutical or food grade diluent. 
     
     
         8 . The composition according to  claim 6 , wherein the phospholipid is selected from the group consisting of Phosphatidylcholine, Phosphatidylethanolamine, Phosphatidylserine, Phosphatidylinositol, Phosphatidic acid, Lysophosphatidylcholine, Lysophosphatidylethanolamine, and Lysophosphatidylserine. 
     
     
         9 . The composition according to  claim 6 , wherein the phospholipid comprises at least one of a plant, algae or animal source derivative. 
     
     
         10 . The composition according to  claim 6 , wherein the composition has the astaxanthin dispersed into the selected lipid under high shear conditions.