Cyclic peptide derivative, method for preparing same and composition thereof

Abstract

Provided is a cyclic peptide derivative which is derived from Paecilomyces tenuipes having an astrocyte proliferative activity, or a salt thereof.

1 . A cyclic peptide derivative represented by the following general formula (1), 
       
         
           
           
               
               
           
         
         (in the formula, m is 0 to 3, n≧1, R 1  to R 6  are a hydrogen atom or a hydrocarbon group, R 7  and R 8  are a carboxyl group or a salt thereof, or an alkoxycarbonyl group, R 9  is a hydrocarbon group, a hydroxyl group, an alkoxy group, or an alkylcarbonyloxy group, R 10  and R 11  are a hydrogen atom, a hydrocarbon group, or an alkylcarbonyloxy group, and R 12  to R 16  are a hydrogen atom or a hydrocarbon group). 
       
     
     
         2 . The cyclic peptide derivative according to  claim 1 , wherein, in the general formula (1), R 1 , R 2 , R 3 , and R 4  are an alkyl group, n=2 to 4, R 5  and R 6  are a hydrogen atom, and R 7  are R 8  a carboxyl group. 
     
     
         3 . A method for preparing a cyclic peptide derivative in which the cyclic peptide derivative according to  claim 1  is collected from  Paecilomyces tenuipes.    
     
     
         4 . The method for preparing a cyclic peptide derivative according to  claim 3 , wherein  Paecilomyces tenuipes  is artificially cultured  Paecilomyces tenuipes  by using pupae of silkworm as medium. 
     
     
         5 . The method for preparing a cyclic peptide derivative according to  claim 3 , wherein the method comprises a hot water extraction step of  Paecilomyces tenuipes  powder. 
     
     
         6 . (canceled) 
     
     
         7 . A pharmaceutical composition comprising the cyclic peptide derivative according to  claim 1  or a salt thereof as an effective component. 
     
     
         8 . The pharmaceutical composition according to  claim 7 , wherein the composition has an astrocyte proliferative activity. 
     
     
         9 . The pharmaceutical composition according to  claim 7 , wherein the composition increases an expression level of NGF gene and VGF gene. 
     
     
         10 . The pharmaceutical composition according to  claim 7 , wherein the composition has an activity of improving a brain function. 
     
     
         11 . The pharmaceutical composition according to  claim 7 , wherein the composition has an activity of improving hair texture. 
     
     
         12 . (canceled)