Modified adeno-associated virus vector compositions

Abstract

An adeno-associated virus filler component comprising a nucleic acid of between 3300 and 4200 nucleotides in length is disclosed.

What is claimed is: 
     
         1 . An adeno-associated virus (AAV) filler component comprising a nucleic acid of between 3300 and 4200 nucleotides in length having at least 90% identity to SEQ ID NO:1 or SEQ ID NO:2. 
     
     
         2 . An adeno-associated virus (AAV) filler component consisting of a nucleic acid of between 3300 and 4200 nucleotides in length having at least 90% identity to SEQ ID NO:1 or SEQ ID NO:2. 
     
     
         3 . The AAV filler component of  claim 1  or  claim 2 , wherein the nucleic acid is between 3500 and 4000 nucleotides. 
     
     
         4 . The AAV filler component of  claim 1  or  claim 2 , wherein the nucleic acid is between 3700 and 3850 nucleotides. 
     
     
         5 . The AAV filler component of any one of  claims 1  to  4 , wherein the nucleic acid has at least 95% identity to SEQ ID NO:1 or SEQ ID NO:2. 
     
     
         6 . An adeno-associated virus (AAV) vector comprising the filler component of any one of  claims 1  to  5  operably linked to an expression cassette. 
     
     
         7 . The AAV vector of  claim 6 , wherein the expression cassette comprises a promoter. 
     
     
         8 . The AAV vector of  claim 7 , wherein the promoter is a pol III promoter. 
     
     
         9 . The AAV vector of  claim 8 , wherein the promoter is a mU6 promoter. 
     
     
         10 . The AAV vector of any one of  claims 6  to  9  further comprising a target sequence. 
     
     
         11 . The AAV vector of  claim 10 , wherein the target sequence is an RNAi molecule.