Formulations and Methods of Administration of Cephalotaxines, Including Homoharringtonine

Abstract

The present invention is directed to compositions and methods for the treatment of patients with cephalotaxines, for example, homoharringtonine. The invention is also directed to improvements in the purity, manufacturing process, formulation and administration of homoharringtonine for the treatment of cancer and other aberrant cellular diseases. The invention also provides methods and compositions for antiparasitic, antifungal, antiviral and antibacterial treatments.

1 .- 28 . (canceled) 
     
     
         29 . An oral dosage form comprising a therapeutically effective dose of homoharringtonine and microcrystalline cellulose. 
     
     
         30 . The oral dosage form of  claim 29 , comprising about 2 percent to about 60 percent by weight homoharringtonine. 
     
     
         31 . The oral dosage form of  claim 29 , comprising a tablet unit form or capsule unit form. 
     
     
         32 . A liquid dosage form comprising an aqueous solution of homoharringtonine and a pH of about 4.0, wherein the aqueous solution of homoharringtonine exhibits less than a 5% loss of potency as measured by high performance liquid chromatography upon storage for 7 weeks at 60° C. 
     
     
         33 . The liquid dosage form of  claim 32 , wherein the concentration of homoharringtonine is between 0.1 mg/mL and 50 mg/mL. 
     
     
         34 . The liquid dosage form of  claim 32 , wherein the concentration of homoharringtonine is between 1 and 5 mg/mL. 
     
     
         35 . The liquid dosage form of  claim 32 , comprising a phosphate buffer.