Systems and methods for limb treatment

Abstract

A method of delivering a medicament to a limb of a patient body includes isolating a circulatory system of the limb from a circulatory system of the patient body, wherein the limb circulatory system is substantially all limb arteries and substantially all limb veins located between an isolation region and an end of the limb. A perfusion catheter is inserted into a limb artery in an antegrade position, while a collection catheter is inserted into a limb vein in a retrograde position. The blood flow of the limb circulatory system is then circulated by collecting the blood flow with the collection catheter and delivering the blood flow with the perfusion catheter. A medicament is perfused into the limb circulatory system with the perfusion catheter.

What is claimed is: 
     
         1 .- 18 . (canceled) 
     
     
         19 . A system for perfusing a limb, comprising:
 a) an infusion catheter adapted to be placed into a limb vein in a retrograde position, wherein the infusion catheter comprises:
 i) a distal elongate portion defining a plurality of infusion ports, said elongate portion ports configured to span longitudinally at least two venous valves; 
 ii) a proximal expandable element, said element positioned proximal to the distal elongate portion and configured to occlude the vein during infusion of the vein with the infusion catheter; 
   b) a collection catheter adapted to be placed into a limb artery in an antegrade position, wherein the collection catheter comprises:
 i) a distal portion defining at least one collection port, and an expandable element disposed proximal of the at least one distal collection port, said expandable element configured to occlude the artery during collection from the artery with the collection catheter; 
   c) a recirculating apparatus configured to venously deliver oxygenated medium to the infusion catheter, and arterially collect medium from the artery of the collection catheter, when the limb is substantially isolated from systemic blood flow during expansion of the collection catheter and infusion catheter expandable members.   
     
     
         20 . The system of claim  1 , wherein the infusion catheter expandable element is movably positionable along the delivery portion of the infusion catheter, including the elongate portion. 
     
     
         21 . The system of claim of  2 , wherein the infusion expandable element is located on the delivery end of the infusion catheter so as to at least partially occlude at least one of the plurality of openings of the delivery end of the perfusion catheter. 
     
     
         22 . The system of claim  1 , wherein the recirculating apparatus is configured to allow infusion of a medicant in addition to any medium collected from the collection catheter.