US2017327456A1PendingUtilityA1

Process for making modulators of cystic fibrosis transmembrane conductance regulator

Assignee: VERTEX PHARMAPriority: Mar 20, 2009Filed: Aug 2, 2017Published: Nov 16, 2017

Est. expiryMar 20, 2029(~2.6 yrs left)· nominal 20-yr term from priority

Inventors:John Demattei Adam Looker Bobbianna Neubert-Langille Martin Trudeau Stefanie Roeper Michael P. Ryan Dahrika Milfred Yap Guerette Brian R. Krueger Peter D.J. Grootenhuis Fredrick Van Goor Martyn Botfield Gregor Zlokarnik

A61P 7/10A61P 7/12A61P 9/00A61P 37/06A61P 5/18A61P 5/00A61P 3/10A61P 7/00A61P 5/10A61P 3/08A61P 5/48A61P 7/04A61P 37/08A61P 37/00A61P 43/00A61P 3/06A61P 7/02A61P 5/16A61P 31/10A61P 3/02A61P 35/00A61P 27/04A61P 25/00A61P 25/28A61P 25/14A61P 3/00A61P 27/02A61P 25/16A61P 25/02A61P 21/02A61P 11/02A61P 1/16A61P 21/00A61P 11/00A61P 1/10A61P 19/08A61P 13/12A61P 1/18A61P 17/00A61P 11/06A61P 11/08A61P 15/08A61P 21/04A61P 1/00A61P 15/10C07D 215/233C07C 213/02G01N 33/5041C07C 69/96A61K 31/4704C07C 201/08C07D 215/56C07C 68/02G01N 33/6872Y02P20/55C07C 229/66C07C 205/43

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Claims

Abstract

The invention provides a process for the preparation of a compound of Formula 1, comprising coupling a carboxylic acid of Formula 2 with an aniline of Formula 3 in the presence of a coupling agent.

Claims

exact text as granted — not AI-modified

What is claimed is: 
     
         1 . A compound having the formula: 
       
         
           
           
               
               
           
         
       
     
     
         2 . A pharmaceutically acceptable salt of a compound having the formula:

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