Liver X Receptor (LXR) Modulators For The Treatment Of Dermal Diseases, Disorders And Conditions

Abstract

Described herein are liver X receptor (LXR) modulators and methods of milizing LXR modulators in the treatment of dermal diseasess, disorders or conditions. Also described herein are pharmaceutical compositions containg such compounds.

1 . A compound having the structure of Formula (A): 
       
         
           
           
               
               
           
         
       
       wherein:
 X is —O— or or —S—; 
 A and B are each nitrogen, wherein A and B are bonded together to form a five-membered heteroaryl ring; 
 L 1  and L 2  are each independently a bond, C 1 -C 6 alkyl, or C 1 -C 6 heteroalkyl; 
 R 1  is hydrogen, halogen, —CF 3 , —OR 8 , —N(R 8 ) 2 , —C(═O) R 8 , —C(═O)OR 8 , —C(═O)N(R 8 ) 2 , —C(═N—OH) R 8 , —C(═S)N(R 8 ) 2 , or —C(═O)OCH 2 SCH 3 ; 
 R 2  is —OR 9 , —N(R 9 ) 2 , —C(═O)R 9 , —C(═O)OR 9 , —C(═O)N(R 9 ) 2 , —NR 10 C(═O)R 9 , —C(═N—OH)R 9 , —C(═S)N(R 9 ) 2 , —C(═O)OCH 2 SCH 3 , C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, C 1 -C 6 haloalkyl, C 1 -C 6 heteroalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl; 
 R 3  is hydrogen, halogen, C 1 -C 6 alkyl, or C 1 -C 6 haloalkyl; 
 R 4  is aryl or heteroaryl; wherein aryl or heteroaryl is substituted with at least one R 11 ; 
 each R 8 , each R 9 , and each R 10  are each independently hydrogen, C 1 -C 6 alkyl, C 1 -C 6 heteroalkyl, —C 1 -C 6 alkyl-aryl, aryl, or heteroaryl; 
 R 11  is independently halogen, nitro, —OR 10 , —N(R 10 ) 2 , —CN, —C(═O)R 10 , —C(═O)OR 10 , —C(═O)N(R 10 ) 2 , —NR 10 C(═O) R 10 , NR 10 SO 2 R 10 , —SOR 10 , —SO 2 R 10 , —SO 2 (R 10 ) 2 , —C(═O)OCH 2 SCH 3 , C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, C 1 -C 6 haloalkyl, C 1 -C 6 heteroalkyl, —C 1 -C 6  alkyl-aryl, optionally substituted aryl, or optionally substituted heteroaryl; 
 or a pharmaceutically acceptable salt, pharmaceutically acceptable solvate, or pharmaceutically acceptable prodrug thereof. 
 
     
     
         2 .- 46 . (canceled)