N-carbamoylputrescine to enhance muscle protein synthesis

Abstract

The present invention relates to the field of food supplement and medicament supporting muscle metabolism, more precisely muscle protein synthesis. In particular, the invention relates to a composition comprising N-carbamoylputrescine (NCP). The invention further relates to the non-therapeutic use of N-carbamoylputrescine (NCP) to enhance muscle protein synthesis in a subject. Moreover, the invention also relates to N-carbamoylputrescine for its use as a medicament.

1 . An edible product comprising a pharmaceutically acceptable salt of N-carbamoylputrescine of formula (I) 
       
         
           
           
               
               
           
         
       
     
     
         2 . An edible product according to  claim 1 , comprising an enteric vehicle. 
     
     
         3 . An edible product according to  claim 1 , wherein said edible product is a food product or a beverage product. 
     
     
         4 . An edible product according to  claim 1 , further comprising L-amino-acids, polyamines, carbohydrate compounds, or combinations thereof. 
     
     
         5 . An edible product according to  claim 4 , wherein the L-amino-acid is histidine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, valine, alanine, arginine, citrulline, asparagine, aspartic acid, cysteine, glutamic acid, glutamine, glycine, ornithine, proline, serine, tyrosine, argininosuccinate, or decarboxylated forms thereof and deaminated forms thereof. 
     
     
         6 . An edible product according to  claim 4 , wherein the polyamine is putrescine, spermine, spermidine, or agmatine. 
     
     
         7 . An edible product according to  claim 4 , wherein the carbohydrate compound is glucose, fructose, galactose, or polysaccharides thereof. 
     
     
         8 . A topical cosmetic composition comprising N-carbamoylputrescine and/or one of its salts, and a cosmetically acceptable excipient. 
     
     
         9 - 12 . (canceled) 
     
     
         13 . A composition comprising a pharmaceutically acceptable salt of N-carbamoylputrescine. 
     
     
         14 - 15 . (canceled) 
     
     
         16 . An edible product according to  claim 2 , wherein said edible product is a food product or a beverage product. 
     
     
         17 . An edible product according to  claim 1 , wherein said edible product is a medicament. 
     
     
         18 . An edible product according to  claim 2 , wherein said edible product is a medicament. 
     
     
         19 . The topical cosmetic composition of  claim 8 , said composition comprising a pharmaceutically acceptable salt of N-carbamoylputrescine. 
     
     
         20 . The topical cosmetic composition of  claim 8 , wherein said topical cosmetic composition is a powder, aerosol, plaster lotion, liniment, solution, emulsion, suspension, ointment, cream, paste or gel. 
     
     
         21 . The composition of  claim 13 , further comprising a pharmaceutically acceptable carrier.