Small molecule inhibitors of viral protein interactions with human t-rna

Abstract

Disclosed herein are compounds, compositions and methods of their use to treat HIV/AIDS disease in a subject in need thereof, wherein the compositions comprise small molecule inhibitors that inhibit viral preparation or viral recruitment of human tRNA 3 Lys .

What is claimed is: 
     
         1 . A method of treating HIV/AIDS disease in a patient in need thereof, said method comprising administering a therapeutically effective amount of one or more compounds of formula (IV), (V) or (VI). 
     
     
         2 . The method according to  claim 1  wherein said compound of formula (IV), (V) or (VI) is selected from the group consisting of 8391-1, 8391-2, 8391-3, 8391-4, 8391-5, 8391-6, 8391-7, 8391-8, 8391-9, 8391-10, 8391-11, 8391-12, 8391-13, 8391-14, 8391-15, 8391-16, 8391-17, 8391-18, 8391-19, 8391-20, 8391-21. 
     
     
         3 . The method according to  claim 1 , wherein said patient is administered a therapeutically effective amount of one or more compounds of formula V or VI. 
     
     
         4 . The method according to  claim 3 , wherein said compound of formula V or VI is selected from the group consisting of 8391-6, 8391-7, 8391-10 and 8391-12. 
     
     
         5 . The method according to  claim 1 , wherein HIV/AIDS is treated by inhibiting interaction of one or more viral and/or host proteins with human tRNA in a subject in need thereof. 
     
     
         6 . A method of inhibiting viral preparation or viral recruitment of tRNA 3 Lys comprising contacting said tRNA 3 Lys with one or more compound of formula (IV), (V) or (VI) in an amount effective to inhibit viral preparation or viral recruitment of tRNA 3 Lys. 
     
     
         7 . The method according to  claim 6  wherein said compound of formula (IV), (V) or (VI) is selected from the group consisting of 8391-1, 8391-2, 8391-3, 8391-4, 8391-5, 8391-6, 8391-7, 8391-8, 8391-9, 8391-10, 8391-11, 8391-12, 8391-13, 8391-14, 8391-15, 8391-16, 8391-17, 8391-18, 8391-19, 8391-20, 8391-21. 
     
     
         8 . The method according to  claim 6 , wherein viral preparation or viral recruitment of tRNA 3 Lys is inhibited by contacting said tRNA 3 Lys with one or more compounds of formula V or VI. 
     
     
         9 . The method according to  claim 8 , wherein said compound of formula V or VI is selected from the group consisting of 8391-6, 8391-7, 8391-10 and 8391-12.