Chinese medicinal composition for preventing or treating cardiovascular and cerebrovascular diseases or dementia, and preparation method and use thereof

Abstract

Disclosed are a Chinese medicinal composition for preventing or treating cardiovascular and cerebrovascular diseases and/or dementia, and a preparation method and use thereof. The composition is prepared from the following medical raw materials in parts by weight: 1 part of ginseng , 0.8-1.5 parts of ginkgo leaf and 0.018-0.030 part of stigma croci.

1 . A Chinese medicinal composition for preventing or treating cardiovascular and cerebrovascular disease and/or dementia, the raw material that make the Chinese medicinal composition is the medicine with the following weight ratio of ingredients:
 1 part of  ginseng,  0.8-1.5 parts of ginkgo leaf, 0.018-0.030 part of stigma croci.   
     
     
         2 . The Chinese medicinal composition according to  claim 1 , characterized in that the raw material that make the Chinese medicinal composition is the medicine with the following weight ratio of ingredients:
 1 part of  ginseng,  1 part of ginkgo leaf, 0.018-0.030 part of stigma croci.   
     
     
         3 . The Chinese medicinal composition according to  claim 1 , characterized in that the raw material that make the Chinese medicinal composition is the medicine with the following weight ratio of ingredients:
 1 part of  ginseng,  0.9-1.2 parts of ginkgo leaf, 0.020-0.025 part of stigma croci.   
     
     
         4 . The Chinese medicinal composition according to  claim 3 , characterized in that the raw material that make the Chinese medicinal composition is the medicine with the following weight ratio of ingredients:
 1 part of  ginseng,  1 part of ginkgo leaf, 0.020-0.025 part of stigma croci.   
     
     
         5 . The Chinese medicinal composition according to  claim 4 , characterized in that the raw material that make the Chinese medicinal composition is the medicine with the following weight ratio of ingredients:
 1 part of  ginseng,  1 part of ginkgo leaf, 0.022 part of stigma croci.   
     
     
         6 . A method of preparing the Chinese medicinal composition of  claim 1 , comprising a step of weighing  ginseng , ginkgo leaf and stigma croci, a step of preparing  ginseng  extract, a step of preparing ginkgo leaf extract, a step of preparing stigma croci extract, a step of mixing the above  ginseng  extract, the ginkgo leaf extract and the stigma croci extract. 
     
     
         7 . The method according to  claim 6 , characterized in that in the step of the preparing  ginseng  extract, a main component obtained is total ginsenosides; in the step of preparing Ginkgo leaf extract, a main component obtained is Ginkgo leaf total flavonoids and total lactones; in the step of preparing stigma croci extract, a main component obtained is stigma croci total glycosides. 
     
     
         8 . The method according to  claim 7 , characterized in that the steps for preparing the  ginseng  extract are:
 the  ginseng  is grinded into powders, then subjected to reflux extraction with ethanol for 2 times, filtered, the filtrate obtained is decompressed to recover the solvent until the relative density is 1.12-1.14 at 70° C., water with the amount that equals to 2-6 times of that of crude drug is added for stirring homogeneously, then it is cooled for precipitation, the supernatant is loaded onto a macroporous adsorptive resin, the resin that carries drug is washed with distilled water first, then is eluted with ethanol, the ethanol eluent is collected and concentrated until dry to obtain the  ginseng  extract;   the steps for preparing the Ginkgo leaf extract are: warm ethanol is added to Ginkgo leaf coarse powder for immersion, filtered, and the filter residue is immersed with warm ethanol, filtered again, the filtrates obtained are combined, and concentrated under reduced pressure until the relative density is 1.12-1.14 at 70° C., water with the amount that equals to 2-6 times of that of crude drug is added, stirred homogeneously, then cooled for precipitation, filtered, the filtrate is loaded onto a macroporous adsorptive resin, the resin that carries drug is washed with distilled water first, then is eluted with ethanol, the ethanol eluent is collected and concentrated until the relative density is 1.02-1.04 at 70° C., it is extracted by ethyl acetate:n-butyl alcohol, the extracts are combined and are decompressed to recover solvent to obtain Ginkgo leaf extract; and   the steps for preparing the stigma croci extract are: cold ethanol is added into stigma croci crude drug for immersion, then filtered, cold ethanol is added to the residues for immersion again, then filtered, the filtrates obtained are combined, concentrated under reduced pressure until the relative density is 1.12-1.14 at 70° C., water is added, then it is loaded onto a macroporous adsorptive resin, the resin that carries drug is washed with distilled water first, then is eluted with ethanol, the ethanol eluent is concentrated until the relative density is 1.02-1.04 at 70° C., it is concentrated until dry to obtain stigma croci extract.   
     
     
         9 . A Chinese medicinal formulation for preventing or treating cardiovascular and cerebrovascular diseases and/or dementia which is composed of the Chinese medicinal composition according to  claim 1 , and at least one pharmaceutically acceptable excipient. 
     
     
         10 . A method for preventing or treating cardiovascular and cerebrovascular diseases and/or dementia in a subject, comprising administering to a subject in need thereof the Chinese medicinal composition according to  claim 1 . 
     
     
         11 . The method according to  claim 10 , wherein the cardiovascular and cerebrovascular disease is selected from the group consisting of ischemic cerebrovascular disease, coronary heart disease, angina, and combinations thereof. 
     
     
         12 . The method according to  claim 10 , wherein the dementia is senile dementia. 
     
     
         13 . The method according to  claim 12 , wherein the senile dementia is vascular dementia.