Wound Healing Composition Involving Mineral Ions and Methylglyoxal, and Methods of Use

Abstract

The invention provides compositions based on an effective amount of an active anti-inflammatory ingredient of mineral solids fortified with methylglyoxal antibacterial activity for the treatment of wounds; and methods of treating a wound, comprising contacting a wound with the above compositions or a wound dressing containing the above compositions.

The invention claimed is: 
     
         1 . A wound healing composition, comprising:
 a pharmaceutically acceptable carrier;   an effective amount of an active ingredient of mineral solids, said mineral solids including at least one of a magnesium salt, a potassium salt, a calcium salt, a zinc salt, a rubidium salt, a bromide salt, and a sulfate salt; and   a concentration of methylglyoxal effective to reduce a number of microorganisms at a wound site being added to said active ingredient.   
     
     
         2 . The wound healing composition of  claim 1 , wherein each of the salts includes a pharmaceutically-acceptable counterion. 
     
     
         3 . The wound healing composition of  claim 1 , wherein the active ingredient of mineral solids includes 1.5-75 parts of magnesium ions, 0.5-75 parts of potassium ions, 0.001-10 parts of calcium ions, 0.0001-10 parts of zinc ions, up to 5 parts of rubidium ions, 0.001-20 parts of bromide ions, and up to 20 parts of sulfate ions, said parts expressing a mass of a respective ions divided by a total mass of the mineral solids. 
     
     
         4 . The wound healing composition of  claim 1 , wherein said methylglyoxal added to said active ingredient ranges from 500 to 2000 mg per kg of the composition. 
     
     
         5 . The wound healing composition of  claim 1 , wherein the pharmaceutically-acceptable carrier includes at least one of water, polyethylene glycol, an ointment, and a cream base. 
     
     
         6 . The wound healing composition of  claim 1 , wherein a pH of the composition is between 3.0-7.0. 
     
     
         7 . The wound healing composition of  claim 1 , wherein the wound healing composition is replaced on a wound at least once. 
     
     
         8 . A wound healing dressing, comprising:
 the wound healing composition according to  claim 1 ; and   a support.   
     
     
         9 . The wound healing dressing of  claim 8 , wherein the support includes at least one of a fibrous gauze material, a hydrogel, a foam, a film, a hydrocolloid, a collagen, and an alginate.