Transfusion Registry Network Providing Real-time Interaction Between Users and Providers of Genetically Characterized Blood Products

Abstract

Disclosed is a registry system, including member institutions, in which transfusion donors and recipients are registered following genotyping, which would typically take place in a member institution, or a member institution would have access to the genotyping information, if performed outside. The registry database can be accessed and searched by members seeking samples of particular type(s). Systems are disclosed for maintaining economic viability of genotyping in connection with transfusions, by maximizing the number of units placed with the minimal number of candidate donors typed. Genotyping of potential donors, and product supply, is matched to forecasted demand. Genotyping can also be limited to the more clinically relevant markers. The registry system can also be integrated with one format of assay which generates an image for analysis, whereby the imaged results can be analyzed and redacted by experts in a central location, and then transmitted back to the patient or their representative.

1 - 9 . (canceled) 
     
     
         10 . A strategy for reducing the cost of genotyping of candidate donors and maximizing the matching of candidate donors and recipients, comprising:
 stratifying prospective donors and recipients into subpopulations;   determining, in each subpopulation, genetic markers which are associated with clinically significant adverse events; and   matching donors and recipients for those markers which have a significance greater than a particular level.   
     
     
         11 . The strategy of  claim 10  wherein donors and recipients are not genotypes for markers with a significance below the particular level. 
     
     
         12 - 19 . (canceled) 
     
     
         20 . A method for operating a transfusion registry that matches donors compatible to recipients of given genotype or phenotype comprising:
 estimating anticipated demand for blood products from transfusion recipients of given genotype or phenotype, wherein the anticipated demand is estimated using the formula:
   ε˜( N   (Rs)   /N   (R) ) f   (s) Σ( r )
 
   
       wherein ε is the probability of logging a request for a specific genotype, the ratio N (Rs) /N (R)  represents the relative proportion of individuals in an ethnic heritage group within a population at large, f (s)  represents the frequency of occurrence of a certain allele, and Σ(r) represents a function of excess risk for requiring transfusions associated with the ethnic heritage group relative to the population at large, and wherein using the formula comprises obtaining values for N (Rs) /N (R) , f (s)  and Σ(r);
 genotyping a sufficient number of prospective donors to fulfill the anticipated demand; and 
 matching donors compatible to recipients of given genotype or phenotype. 
 
     
     
         21 . The method of  claim 20 , wherein the genotyping is performed by an elongation-mediated multiplexed analysis of polymorphisms. 
     
     
         22 . The method of  claim 21  further comprising collecting samples from the prospective donors prior to the step of genotyping. 
     
     
         23 . The method of  claim 20 , wherein the genotyping is of one or more of markers RhCE, Kidd, Kell, Duffy, Dombrock, and MNS.