US2018015011A1PendingUtilityA1

Composition for preventing or treating dental erosion

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Assignee: MEDA OTC ABPriority: Jun 18, 2014Filed: Jul 31, 2017Published: Jan 18, 2018
Est. expiryJun 18, 2034(~7.9 yrs left)· nominal 20-yr term from priority
Inventors:Thomas BerglundGunilla Johansson-Rudén
A61P 43/00A61P 1/02A61K 31/19A61K 33/16A61Q 11/00A61K 6/60A61K 6/70A61K 8/21A61K 8/368A61K 8/362A61K 8/44A61K 8/365A61K 8/36A61K 8/37
38
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Claims

Abstract

The present invention related to a composition of pH in the range 2.0 to 4.5 comprising at least one fluoride source and at least one other agent for use in prevention and/or treatment of dental erosion.

Claims

exact text as granted — not AI-modified
1 - 10 . (canceled) 
     
     
         11 . A method for preventing and/or treating dental erosion; preventing demineralization or subsurface demineralization of the dental enamel; and/or enhancing remineralization of the dental enamel or the subsurface dental enamel, comprising administering to a subject in need thereof a composition comprising,
 at least one fluoride source selected from hydrofluoric acid (HF), one or more bifluoride(s) or a mixture thereof; and   at least one organic acid or salt thereof, wherein at least one pKa of the organic acid is in the range from 2 to 6;   wherein the pH of the composition is in the range from 2.0 to 4.5, for use in.   
     
     
         12 . The method of  claim 11 , wherein the pH of the composition is in the range from 2.5 to 4.0. 
     
     
         13 . The method of  claim 11 , wherein the pH of the composition is in the range from 3.0 to 3.5. 
     
     
         14 . The method of  claim 11 , wherein the pH of the composition is about 3.5. 
     
     
         15 . The method of  claim 11 , wherein the total amount of fluoride present in the composition is from about 0.01% to about 4.0% by weight. 
     
     
         16 . The method of  claim 11 , wherein the total amount of fluoride present in the composition is from about 0.01% to about 2.0% by weight. 
     
     
         17 . The method of  claim 11 , wherein the total amount of fluoride present in the composition is from about 0.01% to about 1.0% by weight. 
     
     
         18 . The method of  claim 11 , wherein the total amount of fluoride present in the composition is from about 0.01% to about 0.5% by weight. 
     
     
         19 . The method of  claim 11 , wherein the total amount of fluoride present in the composition is from about 0.01% to about 0.05% by weight. 
     
     
         20 . The method of  claim 11 , wherein the total amount of fluoride present in the composition is less than 0.05% by weight. 
     
     
         21 . The method of  claim 11 , wherein the fluoride source is HF. 
     
     
         22 . The method of  claim 11 , wherein the fluoride source is a bifluoride selected from the group consisting of NaHF2, KHF2, NH4HF2, and any mixtures thereof. 
     
     
         23 . The method of  claim 11 , wherein the organic acid or salt thereof is selected from the group consisting of benzoic acid, sodium benzoate, glycine, glycolic acid, glutamic acid, lactic acid, and any mixtures thereof. 
     
     
         24 . The method of  claim 11 , wherein the organic acid or salt thereof is selected from the group consisting of benzoic acid, sodium benzoate, glycine, and any mixtures thereof. 
     
     
         25 . The method of  claim 11 , wherein the fluoride source is HF and the organic acid or salt thereof is a mixture of sodium benzoate and glycine. 
     
     
         26 . The method of  claim 11 , wherein the fluoride source is a bifluoride and the organic acid or salt thereof is a mixture of sodium benzoate and glycine. 
     
     
         27 . The method of  claim 11 , wherein the composition is in the form of an aqueous solution, a gel, a foam, a dentifrice, a dental varnish, or a toothpaste.

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