Methods of Treating Prostate Cancer

Abstract

Disclosed are methods of treating prostate cancer by administering niraparib to a human in need thereof.

1 . A method of treating prostate cancer in a human in need of such treatment comprising administering to the human a safe and effective amount of niraparib. 
     
     
         2 . A method of  claim 1 , wherein the prostate cancer is castration-resistant prostate cancer or metastatic castration-resistant prostate cancer. 
     
     
         3 . A method of  claim 2 , wherein the prostate cancer is antiandrogen resistant. 
     
     
         4 . A method as in  claim 3 , wherein the human is carrying at least one DNA repair anomaly selected from the group consisting of BRCA-1, BRCA-2, FANCA, PALB2, CHEK2, HDAC2, and ATM. 
     
     
         5 . A method of  claim 4 , where in the DNA repair anomaly is BRCA-1 or BRCA-2. 
     
     
         6 . A method of  claim 5 , wherein the prostate cancer is castration-resistant prostate cancer. 
     
     
         7 . A method of  claim 5 , wherein the prostate cancer is metastatic castration-resistant prostate cancer. 
     
     
         8 . A method of  claim 6 , wherein niraparib is administered in an amount of from about 30 mg/day to about 400 mg/day. 
     
     
         9 . A method of  claim 8 , wherein the amount of niraparib administered is about 300 mg/day. 
     
     
         10 . A method of  claim 9 , wherein niraparib is administered as once daily oral administration in three 100 mg oral dosage forms. 
     
     
         11 . A method of treating castration and anti androgen resistant prostate cancer in a human comprising administering three 100 mg oral dosage forms niraparib once daily to the human.