Transdermal therapeutic system comprising buprenorphrine

Abstract

The invention is concerned with a transdermal therapeutic system (TTS) comprising buprenorphine and a method of manufacturing such a TTS. The transdermal therapeutic system is used for the transdermal administration of buprenorphine and analogues thereof. In particular, the invention relates to the use of a transdermal therapeutic system (TTS) for analgesic purposes. The TTS according to the invention comprises a transdermal drug delivery composition comprising buprenorphine and an adhesive component, which is a mixture of a crosslinked and a non-crosslinked acrylic polymer and a penetration enhancer comprising a keto acid.

1 - 12 . (canceled) 
     
     
         13 . A method of producing a transdermal therapeutic system comprising a backing layer, at least one adhesive layer and a release liner, comprising the steps of
 1) preparing a solution comprising
 a. buprenorphine, 
 b. a crosslinkable acrylic polymer, 
 c. a non-crosslinkable acrylic polymer, and 
 d. a penetration enhancer comprising a keto acid, and 
 e. optionally one or more of a solubilizer or tackifier, 
   2) coating the solution on the backing layer or on the release liner,   3) drying the coating to form the at least one adhesive layer, and   4) coating the at least one adhesive layer with the release liner or the backing layer.   
     
     
         14 . The method according to  claim 13 , wherein crosslinking of the crosslinkable acrylic polymer occurs when drying the solution. 
     
     
         15 . A transdermal therapeutic system obtainable by the method of  claim 13 .