Composition Comprising Neoagarooligosaccharide As Active Ingredient, For Prevention or Treatment of Sepsis or Septic Shock

Abstract

The present invention relates to a composition for prevention or treatment of sepsis or septic shock, in which the composition includes neoagarooligosaccharide as an active ingredient, and the neoagarooligosaccharide according to the present invention has an excellent effect in terms of immune enhancement by effectively suppressing inflammation, and also exhibits a good effect in preventing sepsis, and therefore can be effectively used in pharmaceuticals and functional foods for prevention or treatment of sepsis or septic shock and immune enhancement.

1 . A pharmaceutical composition for prevention or treatment of sepsis or septic shock, the pharmaceutical composition comprising neoagarooligosaccharide, which is prepared from agar or agarose by a DagA enzyme reaction, as an active ingredient. 
     
     
         2 . The pharmaceutical composition of  claim 1 , wherein the DagA enzyme is derived from  Streptomyces coelicolor.    
     
     
         3 . The pharmaceutical composition of  claim 2 , wherein the DagA enzyme is represented by amino acid sequences 31 to 309 of SEQ ID NO: 2. 
     
     
         4 . The pharmaceutical composition of  claim 2 , wherein the DagA enzyme is encoded by a nucleotide sequence of SEQ ID NO: 1. 
     
     
         5 . The pharmaceutical composition of  claim 1 , wherein the enzyme reaction is carried out at a temperature of 35° C. to 45° C. and pH of 6 to 8. 
     
     
         6 . The pharmaceutical composition of  claim 1 , wherein the neoagarooligosaccharide is one or more kinds selected from the group consisting of neoagarobiose, neoagarotetraose, and neoagarohexaose. 
     
     
         7 . A food composition for prevention or ameliorating sepsis or septic shock, the food composition comprising neoagarooligosaccharide prepared from agar or agarose by DagA enzyme reaction as an active ingredient. 
     
     
         8 . A pharmaceutical composition for reinforcement of immunization, the pharmaceutical composition comprising neoagarooligosaccharide prepared from agar or agarose by a DagA enzyme reaction, as an active ingredient. 
     
     
         9 . A functional food for reinforcement of immunization, the functional food comprising neoagarooligosaccharide prepared from agar or agarose by a DagA enzyme reaction, as an active ingredient.