Therapeutical methods, formulations and nutraceutical formulations

Abstract

The invention provides compositions and methods for the prevention, treatment, or management of sexual dysfunction, such as premature ejaculation. The method comprises administering an effective amount of tetrahydropalmatine or its derivative or Rhizoma Corydalis extract containing composition to a human male on an as-needed basis shortly before sexual activity to delay ejaculation.

What is claimed is: 
     
         1 . A method of managing sexual dysfunction or improving sexual control in a mammal in need of treatment comprising administering on an as-needed basis to the mammal a composition comprising tetrahydropalmatine and serotonin reuptake inhibitor in a therapeutically effective amount. 
     
     
         2 . The method of  claim 1 , wherein the mammal is a human male. 
     
     
         3 . The method of  claim 1 , wherein the serotonin reuptake inhibitor is selected from a group consisting of St. John's Wort extract, hyperforin, paroxetine, sertraline, dapoxetine, escitalopram and citalopram. 
     
     
         4 . A method of managing sexual dysfunction or improving sexual control in a mammal in need of treatment comprising administering on an as-needed basis to the mammal a composition comprising  Corydalis Yanhusuo  extract in a therapeutically effective amount. 
     
     
         5 . The method of  claim 4 , wherein the composition further comprise St. John's Wort extract. 
     
     
         6 . The method of  claim 4 , wherein the composition further comprise curcuminoid. 
     
     
         7 . A formulation for delaying ejaculation comprising  Corydalis  extract or tetrahydropalmatine, curcuminoid and at least one agent selected from a group consisting of paroxetine, sertraline, dapoxetine, Escitalopram, Citalopram and St. John's Wort extract. 
     
     
         8 . The formulation of  claim 7  wherein the curcuminoid is selected from a group consisting of curcumin, desmethoxycurcumin, bis-desmethoxycurcumin, tetrahydrocurcuminoid, curcumin glucuronide, curcumin sulfate, hexahydrocurcumin or combinations thereof. 
     
     
         9 . The formulation of  claim 7 , wherein the St. John's Wort extract is rich in hyperforin.