Agents and methods for modulating the sensory impact of tobacco or herbal smoke

Abstract

A combustible device includes a wrapper, tobacco disposed in the wrapper, and an agent that activates a TRPA1 channel disposed in the wrapper.

What is claimed is: 
     
         1 . A device, comprising:
 a wrapper;   tobacco disposed in the wrapper; and   a first agent that activates a TRPA1 channel disposed in the wrapper.   
     
     
         2 . The device of  claim 1 , wherein the first agent includes at least one of grains of paradise, galangal and 6-paradol. 
     
     
         3 . The device of  claim 1 , wherein the device is at least partially combustible. 
     
     
         4 . The device of  claim 1 , further comprising a filter disposed toward an end of the device and coupled to the wrapper. 
     
     
         5 . The device of  claim 4 , further comprising a capsule operable to be broken by finger pressure. 
     
     
         6 . The device of  claim 5 , wherein
 the first agent is disposed in the tobacco, and   a second agent that activates at least one of a TRPM8 channel, a TRPV3 channel, and a TRPV1 channel is disposed in the capsule.   
     
     
         7 . The device of  claim 6 , wherein the second agent activates the TRPM8 channel and is operable to provide a cooling sensation. 
     
     
         8 . The device of  claim 7 , wherein the second agent includes at least one of menthol, physcool (monomenthyl succinate), icilin, geraniol, linalool, hydroxycitronellal, WS-3, WS-23, PMD38, Cool-actP, FrescolatMGA, FrescolatMA and PMD38. 
     
     
         9 . The device of  claim 6 , wherein the second agent activates the TRPV3 channel and is operable to provide a warming sensation. 
     
     
         10 . The device of  claim 9 , wherein the second agent includes at least one of carvacrol, thymol, eugenol, eucalyptol, incensol, borneol, camphor, dihydrocarveol. 
     
     
         11 . The device of  claim 6 , wherein the second agent activates the TRPV1 channel 
     
     
         12 . The device of  claim 11 , wherein the second agent includes at least one of Szechuan pepper, all spice, mustard and rosemary. 
     
     
         13 . The device of  claim 1 , further comprising a second agent that activates a TRPM8 channel and is operable to provide a cooling sensation. 
     
     
         14 . The device of  claim 1 , further comprising a second agent that activates a TRPV3 channel and is operable to provide a warming sensation. 
     
     
         15 . The device of  claim 1 , further comprising a second agent that activates the TRPV1 channel. 
     
     
         16 . The device of  claim 1 , wherein the tobacco is a low nicotine tobacco. 
     
     
         17 . The device of  claim 16 , further comprising at least one of herb and tea leaves. 
     
     
         18 . A device, comprising:
 a wrapper;   at least one of herb and tea leaves disposed in the wrapper; and   a first agent that activates a TRPA1 channel disposed in the wrapper.   
     
     
         19 . The device of  claim 18 , wherein the first agent includes at least one of grains of paradise, galangal and 6-paradol. 
     
     
         20 . The device of  claim 18 , further comprising a capsule operable to be broken by finger pressure, wherein
 the first agent is disposed in the at least one of herb and tea leaves, and   a second agent that activates at least one of a TRPM8 channel, a TRPV3 channel, and a TRPV1 channel is disposed in the capsule.   
     
     
         21 . The device of  claim 20 , wherein the second agent activates the TRPM8 channel and is operable to provide a cooling sensation. 
     
     
         22 . The device of  claim 20 , wherein the second agent activates the TRPV3 channel and is operable to provide a warming sensation. 
     
     
         23 . The device of  claim 20 , wherein the second agent activates the TRPV1 channel. 
     
     
         24 . A composition, comprising:
 at least one of tobacco, herb and tea leaves;   a first agent that activates a TRPA1 channel intermixed with the at least one of tobacco, herb and tea leaves; and   a second agent, distinct from the first agent, that activates at least one of a TRPM8 channel, a TRPV3 channel, and a TRPV1 channel, wherein   the composition releases volatile compounds when heated at a temperature below a burning point of the composition.   
     
     
         25 . The composition of  claim 24 , wherein the first agent includes at least one of grains of paradise, galangal and 6-paradol. 
     
     
         26 . The device of  claim 24 , wherein the second agent activates the TRPM8 channel and is operable to provide a cooling sensation. 
     
     
         27 . The device of  claim 24 , wherein the second agent activates the TRPV3 channel and is operable to provide a warming sensation. 
     
     
         28 . The device of  claim 24 , wherein the second agent activates the TRPV1 channel.