Composition comprising crepidiastrum denticulatum extract for preventing or treating ischemia-reperfusion injury and use thereof

Abstract

Provided are a pharmaceutical composition including a Crepidiastrum denticulatum extract as an active ingredient; and a method for preventing or treating ischemia-reperfusion injury in a subject by using a food composition or the pharmaceutical composition.

1 . A pharmaceutical composition comprising a  Crepidiastrum denticulatum  (CD) extract as an active ingredient for preventing or treating ischemia-reperfusion injury in a subject. 
     
     
         2 . The composition of  claim 1 , wherein the extract is extracted by using an extraction solvent comprising water, a C1-C6 alcohol, or a mixture thereof. 
     
     
         3 . The composition of  claim 1 , wherein the alcohol is methanol, ethanol, propanol, isopropanol, butanol, or a mixture thereof. 
     
     
         4 . The composition of  claim 1 , wherein ischemia is artificially induced. 
     
     
         5 . The composition of  claim 4 , wherein the artificially induced ischemia comprises artificially decreasing blood flow in a blood vessel. 
     
     
         6 . The composition of  claim 5 , wherein the artificial decreasing of the blood flow comprises clogging or blocking the blood vessel. 
     
     
         7 . The composition of  claim 5 , wherein the artificial decreasing of the blood flow is performed during surgery. 
     
     
         8 . The composition of  claim 7 , wherein the surgery comprises transplantation surgery, tissue resection, aneurysm repair surgery, or endarterectomy. 
     
     
         9 . The composition of  claim 8 , wherein the transplantation surgery comprises transplantation of heart, liver, kidney, lung, pancreas, stomach, small intestine, or large intestine. 
     
     
         10 . The composition of  claim 8 , wherein the tissue resection comprises resection of liver, kidney, lung, stomach, small intestine, or large intestine. 
     
     
         11 . The composition of  claim 1 , wherein the ischemia is caused by an ischemic disorder. 
     
     
         12 . The composition of  claim 1 , wherein the reperfusion is performed by artificial reperfusion. 
     
     
         13 . The composition of  claim 12 , wherein the artificial reperfusion comprises artificially increasing blood flow in a blood vessel. 
     
     
         14 . The composition of  claim 13 , wherein the artificial increasing of the blood flow comprises opening a clogged or closed blood vessel or connecting severed blood vessels. 
     
     
         15 . The composition of  claim 1 , wherein at least one of the ischemia and the reperfusion is artificially induced. 
     
     
         16 . The composition of  claim 1 , wherein the ischemia continues for about 10 minutes to about 60 minutes. 
     
     
         17 . The composition of  claim 1 , wherein the ischemia-reperfusion injury is injury to liver, kidney, heart, lung, small intestine, large intestine, or pancreas. 
     
     
         18 . The composition of  claim 1 , wherein administration of the composition is performed before, at the same time, or after the ischemia-reperfusion injury occurs. 
     
     
         19 . The composition of  claim 7 , wherein administration of the composition is performed before, at the same time, or after the surgery. 
     
     
         20 . A food composition including a  Crepidiastrum denticulatum  extract as an active ingredient for preventing or treating ischemia-reperfusion injury in a subject. 
     
     
         21 . A method of preventing or treating ischemia-reperfusion injury in a subject, the method comprising administering the composition of  claim 1  to the subject, wherein the subject is a mammal other than a human.