US2018086733A1PendingUtilityA1
Pyridinyl quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors

Assignee: FORMA THERAPEUTICS INCPriority: Sep 19, 2014Filed: Aug 15, 2017Published: Mar 29, 2018
Est. expirySep 19, 2034(~8.1 yrs left)· nominal 20-yr term from priority
Inventors:Jian Lin Anna Ericsson Ann-Marie Campbell Gary Gustafson Zhongguo Wang R. Bruce Diebold Susan Ashwell David R. Lancia, Jr.Justin Andrew Caravella Wei Lu
A61P 43/00A61P 7/00A61P 35/00A61P 35/02C07D 405/14A61P 1/16C07D 401/14A61P 25/00A61K 31/4704C07D 417/14C07D 401/12C07D 413/14A61P 19/08
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Abstract

The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: where A, B, U, V, Z, W 1 , W 2 , W 3 , and R 1 -R 6 are described herein.
Claims

exact text as granted — not AI-modified
1 - 42 . (canceled) 
     
     
         43 . A method of treating a cell proliferative disease comprising administering to a patient in need thereof a compound selected from the group consisting of:
 6-{[(1 S)-1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}-4-methoxypyridine-3-carbonitrile;   6-{[(1 S)-1-(6-chloro-1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}-4-methoxypyridine-3-carbonitrile;   6-{[(1R)-1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}-4-methoxypyridine-3-carbonitrile;   6-{[(1 S)-1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}-2-methylpyridine-3-carbonitrile;   6-{[(1 S)-1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}-4-methylpyridine-3-carbonitrile;   6-{[(1 S)-1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}-2-methoxypyridine-3-carbonitrile;   5-{[(1 S)-1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}-6-methoxypyridine-2-carbonitrile;   6-{[(1R)-1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}-2-methylpyridine-3-carbonitrile;   6-{[1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}-2-methylpyridine-3-carbonitrile;   6-chloro-3-[(1 S)-1-{[4-(2-oxo-1,3-oxazolidin-3-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[6-(2-oxo-1,3-oxazolidin-3-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-[6-methyl-4-(2-oxo-1,3-oxazolidin-3-yl)pyridin-2-yl]amino)ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[4-(4,4-dimethyl-2-oxo-1,3-oxazolidin-3-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[3-fluoro-4-(2-oxo-1,3-oxazolidin-3-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[3-methyl-4-(2-oxo-1,3-oxazolidin-3-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[4-fluoro-6-(2-oxo-1,3-oxazolidin-3-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[6-fluoro-4-(2-oxo-1,3-oxazolidin-3-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-3-[1-({4-[(4S)-2-oxo-4-(propan-2-yl)-1,3-oxazolidin-3-yl]pyridin-2-yl}amino)ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-({6-[(4S)-2-oxo-4-(propan-2-yl)-1,3-oxazolidin-3-yl]pyridin-2-yl}amino)ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1R)-1-({6-[(4S)-2-oxo-4-(propan-2-yl)-1,3-oxazolidin-3-yl]pyridin-2-yl}amino)ethyl]-1,2-dihydroquinolin-2-one;   6-{[1-(6-chloro-7-fluoro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}-2-methylpyridine-3-carbonitrile;   6-{[(1 S)-1-(6-chloro-7-fluoro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}-2-methylpyridine-3-carbonitrile;   6-{[(1 S)-1-(6-chloro-7-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}-2-methylpyridine-3-carbonitrile;   6-{[1-(6-chloro-7-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}-2-methylpyridine-3-carbonitrile;   6-{[(1 S)-1-(6-chloro-7-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}-4-methoxypyridine-3-carbonitrile;   6-{[(1 S)-1-(6-chloro-7-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}-2-methoxypyridine-3-carbonitrile;   6-{[(1 S)-1-(6-chloro-7-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}-4-methylpyridine-3-carbonitrile;   6-{[(1 S)-1-[6-chloro-2-oxo-7-(pyridin-2-ylmethoxy)-1,2-dihydroquinolin-3-yl]ethyl]amino}-2-methylpyridine-3-carbonitrile;   6-({1-[6-chloro-2-oxo-7-(pyridin-2-ylmethoxy)-1,2-dihydroquinolin-3-yl]ethyl}amino)-2-methylpyridine-3-carbonitrile;   6-[(1-{6-chloro-7-[(3,3-difluorocyclobutyl)methoxy]-2-oxo-1,2-dihydroquinolin-3-yl}ethyl)amino]-2-methylpyridine-3-carbonitrile;   6-{[1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)cyclopropyl]amino}-2-methylpyridine-3-carbonitrile;   6-{[2-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)propan-2-yl]amino}-2-methylpyridine-3-carbonitrile;   6-chloro-3-[(1 S)-1-({4-[(2-hydroxyethyl)amino]-6-methylpyridin-2-yl}amino)ethyl]-1,2-dihydroquinolin-2-one;   N-(2-{[(1 S)-1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}-3-fluoropyridin-4-yl)acetamide;   2-(6-{[(1 S)-1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}pyridin-2-yl)-1λ 6 ,2-thiazolidine-1,1-dione;   6-chloro-3-[(1 S)-1-({3-fluoro-4-[(2-hydroxyethyl)amino]pyridin-2-yl}amino)ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[3-fluoro-4-(1H-imidazol-1-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[3-fluoro-4-(4-methyl-1H-imidazol-1-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[4-(1,3-dimethyl-1H-pyrazol-5-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[4-(1,5-dimethyl-1H-pyrazol-4-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[4-(1H-pyrazol-5-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[3-fluoro-4-(1-methyl-1H-pyrrol-2-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-({4-[1-(2-methylpropyl)-1H-pyrazol-5-yl]pyridin-2-yl}amino)ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-({4-[1-(propan-2-yl)-1H-pyrazol-5-yl]pyridin-2-yl}amino)ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[4-(1,5-dimethyl-1H-pyrazol-4-yl)-3-fluoropyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[3-fluoro-4-(4-methylthiophen-3-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-({4-[1-(oxan-2-yl)-1H-pyrazol-5-yl]pyridin-2-yl}amino)ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[4-(4-methylthiophen-3-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[4-(1-methyl-1H-pyrazol-5-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-({4-[3-(trifluoromethyl)-1H-pyrazol-4-yl]pyridin-2-yl}amino)ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[4-(3,5-dimethyl-1H-pyrazol-4-yl)-3-fluoropyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[4-(1,3-dimethyl-1H-pyrazol-5-yl)-3-fluoropyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[3-fluoro-4-(1-methyl-1H-pyrazol-5-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[4-(dimethyl-1,2-oxazol-4-yl)-3-fluoropyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-({3-fluoro-4-[1-(oxan-2-yl)-1H-pyrazol-5-yl]pyridin-2-yl}amino)ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-({3-fluoro-4-[1-(2-methylpropyl)-1H-pyrazol-5-yl]pyridin-2-yl}amino)ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-({3-fluoro-4-[1-(propan-2-yl)-1H-pyrazol-5-yl]pyridin-2-yl}amino)ethyl]-1,2-dihydroquinolin-2-one;   6-{[(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)methyl]amino}-2-methylpyridine-3-carbonitrile;   6-{[(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)methyl]amino}-4-methylpyridine-3-carbonitrile;   6-{[(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)methyl]amino}-2-(trifluoromethyl)pyridine-3-carbonitrile;   5-{[(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)methyl]amino}-6-methoxypyridine-2-carbonitrile;   2-chloro-6-{[(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)methyl]amino}pyridine-3-carbonitrile;   6-{[(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)methyl]amino}-2-(2-oxo-1,3-oxazolidin-3-yl)pyridine-3-carbonitrile;   6-{[(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)methyl]amino}-2-[2-(propan-2-yl)pyrrolidin-1-yl]pyridine-3-carbonitrile;   6-{[(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)methyl]amino}-2-[methyl(2-methylpropyl)amino]pyridine-3-carbonitrile;   6-{[(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)methyl]amino}-2-methoxypyridine-3-carbonitrile;   6-{[(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)methyl]amino}pyridine-3-carbonitrile;   6-chloro-3-({[3-(propan-2-yl)pyridin-2-yl]amino}methyl)-1,2-dihydroquinolin-2-one;   6-chloro-3-{[(4,6-dimethylpyridin-2-yl)amino]methyl}-1,2-dihydroquinolin-2-one;   6-chloro-3-{[(4-methoxypyridin-2-yl)amino]methyl}-1,2-dihydroquinolin-2-one;   6-chloro-3-{[(5-fluoropyridin-2-yl)amino]methyl}-1,2-dihydroquinolin-2-one;   2-{[(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)methyl]amino}pyridine-4-carbonitrile;   methyl 6-{[(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)methyl]amino}pyridine-2-carboxylate;   6-chloro-3-{[(4-methylpyridin-2-yl)amino]methyl}-1,2-dihydroquinolin-2-one;   6-chloro-3-{[(5-chloropyridin-2-yl)amino]methyl}-1,2-dihydroquinolin-2-one;   6-chloro-3-{[(2-hydroxypyridin-3-yl)amino]methyl}-1,2-dihydroquinolin-2-one;   6-chloro-3-({[5-(trifluoromethyl)pyridin-2-yl]amino}methyl)-1,2-dihydroquinolin-2-one;   5-{[(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)methyl]amino}pyridine-2-carbonitrile;   6-chloro-3-({[4-(trifluoromethyl)pyridin-2-yl]amino}methyl)-1,2-dihydroquinolin-2-one;   6-{[(6,7-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]amino}pyridine-3-carbonitrile;   6-{[(6-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)methyl]amino}pyridine-3-carbonitrile;   6-methoxy-3-{[(4-methylpyridin-2-yl)amino]methyl}-1,2-dihydroquinolin-2-one;   6-{[(6-chloro-7-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)methyl]amino}-2-methylpyridine-3-carbonitrile;   6-({[6-chloro-2-oxo-7-(pyridin-2-ylmethoxy)-1,2-dihydroquinolin-3-yl]methyl}amino)-2-methylpyridine-3-carbonitrile;   6-[({6-chloro-7-[2-(4-methanesulfonylpiperazin-1-yl)ethoxy]-2-oxo-1,2-dihydroquinolin-3-yl}methyl)amino]-2-methylpyridine-3-carbonitrile;   Methyl N-(2-{[(1 S)-1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}pyridin-4-yl)carbamate;   2-{[(1 S)-1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}pyridine-4-carboxamide;   6-chloro-3-[(1 S)-1-{[4-(5-methyl-1H-1,2,3,4-tetrazol-1-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   N-(2-{[(1 S)-1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}pyridin-4-yl)acetamide;   6-chloro-3-[(1 S)-1-{[4-(1H-imidazol-1-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[4-(1,2-oxazol-4-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   3-[(1 S)-1-{[4-(1-benzyl-1H-imidazol-5-yl)pyridin-2-yl]amino}ethyl]-6-chloro-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[4-(1-methyl-1H-imidazol-5-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[4-(3-methylpyridin-4-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   N-(2-{[(1 S)-1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}pyridin-4-yl)-N-(2-methylpropyl)methanesulfonamide;   methyl N-(2-{[(1 S)-1-[6-chloro-2-oxo-7-(pyridin-2-ylmethoxy)-1,2-dihydroquinolin-3-yl]ethyl]amino}pyridin-4-yl)carbamate;   2-{[(1 S)-1-[6-chloro-2-oxo-7-(pyridin-2-ylmethoxy)-1,2-dihydroquinolin-3-yl]ethyl]amino}pyridine-4-carboxamide;   6-chloro-3-[(1 S)-1-{[3-fluoro-4-(2-oxo-1,3-oxazolidin-3-yl)pyridin-2-yl]amino}ethyl]-7-(pyridin-2-ylmethoxy)-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[4-(5-methyl-1H-1,2,3,4-tetrazol-1-yl)pyridin-2-yl]amino}ethyl]-7-(pyridin-2-ylmethoxy)-1,2-dihydroquinolin-2-one;   N-(2-{[(1 S)-1-[6-chloro-2-oxo-7-(pyridin-2-ylmethoxy)-1,2-dihydroquinolin-3-yl]ethyl]amino}pyridin-4-yl)acetamide;   6-chloro-3-[(1 S)-1-{[4-(1H-imidazol-1-yl)pyridin-2-yl]amino}ethyl]-7-(pyridin-2-ylmethoxy)-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[4-(1,2-oxazol-4-yl)pyridin-2-yl]amino}ethyl]-7-(pyridin-2-ylmethoxy)-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[4-(4-methylthiophen-3-yl)pyridin-2-yl]amino}ethyl]-7-(pyridin-2-ylmethoxy)-1,2-dihydroquinolin-2-one;   3-[(1 S)-1-{[4-(1-benzyl-1H-imidazol-5-yl)pyridin-2-yl]amino}ethyl]-6-chloro-7-(pyridin-2-ylmethoxy)-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[4-(1-methyl-1H-imidazol-5-yl)pyridin-2-yl]amino}ethyl]-7-(pyridin-2-ylmethoxy)-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[4-(3-methylpyridin-4-yl)pyridin-2-yl]amino}ethyl]-7-(pyridin-2-ylmethoxy)-1,2-dihydroquinolin-2-one;   N-(2-{[(1 S)-1-[6-chloro-2-oxo-7-(pyridin-2-ylmethoxy)-1,2-dihydroquinolin-3-yl]ethyl]amino}pyridin-4-yl)-N-(2-methylpropyl)methanesulfonamide;   6-{[(1 S)-1-(6-chloro-7-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}-2-methylpyridine-3-carbonitrile;   methyl N-(2-{[(1 S)-1-(6-chloro-7-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}pyridin-4-yl)carbamate;   2-{[(1 S)-1-(6-chloro-7-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}pyridine-4-carboxamide;   6-chloro-3-[(1 S)-1-{[3-fluoro-4-(2-oxo-1,3-oxazolidin-3-yl)pyridin-2-yl]amino}ethyl]-7-methoxy-1,2-dihydroquinolin-2-one;   6-chloro-7-methoxy-3-[(1 S)-1-{[4-(5-methyl-1H-1,2,3,4-tetrazol-1-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   N-(2-{[(1 S)-1-(6-chloro-7-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}pyridin-4-yl)acetamide;   6-chloro-3-[(1 S)-1-{[4-(1H-imidazol-1-yl)pyridin-2-yl]amino}ethyl]-7-methoxy-1,2-dihydroquinolin-2-one;   6-chloro-7-methoxy-3-[(1 S)-1-{[4-(1,2-oxazol-4-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-7-methoxy-3-[(1 S)-1-{[4-(4-methylthiophen-3-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   3-[(1 S)-1-{[4-(1-benzyl-1H-imidazol-5-yl)pyridin-2-yl]amino}ethyl]-6-chloro-7-methoxy-1,2-dihydroquinolin-2-one;   6-chloro-7-methoxy-3-[(1 S)-1-{[4-(1-methyl-1H-imidazol-5-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-7-methoxy-3-[(1 S)-1-{[4-(3-methylpyridin-4-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   N-(2-{[(1 S)-1-(6-chloro-7-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}pyridin-4-yl)-N-(2-methylpropyl)methanesulfonamide;   6-{[(1 S)-1-[6-chloro-2-oxo-7-(propan-2-yloxy)-1,2-dihydroquinolin-3-yl]ethyl]amino}-2-methylpyridine-3-carbonitrile;   methyl N-(2-{[(1 S)-1-[6-chloro-2-oxo-7-(propan-2-yloxy)-1,2-dihydroquinolin-3-yl]ethyl]amino}pyridin-4-yl)carbamate;   2-{[(1 S)-1-[6-chloro-2-oxo-7-(propan-2-yloxy)-1,2-dihydroquinolin-3-yl]ethyl]amino}pyridine-4-carboxamide;   6-chloro-3-[(1 S)-1-{[3-fluoro-4-(2-oxo-1,3-oxazolidin-3-yl)pyridin-2-yl]amino}ethyl]-7-(propan-2-yloxy)-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[4-(5-methyl-1H-1,2,3,4-tetrazol-1-yl)pyridin-2-yl]amino}ethyl]-7-(propan-2-yloxy)-1,2-dihydroquinolin-2-one;   N-(2-{[(1S)-1-[6-chloro-2-oxo-7-(propan-2-yloxy)-1,2-dihydroquinolin-3-yl]ethyl]amino}pyridin-4-yl)acetamide;   6-chloro-3-[(1 S)-1-{[4-(1H-imidazol-1-yl)pyridin-2-yl]amino}ethyl]-7-(propan-2-yloxy)-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[4-(1,2-oxazol-4-yl)pyridin-2-yl]amino}ethyl]-7-(propan-2-yloxy)-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[4-(4-methylthiophen-3-yl)pyridin-2-yl]amino}ethyl]-7-(propan-2-yloxy)-1,2-dihydroquinolin-2-one;   3-[(1 S)-1-{[4-(1-benzyl-1H-imidazol-5-yl)pyridin-2-yl]amino}ethyl]-6-chloro-7-(propan-2-yloxy)-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[4-(1-methyl-1H-imidazol-5-yl)pyridin-2-yl]amino}ethyl]-7-(propan-2-yloxy)-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[4-(3-methylpyridin-4-yl)pyridin-2-yl]amino}ethyl]-7-(propan-2-yloxy)-1,2-dihydroquinolin-2-one;   N-(2-{[(1 S)-1-[6-chloro-2-oxo-7-(propan-2-yloxy)-1,2-dihydroquinolin-3-yl]ethyl]amino}pyridin-4-yl)-N-(2-methylpropyl)methanesulfonamide;   6-{[(1 S)-1-[6-chloro-7-(cyclopropylmethoxy)-2-oxo-1,2-dihydroquinolin-3-yl]ethyl]amino}-2-methylpyridine-3-carbonitrile;   methyl N-(2-{[(1 S)-1-[6-chloro-7-(cyclopropylmethoxy)-2-oxo-1,2-dihydroquinolin-3-yl]ethyl]amino}pyridin-4-yl)carbamate;   2-{[(1 S)-1-[6-chloro-7-(cyclopropylmethoxy)-2-oxo-1,2-dihydroquinolin-3-yl]ethyl]amino}pyridine-4-carboxamide;   6-chloro-7-(cyclopropylmethoxy)-3-[(1 S)-1-{[3-fluoro-4-(2-oxo-1,3-oxazolidin-3-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-7-(cyclopropylmethoxy)-3-[(1 S)-1-{[4-(5-methyl-1H-1,2,3,4-tetrazol-1-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   N-(2-{[(1S)-1-[6-chloro-7-(cyclopropylmethoxy)-2-oxo-1,2-dihydroquinolin-3-yl]ethyl]amino}pyridin-4-yl)acetamide;   6-chloro-7-(cyclopropylmethoxy)-3-[(1 S)-1-{[4-(1H-imidazol-1-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-7-(cyclopropylmethoxy)-3-[(1 S)-1-{[4-(1,2-oxazol-4-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-7-(cyclopropylmethoxy)-3-[(1 S)-1-{[4-(4-methylthiophen-3-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   3-[(1 S)-1-{[4-(1-benzyl-1H-imidazol-5-yl)pyridin-2-yl]amino}ethyl]-6-chloro-7-(cyclopropylmethoxy)-1,2-dihydroquinolin-2-one;   6-chloro-7-(cyclopropylmethoxy)-3-[(1 S)-1-{[4-(1-methyl-1H-imidazol-5-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-7-(cyclopropylmethoxy)-3-[(1 S)-1-{[4-(3-methylpyridin-4-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   N-(2-{[(1 S)-1-[6-chloro-7-(cyclopropylmethoxy)-2-oxo-1,2-dihydroquinolin-3-yl]ethyl]amino}pyridin-4-yl)-N-(2-methylpropyl)methanesulfonamide;   6-{[(1 S)-1-(6-chloro-7-fluoro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}-2-methylpyridine-3-carbonitrile;   methyl N-(2-{[(1 S)-1-(6-chloro-7-fluoro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}pyridin-4-yl)carbamate;   2-{[(1 S)-1-(6-chloro-7-fluoro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}pyridine-4-carboxamide;   6-chloro-7-fluoro-3-[(1 S)-1-{[3-fluoro-4-(2-oxo-1,3-oxazolidin-3-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-7-fluoro-3-[(1 S)-1-{[4-(5-methyl-1H-1,2,3,4-tetrazol-1-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   N-(2-{[(1 S)-1-(6-chloro-7-fluoro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}pyridin-4-yl)acetamide;   6-chloro-7-fluoro-3-[(1 S)-1-{[4-(1H-imidazol-1-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-7-fluoro-3-[(1 S)-1-{[4-(1,2-oxazol-4-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-7-fluoro-3-[(1 S)-1-{[4-(4-methylthiophen-3-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   3-[(1 S)-1-{[4-(1-benzyl-1H-imidazol-5-yl)pyridin-2-yl]amino}ethyl]-6-chloro-7-fluoro-1,2-dihydroquinolin-2-one;   6-chloro-7-fluoro-3-[(1 S)-1-{[4-(1-methyl-1H-imidazol-5-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-7-fluoro-3-[(1 S)-1-{[4-(3-methylpyridin-4-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   N-(2-{[(1 S)-1-(6-chloro-7-fluoro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}pyridin-4-yl)-N-(2-methylpropyl)methanesulfonamide;   6-{[(1 S)-1-(6-chloro-8-fluoro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}-2-methylpyridine-3-carbonitrile;   methyl N-(2-{[(1 S)-1-(6-chloro-8-fluoro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}pyridin-4-yl)carbamate;   2-{[(1 S)-1-(6-chloro-8-fluoro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}pyridine-4-carboxamide;   6-chloro-8-fluoro-3-[(1 S)-1-{[3-fluoro-4-(2-oxo-1,3-oxazolidin-3-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-8-fluoro-3-[(1 S)-1-{[4-(5-methyl-1H-1,2,3,4-tetrazol-1-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   N-(2-{[(1 S)-1-(6-chloro-8-fluoro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}pyridin-4-yl)acetamide;   6-chloro-8-fluoro-3-[(1 S)-1-{[4-(1H-imidazol-1-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-8-fluoro-3-[(1 S)-1-{[4-(1,2-oxazol-4-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-8-fluoro-3-[(1 S)-1-{[4-(4-methylthiophen-3-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   3-[(1 S)-1-{[4-(1-benzyl-1H-imidazol-5-yl)pyridin-2-yl]amino}ethyl]-6-chloro-8-fluoro-1,2-dihydroquinolin-2-one;   6-chloro-8-fluoro-3-[(1 S)-1-{[4-(1-methyl-1H-imidazol-5-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-8-fluoro-3-[(1 S)-1-{[4-(3-methylpyridin-4-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   N-(2-{[(1 S)-1-(6-chloro-8-fluoro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}pyridin-4-yl)-N-(2-methylpropyl)methanesulfonamide;   6-{[(1 S)-1-(6-chloro-2-oxo-1,2-dihydro-1,8-naphthyridin-3-yl)ethyl]amino}-2-methylpyridine-3-carbonitrile;   methyl N-(2-{[(1 S)-1-(6-chloro-2-oxo-1,2-dihydro-1,8-naphthyridin-3-yl)ethyl]amino}pyridin-4-yl)carbamate;   2-{[(1 S)-1-(6-chloro-2-oxo-1,2-dihydro-1,8-naphthyridin-3-yl)ethyl]amino}pyridine-4-carboxamide;   6-chloro-3-[(1 S)-1-{[3-fluoro-4-(2-oxo-1,3-oxazolidin-3-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydro-1, 8-naphthyridin-2-one;   6-chloro-3-[(1 S)-1-{[4-(5-methyl-1H-1,2,3,4-tetrazol-1-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydro-1,8-naphthyridin-2-one;   N-(2-{[(1 S)-1-(6-chloro-2-oxo-1,2-dihydro-1,8-naphthyridin-3-yl)ethyl]amino}pyridin-4-yl)acetamide;   6-chloro-3-[(1 S)-1-{[4-(1H-imidazol-1-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydro-1,8-naphthyridin-2-one;   6-chloro-3-[(1 S)-1-{[4-(1,2-oxazol-4-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydro-1,8-naphthyridin-2-one;   6-chloro-3-[(1 S)-1-{[4-(4-methylthiophen-3-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydro-1,8-naphthyridin-2-one;   3-[(1 S)-1-{[4-(1-benzyl-1H-imidazol-5-yl)pyridin-2-yl]amino}ethyl]-6-chloro-1,2-dihydro-1,8-naphthyridin-2-one;   6-chloro-3-[(1 S)-1-{[4-(1-methyl-1H-imidazol-5-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydro-1,8-naphthyridin-2-one;   6-chloro-3-[(1 S)-1-{[4-(3-methylpyridin-4-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydro-1,8-naphthyridin-2-one;   N-(2-{[(1 S)-1-(6-chloro-2-oxo-1,2-dihydro-1,8-naphthyridin-3-yl)ethyl]amino}pyridin-4-yl)-N-(2-methylpropyl)methanesulfonamide;   6-{[(1 S)-1-(7-chloro-3-oxo-3,4-dihydroquinoxalin-2-yl)ethyl]amino}-2-methylpyridine-3-carbonitrile;   methyl N-(2-{[(1 S)-1-(7-chloro-3-oxo-3,4-dihydroquinoxalin-2-yl)ethyl]amino}pyridin-4-yl)carbamate;   6-chloro-3-[(1 S)-1-{[3-fluoro-4-(2-oxo-1,3-oxazolidin-3-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinoxalin-2-one;   6-chloro-3-[(1 S)-1-{[4-(5-methyl-1H-1,2,3,4-tetrazol-1-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinoxalin-2-one;   N-(2-{[(1 S)-1-(7-chloro-3-oxo-3,4-dihydroquinoxalin-2-yl)ethyl]amino}pyridin-4-yl)acetamide;   6-chloro-3-[(1S)-1-{[4-(1H-imidazol-1-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinoxalin-2-one;   6-chloro-3-[(1 S)-1-{[4-(1,2-oxazol-4-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinoxalin-2-one   6-chloro-3-[(1 S)-1-{[4-(4-methylthiophen-3-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinoxalin-2-one;   3-[(S)-1-{[4-(1-benzyl-1H-imidazol-5-yl)pyridin-2-yl]amino}ethyl]-6-chloro-1,2-dihydroquinoxalin-2-one;   6-chloro-3-[(1 S)-1-{[4-(1-methyl-1H-imidazol-5-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinoxalin-2-one;   6-chloro-3-[(1 S)-1-{[4-(3-methylpyridin-4-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinoxalin-2-one;   N-(2-{[(1 S)-1-(7-chloro-3-oxo-3,4-dihydroquinoxalin-2-yl)ethyl]amino}pyridin-4-yl)-N-(2-methylpropyl)methanesulfonamide; and   (S)-6-chloro-3-(1-((4-(5-methyl-1H-tetrazol-1-yl)pyridin-2-yl)amino)ethyl)-1,8-naphthyridin-2(1H)-one;   or a pharmaceutically acceptable salt thereof.   
     
     
         44 . The method of  claim 43 , wherein the cell-proliferative disease is glioma, glioblastoma multiforme, paraganglioma, acute myeloid leukemia (AML), prostate cancer, thyroid cancer, colon cancer, chondrosarcoma, cholangiocarcinoma, peripheral T-cell lymphoma, melanoma, intrahepatic cholangiocarcinoma (IHCC), myelodysplastic syndrome (MDS), or myeloproliferative disease (MPD). 
     
     
         45 . The method of  claim 44 , wherein the cell-proliferative disease is glioma, glioblastoma multiforme (GBM), acute myeloid leukemia (AML), chondrosarcoma, intrahepatic cholangiocarcinoma (IHCC), myelodysplastic syndrome (MDS) or myeloproliferative disease (MPD). 
     
     
         46 . A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound selected from the group consisting of:
 6-{[(1 S)-1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}-4-methoxypyridine-3-carbonitrile;   6-{[(1 S)-1-(6-chloro-1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}-4-methoxypyridine-3-carbonitrile;   6-{[(1R)-1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}-4-methoxypyridine-3-carbonitrile;   6-{[(1 S)-1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}-2-methylpyridine-3-carbonitrile;   6-{[(1 S)-1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}-4-methylpyridine-3-carbonitrile;   6-{[(1 S)-1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}-2-methoxypyridine-3-carbonitrile;   5-{[(1 S)-1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}-6-methoxypyridine-2-carbonitrile;   6-{[(1R)-1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}-2-methylpyridine-3-carbonitrile;   6-{[1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}-2-methylpyridine-3-carbonitrile;   6-chloro-3-[(1 S)-1-{[4-(2-oxo-1,3-oxazolidin-3-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[6-(2-oxo-1,3-oxazolidin-3-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[6-methyl-4-(2-oxo-1,3-oxazolidin-3-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[4-(4,4-dimethyl-2-oxo-1,3-oxazolidin-3-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[3-fluoro-4-(2-oxo-1,3-oxazolidin-3-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[3-methyl-4-(2-oxo-1,3-oxazolidin-3-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[4-fluoro-6-(2-oxo-1,3-oxazolidin-3-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[6-fluoro-4-(2-oxo-1,3-oxazolidin-3-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-3-[1-({4-[(4S)-2-oxo-4-(propan-2-yl)-1,3-oxazolidin-3-yl]pyridin-2-yl}amino)ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-({6-[(4S)-2-oxo-4-(propan-2-yl)-1,3-oxazolidin-3-yl]pyridin-2-yl}amino)ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1R)-1-({6-[(4S)-2-oxo-4-(propan-2-yl)-1,3-oxazolidin-3-yl]pyridin-2-yl}amino)ethyl]-1,2-dihydroquinolin-2-one;   6-{[1-(6-chloro-7-fluoro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}-2-methylpyridine-3-carbonitrile;   6-{[(1 S)-1-(6-chloro-7-fluoro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}-2-methylpyridine-3-carbonitrile;   6-{[(1 S)-1-(6-chloro-7-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}-2-methylpyridine-3-carbonitrile;   6-{[1-(6-chloro-7-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}-2-methylpyridine-3-carbonitrile;   6-{[(1 S)-1-(6-chloro-7-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}-4-methoxypyridine-3-carbonitrile;   6-{[(1 S)-1-(6-chloro-7-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}-2-methoxypyridine-3-carbonitrile;   6-{[(1 S)-1-(6-chloro-7-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}-4-methylpyridine-3-carbonitrile;   6-{[(1 S)-1-[6-chloro-2-oxo-7-(pyridin-2-ylmethoxy)-1,2-dihydroquinolin-3-yl]ethyl]amino}-2-methylpyridine-3-carbonitrile;   6-({1-[6-chloro-2-oxo-7-(pyridin-2-ylmethoxy)-1,2-dihydroquinolin-3-yl]ethyl}amino)-2-methylpyridine-3-carbonitrile;   6-[(1-{6-chloro-7-[(3,3-difluorocyclobutyl)methoxy]-2-oxo-1,2-dihydroquinolin-3-yl}ethyl)amino]-2-methylpyridine-3-carbonitrile;   6-{[1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)cyclopropyl]amino}-2-methylpyridine-3-carbonitrile;   6-{[2-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)propan-2-yl]amino}-2-methylpyridine-3-carbonitrile;   6-chloro-3-[(1 S)-1-({4-[(2-hydroxyethyl)amino]-6-methylpyridin-2-yl}amino)ethyl]-1,2-dihydroquinolin-2-one;   N-(2-{[(1 S)-1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}-3-fluoropyridin-4-yl)acetamide;   2-(6-{[(1 S)-1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}pyridin-2-yl)-1λ 6 ,2-thiazolidine-1,1-dione;   6-chloro-3-[(1 S)-1-({3-fluoro-4-[(2-hydroxyethyl)amino]pyridin-2-yl}amino)ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[3-fluoro-4-(1H-imidazol-1-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[3-fluoro-4-(4-methyl-1H-imidazol-1-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[4-(1,3-dimethyl-1H-pyrazol-5-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[4-(1,5-dimethyl-1H-pyrazol-4-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[4-(1H-pyrazol-5-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[3-fluoro-4-(1-methyl-1H-pyrrol-2-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-({4-[1-(2-methylpropyl)-1H-pyrazol-5-yl]pyridin-2-yl}amino)ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-({4-[1-(propan-2-yl)-1H-pyrazol-5-yl]pyridin-2-yl}amino)ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[4-(1,5-dimethyl-1H-pyrazol-4-yl)-3-fluoropyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[3-fluoro-4-(4-methylthiophen-3-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-({4-[1-(oxan-2-yl)-1H-pyrazol-5-yl]pyridin-2-yl}amino)ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[4-(4-methylthiophen-3-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[4-(1-methyl-1H-pyrazol-5-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-({4-[3-(trifluoromethyl)-1H-pyrazol-4-yl]pyridin-2-yl}amino)ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[4-(3,5-dimethyl-1H-pyrazol-4-yl)-3-fluoropyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[4-(1,3-dimethyl-1H-pyrazol-5-yl)-3-fluoropyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[3-fluoro-4-(1-methyl-1H-pyrazol-5-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[4-(dimethyl-1,2-oxazol-4-yl)-3-fluoropyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-({3-fluoro-4-[1-(oxan-2-yl)-1H-pyrazol-5-yl]pyridin-2-yl}amino)ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-({3-fluoro-4-[1-(2-methylpropyl)-1H-pyrazol-5-yl]pyridin-2-yl}amino)ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-({3-fluoro-4-[1-(propan-2-yl)-1H-pyrazol-5-yl]pyridin-2-yl}amino)ethyl]-1,2-dihydroquinolin-2-one;   6-{[(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)methyl]amino}-2-methylpyridine-3-carbonitrile;   6-{[(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)methyl]amino}-4-methylpyridine-3-carbonitrile;   6-{[(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)methyl]amino}-2-(trifluoromethyl)pyridine-3-carbonitrile;   5-{[(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)methyl]amino}-6-methoxypyridine-2-carbonitrile;   2-chloro-6-{[(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)methyl]amino}pyridine-3-carbonitrile;   6-{[(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)methyl]amino}-2-(2-oxo-1,3-oxazolidin-3-yl)pyridine-3-carbonitrile;   6-{[(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)methyl]amino}-2-[2-(propan-2-yl)pyrrolidin-1-yl]pyridine-3-carbonitrile;   6-{[(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)methyl]amino}-2-[methyl(2-methylpropyl)amino]pyridine-3-carbonitrile;   6-{[(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)methyl]amino}-2-methoxypyridine-3-carbonitrile;   6-{[(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)methyl]amino}pyridine-3-carbonitrile;   6-chloro-3-({[3-(propan-2-yl)pyridin-2-yl]amino}methyl)-1,2-dihydroquinolin-2-one;   6-chloro-3-{[(4,6-dimethylpyridin-2-yl)amino]methyl}-1,2-dihydroquinolin-2-one;   6-chloro-3-{[(4-methoxypyridin-2-yl)amino]methyl}-1,2-dihydroquinolin-2-one;   6-chloro-3-{[(5-fluoropyridin-2-yl)amino]methyl}-1,2-dihydroquinolin-2-one;   2-{[(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)methyl]amino}pyridine-4-carbonitrile;   methyl 6-{[(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)methyl]amino}pyridine-2-carboxylate;   6-chloro-3-{[(4-methylpyridin-2-yl)amino]methyl}-1,2-dihydroquinolin-2-one;   6-chloro-3-{[(5-chloropyridin-2-yl)amino]methyl}-1,2-dihydroquinolin-2-one;   6-chloro-3-{[(2-hydroxypyridin-3-yl)amino]methyl}-1,2-dihydroquinolin-2-one;   6-chloro-3-({[5-(trifluoromethyl)pyridin-2-yl]amino}methyl)-1,2-dihydroquinolin-2-one;   5-{[(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)methyl]amino}pyridine-2-carbonitrile;   6-chloro-3-({[4-(trifluoromethyl)pyridin-2-yl]amino}methyl)-1,2-dihydroquinolin-2-one;   6-{[(6,7-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]amino}pyridine-3-carbonitrile;   6-{[(6-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)methyl]amino}pyridine-3-carbonitrile;   6-methoxy-3-{[(4-methylpyridin-2-yl)amino]methyl}-1,2-dihydroquinolin-2-one;   6-{[(6-chloro-7-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)methyl]amino}-2-methylpyridine-3-carbonitrile;   6-({[6-chloro-2-oxo-7-(pyridin-2-ylmethoxy)-1,2-dihydroquinolin-3-yl]methyl}amino)-2-methylpyridine-3-carbonitrile;   6-[({6-chloro-7-[2-(4-methanesulfonylpiperazin-1-yl)ethoxy]-2-oxo-1,2-dihydroquinolin-3-yl}methyl)amino]-2-methylpyridine-3-carbonitrile;   Methyl N-(2-{[(1 S)-1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}pyridin-4-yl)carbamate;   2-{[(1 S)-1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}pyridine-4-carboxamide;   6-chloro-3-[(1 S)-1-{[4-(5-methyl-1H-1,2,3,4-tetrazol-1-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   N-(2-{[(1 S)-1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}pyridin-4-yl)acetamide;   6-chloro-3-[(1 S)-1-{[4-(1H-imidazol-1-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[4-(1,2-oxazol-4-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   3-[(1 S)-1-{[4-(1-benzyl-1H-imidazol-5-yl)pyridin-2-yl]amino}ethyl]-6-chloro-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[4-(1-methyl-1H-imidazol-5-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[4-(3-methylpyridin-4-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   N-(2-{[(1 S)-1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}pyridin-4-yl)-N-(2-methylpropyl)methanesulfonamide;   methyl N-(2-{[(1 S)-1-[6-chloro-2-oxo-7-(pyridin-2-ylmethoxy)-1,2-dihydroquinolin-3-yl]ethyl]amino}pyridin-4-yl)carbamate;   2-{[(1 S)-1-[6-chloro-2-oxo-7-(pyridin-2-ylmethoxy)-1,2-dihydroquinolin-3-yl]ethyl]amino}pyridine-4-carboxamide;   6-chloro-3-[(1 S)-1-{[3-fluoro-4-(2-oxo-1,3-oxazolidin-3-yl)pyridin-2-yl]amino}ethyl]-7-(pyridin-2-ylmethoxy)-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[4-(5-methyl-1H-1,2,3,4-tetrazol-1-yl)pyridin-2-yl]amino}ethyl]-7-(pyridin-2-ylmethoxy)-1,2-dihydroquinolin-2-one;   N-(2-{[(1 S)-1-[6-chloro-2-oxo-7-(pyridin-2-ylmethoxy)-1,2-dihydroquinolin-3-yl]ethyl]amino}pyridin-4-yl)acetamide;   6-chloro-3-[(1 S)-1-{[4-(1H-imidazol-1-yl)pyridin-2-yl]amino}ethyl]-7-(pyridin-2-ylmethoxy)-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[4-(1,2-oxazol-4-yl)pyridin-2-yl]amino}ethyl]-7-(pyridin-2-ylmethoxy)-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[4-(4-methylthiophen-3-yl)pyridin-2-yl]amino}ethyl]-7-(pyridin-2-ylmethoxy)-1,2-dihydroquinolin-2-one;   3-[(1 S)-1-{[4-(1-benzyl-1H-imidazol-5-yl)pyridin-2-yl]amino}ethyl]-6-chloro-7-(pyridin-2-ylmethoxy)-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[4-(1-methyl-1H-imidazol-5-yl)pyridin-2-yl]amino}ethyl]-7-(pyridin-2-ylmethoxy)-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[4-(3-methylpyridin-4-yl)pyridin-2-yl]amino}ethyl]-7-(pyridin-2-ylmethoxy)-1,2-dihydroquinolin-2-one;   N-(2-{[(1 S)-1-[6-chloro-2-oxo-7-(pyridin-2-ylmethoxy)-1,2-dihydroquinolin-3-yl]ethyl]amino}pyridin-4-yl)-N-(2-methylpropyl)methanesulfonamide;   6-{[(1 S)-1-(6-chloro-7-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}-2-methylpyridine-3-carbonitrile;   methyl N-(2-{[(1 S)-1-(6-chloro-7-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}pyridin-4-yl)carbamate;   2-{[(1 S)-1-(6-chloro-7-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}pyridine-4-carboxamide;   6-chloro-3-[(1 S)-1-{[3-fluoro-4-(2-oxo-1,3-oxazolidin-3-yl)pyridin-2-yl]amino}ethyl]-7-methoxy-1,2-dihydroquinolin-2-one;   6-chloro-7-methoxy-3-[(1 S)-1-{[4-(5-methyl-1H-1,2,3,4-tetrazol-1-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   N-(2-{[(1 S)-1-(6-chloro-7-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}pyridin-4-yl)acetamide;   6-chloro-3-[(1 S)-1-{[4-(1H-imidazol-1-yl)pyridin-2-yl]amino}ethyl]-7-methoxy-1,2-dihydroquinolin-2-one;   6-chloro-7-methoxy-3-[(1 S)-1-{[4-(1,2-oxazol-4-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-7-methoxy-3-[(1 S)-1-{[4-(4-methylthiophen-3-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   3-[(1 S)-1-{[4-(1-benzyl-1H-imidazol-5-yl)pyridin-2-yl]amino}ethyl]-6-chloro-7-methoxy-1,2-dihydroquinolin-2-one;   6-chloro-7-methoxy-3-[(1 S)-1-{[4-(1-methyl-1H-imidazol-5-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-7-methoxy-3-[(1 S)-1-{[4-(3-methylpyridin-4-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   N-(2-{[(1 S)-1-(6-chloro-7-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}pyridin-4-yl)-N-(2-methylpropyl)methanesulfonamide;   6-{[(1 S)-1-[6-chloro-2-oxo-7-(propan-2-yloxy)-1,2-dihydroquinolin-3-yl]ethyl]amino}-2-methylpyridine-3-carbonitrile;   methyl N-(2-{[(1 S)-1-[6-chloro-2-oxo-7-(propan-2-yloxy)-1,2-dihydroquinolin-3-yl]ethyl]amino}pyridin-4-yl)carbamate;   2-{[(1 S)-1-[6-chloro-2-oxo-7-(propan-2-yloxy)-1,2-dihydroquinolin-3-yl]ethyl]amino}pyridine-4-carboxamide;   6-chloro-3-[(1S)-1-{[3-fluoro-4-(2-oxo-1,3-oxazolidin-3-yl)pyridin-2-yl]amino}ethyl]-7-(propan-2-yloxy)-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[4-(5-methyl-1H-1,2,3,4-tetrazol-1-yl)pyridin-2-yl]amino}ethyl]-7-(propan-2-yloxy)-1,2-dihydroquinolin-2-one;   N-(2-{[(1 S)-1-[6-chloro-2-oxo-7-(propan-2-yloxy)-1,2-dihydroquinolin-3-yl]ethyl]amino}pyridin-4-yl)acetamide;   6-chloro-3-[(1 S)-1-{[4-(1H-imidazol-1-yl)pyridin-2-yl]amino}ethyl]-7-(propan-2-yloxy)-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[4-(1,2-oxazol-4-yl)pyridin-2-yl]amino}ethyl]-7-(propan-2-yloxy)-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[4-(4-methylthiophen-3-yl)pyridin-2-yl]amino}ethyl]-7-(propan-2-yloxy)-1,2-dihydroquinolin-2-one;   3-[(1 S)-1-{[4-(1-benzyl-1H-imidazol-5-yl)pyridin-2-yl]amino}ethyl]-6-chloro-7-(propan-2-yloxy)-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[4-(i-methyl-1H-imidazol-5-yl)pyridin-2-yl]amino}ethyl]-7-(propan-2-yloxy)-1,2-dihydroquinolin-2-one;   6-chloro-3-[(1 S)-1-{[4-(3-methylpyridin-4-yl)pyridin-2-yl]amino}ethyl]-7-(propan-2-yloxy)-1,2-dihydroquinolin-2-one;   N-(2-{[(1 S)-1-[6-chloro-2-oxo-7-(propan-2-yloxy)-1,2-dihydroquinolin-3-yl]ethyl]amino}pyridin-4-yl)-N-(2-methylpropyl)methanesulfonamide;   6-{[(1 S)-1-[6-chloro-7-(cyclopropylmethoxy)-2-oxo-1,2-dihydroquinolin-3-yl]ethyl]amino}-2-methylpyridine-3-carbonitrile;   methyl N-(2-{[(1 S)-1-[6-chloro-7-(cyclopropylmethoxy)-2-oxo-1,2-dihydroquinolin-3-yl]ethyl]amino}pyridin-4-yl)carbamate;   2-{[(1 S)-1-[6-chloro-7-(cyclopropylmethoxy)-2-oxo-1,2-dihydroquinolin-3-yl]ethyl]amino}pyridine-4-carboxamide;   6-chloro-7-(cyclopropylmethoxy)-3-[(1 S)-1-{[3-fluoro-4-(2-oxo-1,3-oxazolidin-3-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-7-(cyclopropylmethoxy)-3-[(1 S)-1-{[4-(5-methyl-1H-1,2,3,4-tetrazol-1-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   N-(2-{[(1 S)-1-[6-chloro-7-(cyclopropylmethoxy)-2-oxo-1,2-dihydroquinolin-3-yl]ethyl]amino}pyridin-4-yl)acetamide;   6-chloro-7-(cyclopropylmethoxy)-3-[(1 S)-1-{[4-(1H-imidazol-1-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-7-(cyclopropylmethoxy)-3-[(1 S)-1-{[4-(1,2-oxazol-4-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-7-(cyclopropylmethoxy)-3-[(1 S)-1-{[4-(4-methylthiophen-3-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   3-[(1 S)-1-{[4-(1-benzyl-1H-imidazol-5-yl)pyridin-2-yl]amino}ethyl]-6-chloro-7-(cyclopropylmethoxy)-1,2-dihydroquinolin-2-one;   6-chloro-7-(cyclopropylmethoxy)-3-[(1 S)-1-{[4-(1-methyl-1H-imidazol-5-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-7-(cyclopropylmethoxy)-3-[(1 S)-1-{[4-(3-methylpyridin-4-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   N-(2-{[(1 S)-1-[6-chloro-7-(cyclopropylmethoxy)-2-oxo-1,2-dihydroquinolin-3-yl]ethyl]amino}pyridin-4-yl)-N-(2-methylpropyl)methanesulfonamide;   6-{[(1 S)-1-(6-chloro-7-fluoro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}-2-methylpyridine-3-carbonitrile;   methyl N-(2-{[(1 S)-1-(6-chloro-7-fluoro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}pyridin-4-yl)carbamate;   2-{[(1 S)-1-(6-chloro-7-fluoro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}pyridine-4-carboxamide;   6-chloro-7-fluoro-3-[(1 S)-1-{[3-fluoro-4-(2-oxo-1,3-oxazolidin-3-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-7-fluoro-3-[(1 S)-1-{[4-(5-methyl-1H-1,2,3,4-tetrazol-1-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   N-(2-{[(1 S)-1-(6-chloro-7-fluoro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}pyridin-4-yl)acetamide;   6-chloro-7-fluoro-3-[(1 S)-1-{[4-(1H-imidazol-1-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-7-fluoro-3-[(1 S)-1-{[4-(1,2-oxazol-4-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-7-fluoro-3-[(1 S)-1-{[4-(4-methylthiophen-3-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   3-[(1 S)-1-{[4-(1-benzyl-1H-imidazol-5-yl)pyridin-2-yl]amino}ethyl]-6-chloro-7-fluoro-1,2-dihydroquinolin-2-one;   6-chloro-7-fluoro-3-[(1 S)-1-{[4-(1-methyl-1H-imidazol-5-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-7-fluoro-3-[(1 S)-1-{[4-(3-methylpyridin-4-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   N-(2-{[(1 S)-1-(6-chloro-7-fluoro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}pyridin-4-yl)-N-(2-methylpropyl)methanesulfonamide;   6-{[(1 S)-1-(6-chloro-8-fluoro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}-2-methylpyridine-3-carbonitrile;   methyl N-(2-{[(1 S)-1-(6-chloro-8-fluoro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}pyridin-4-yl)carbamate;   2-{[(1 S)-1-(6-chloro-8-fluoro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}pyridine-4-carboxamide;   6-chloro-8-fluoro-3-[(1 S)-1-{[3-fluoro-4-(2-oxo-1,3-oxazolidin-3-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-8-fluoro-3-[(1 S)-1-{[4-(5-methyl-1H-1,2,3,4-tetrazol-1-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   N-(2-{[(1 S)-1-(6-chloro-8-fluoro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}pyridin-4-yl)acetamide;   6-chloro-8-fluoro-3-[(1 S)-1-{[4-(1H-imidazol-1-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-8-fluoro-3-[(1 S)-1-{[4-(1,2-oxazol-4-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-8-fluoro-3-[(1 S)-1-{[4-(4-methylthiophen-3-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   3-[(1 S)-1-{[4-(1-benzyl-1H-imidazol-5-yl)pyridin-2-yl]amino}ethyl]-6-chloro-8-fluoro-1,2-dihydroquinolin-2-one;   6-chloro-8-fluoro-3-[(1 S)-1-{[4-(1-methyl-1H-imidazol-5-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   6-chloro-8-fluoro-3-[(1 S)-1-{[4-(3-methylpyridin-4-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one;   N-(2-{[(1 S)-1-(6-chloro-8-fluoro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino}pyridin-4-yl)-N-(2-methylpropyl)methanesulfonamide;   6-{[(1 S)-1-(6-chloro-2-oxo-1,2-dihydro-1,8-naphthyridin-3-yl)ethyl]amino}-2-methylpyridine-3-carbonitrile;   methyl N-(2-{[(1 S)-1-(6-chloro-2-oxo-1,2-dihydro-1,8-naphthyridin-3-yl)ethyl]amino}pyridin-4-yl)carbamate;   2-{[(1 S)-1-(6-chloro-2-oxo-1,2-dihydro-1,8-naphthyridin-3-yl)ethyl]amino}pyridine-4-carboxamide;   6-chloro-3-[(1 S)-1-{[3-fluoro-4-(2-oxo-1,3-oxazolidin-3-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydro-1,8-naphthyridin-2-one;   6-chloro-3-[(1 S)-1-{[4-(5-methyl-1H-1,2,3,4-tetrazol-1-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydro-1,8-naphthyridin-2-one;   N-(2-{[(1 S)-1-(6-chloro-2-oxo-1,2-dihydro-1,8-naphthyridin-3-yl)ethyl]amino}pyridin-4-yl)acetamide;   6-chloro-3-[(1 S)-1-{[4-(1H-imidazol-1-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydro-1,8-naphthyridin-2-one;   6-chloro-3-[(1 S)-1-{[4-(1,2-oxazol-4-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydro-1,8-naphthyridin-2-one;   6-chloro-3-[(1 S)-1-{[4-(4-methylthiophen-3-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydro-1,8-naphthyridin-2-one;   3-[(1 S)-1-{[4-(1-benzyl-1H-imidazol-5-yl)pyridin-2-yl]amino}ethyl]-6-chloro-1,2-dihydro-1,8-naphthyridin-2-one;   6-chloro-3-[(1 S)-1-{[4-(1-methyl-1H-imidazol-5-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydro-1,8-naphthyridin-2-one;   6-chloro-3-[(1 S)-1-{[4-(3-methylpyridin-4-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydro-1,8-naphthyridin-2-one;   N-(2-{[(1 S)-1-(6-chloro-2-oxo-1,2-dihydro-1,8-naphthyridin-3-yl)ethyl]amino}pyridin-4-yl)-N-(2-methylpropyl)methanesulfonamide;   6-{[(1 S)-1-(7-chloro-3-oxo-3,4-dihydroquinoxalin-2-yl)ethyl]amino}-2-methylpyridine-3-carbonitrile;   methyl N-(2-{[(1 S)-1-(7-chloro-3-oxo-3,4-dihydroquinoxalin-2-yl)ethyl]amino}pyridin-4-yl)carbamate;   6-chloro-3-[(1 S)-1-{[3-fluoro-4-(2-oxo-1,3-oxazolidin-3-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinoxalin-2-one;   6-chloro-3-[(1 S)-1-{[4-(5-methyl-1H-1,2,3,4-tetrazol-1-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinoxalin-2-one;   N-(2-{[(1 S)-1-(7-chloro-3-oxo-3,4-dihydroquinoxalin-2-yl)ethyl]amino}pyridin-4-yl)acetamide;   6-chloro-3-[(1 S)-1-{[4-(1H-imidazol-1-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinoxalin-2-one;   6-chloro-3-[(1 S)-1-{[4-(1,2-oxazol-4-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinoxalin-2-one   6-chloro-3-[(1 S)-1-{[4-(4-methylthiophen-3-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinoxalin-2-one;   3-[(1 S)-1-{[4-(1-benzyl-1H-imidazol-5-yl)pyridin-2-yl]amino}ethyl]-6-chloro-1,2-dihydroquinoxalin-2-one;   6-chloro-3-[(1 S)-1-{[4-(1-methyl-1H-imidazol-5-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinoxalin-2-one;   6-chloro-3-[(1 S)-1-{[4-(3-methylpyridin-4-yl)pyridin-2-yl]amino}ethyl]-1,2-dihydroquinoxalin-2-one;   N-(2-{[(1 S)-1-(7-chloro-3-oxo-3,4-dihydroquinoxalin-2-yl)ethyl]amino}pyridin-4-yl)-N-(2-methylpropyl)methanesulfonamide; and   (S)-6-chloro-3-(1-((4-(5-methyl-1H-tetrazol-1-yl)pyridin-2-yl)amino)ethyl)-1,8-naphthyridin-2(1H)-one;   or a pharmaceutically acceptable salt thereof.
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