Method for producng tricyclic compound, and tricyclic compound capable of being produced by said production method

Abstract

An object of the present invention is to provide a method for reproducibly producing a pyrrolopyrimidine ring-containing tricyclic compound in high yield with reduced formation of by-products, and to provide a novel tricyclic compound capable of being obtained by this production method. The present invention provides a method for producing a compound represented by Formula (1) or a salt thereof, the method comprising the steps of: (I) causing an organic borane reagent to act on a compound represented by Formula (2) or a salt thereof, and (II) performing an intramolecular cyclization reaction of the reaction product of step (I) above using a zerovalent palladium catalyst in the presence of an alkali metal hydroxide.

1 . A compound represented by Formula (1′) 
       
         
           
           
               
               
           
         
         or a salt thereof, 
         wherein m is an integer of 0 to 2; 
         n is an integer of 0 or more and such that 0≤m+n≤3; 
         R 3  is amino which may be substituted; 
         one of R 6  or R 6 ′ is amino or C 1-6  alkylamino protected by alkyloxycarbonyl which may be substituted; and 
         the other one of R 6  or R 6 ′ is hydrogen. 
       
     
     
         2 . The compound or a salt thereof according to  claim 1 , wherein
 m and n is such that (m, n)=(0, 1), (1, 1), (0, 2), (2, 1), or (1, 2);   R 3  is amino;   one of R 6  or R 6 ′ is amino or C 1-6  alkylamino protected by alkyloxycarbonyl which may be substituted; and   the other one of R 6  or R 6 ′ is hydrogen.   
     
     
         3 . The compound or a salt thereof according to  claim 1 , wherein
 m and n is such that (m, n)=(0, 1), (1, 1), or (0, 2);   R 3  is amino;   one of R 6  or R 6 ′ is amino or C 1-4  alkylamino protected by tert-butoxycarbonyl;   and the other one of R 6  or R 6 ′ is hydrogen.