Compositions and uses thereof

Abstract

Provided are solid dispersions, solid molecular complexes, salts and crystalline polymorphs involving propane-1-sulfonic acid {3-[5-(4-chloro-phenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide.

1 .- 35 . (canceled) 
     
     
         36 . A crystalline polymorph Form 1 of Compound I that exhibits a powder x-ray diffraction pattern having characteristic peak locations of approximately 4.7, 9.4, 11.0, 12.5, and 15.4 degrees 2θ. 
     
     
         37 . A crystalline polymorph according to  claim 36 , wherein said polymorph exhibits a powder x-ray diffraction pattern having characteristic peak locations of approximately 4.7, 9.4, 10.0, 11.0, 12.5, 14.2, 15.4, 18.6, and 22.2 degrees 2θ. 
     
     
         38 . A crystalline polymorph according to  claim 36 , wherein said polymorph exhibits a powder x-ray diffraction pattern having characteristic peak locations of approximately 4.7, 9.4, 10.0, 11.0, 12.5, 14.2, 15.4, 16.1, 18.6, 19.0, 22.2 and 26.8 degrees 2θ. 
     
     
         39 . A crystalline polymorph according to  claim 36 , wherein said polymorph exhibits a powder x-ray diffraction pattern substantially the same as the powder x-ray diffraction pattern of  FIG. 1 . 
     
     
         40 . A method according to claim  23 , wherein Compound I is a crystalline polymorph that exhibits a powder x-ray diffraction pattern having characteristic peak locations of approximately 4.7, 9.4, 11.0, 12.5, and 15.4 degrees 2θ. 
     
     
         41 . A purified form of the crystalline polymorph of  claim 36 . 
     
     
         42 . A crystalline polymorph Form 2 of Compound I that exhibits a powder x-ray diffraction pattern having characteristic peak locations of approximately 8.8, 9.2, 13.5, 19.1 and 24.4 degrees 2θ. 
     
     
         43 . A crystalline polymorph according to  claim 42 , wherein said polymorph exhibits a powder x-ray diffraction pattern having characteristic peak locations of approximately 6.7, 8.8, 9.2, 13.5, 15.0, 17.7, 19.1, 19.7, 21.4 and 24.4 degrees 2θ. 
     
     
         44 . A crystalline polymorph according to  claim 42 , wherein said polymorph exhibits a powder x-ray diffraction pattern having characteristic peak locations of approximately 6.7, 8.8, 9.2, 13.5, 14.1, 14.5, 15.0, 16.2, 17.0, 17.7, 19.1, 19.7, 21.4, 22.2, 24.1, 24.4, and 28.1 degrees 2θ. 
     
     
         45 . A crystalline polymorph according to  claim 42 , wherein said polymorph exhibits a powder x-ray diffraction pattern substantially the same as the powder x-ray diffraction pattern of  FIG. 2 . 
     
     
         46 . A method according to claim  23 , wherein Compound I is a crystalline polymorph that exhibits a powder x-ray diffraction pattern having characteristic peak locations of approximately 8.8, 9.2, 13.5, 19.1 and 24.4 degrees 2θ. 
     
     
         47 .- 53 . (canceled)