Methods for treating relaxed hair

Abstract

Methods and kits for treating hair or preventing damage in the relaxing of hair are disclosed herein. Hair that is damaged during a relaxing treatment with hydroxide-containing relaxing agents, can be treated with formulations containing one or more active agents. The active agent formulations can be applied simultaneously with the hair relaxing formulation, or optionally applied immediately following application of the relaxing formulation, to reduce damage and breakage. Use of the active agent formulation along with a relaxing treatment can be used to control the level of curl achieved or retained in the relaxed hair, as compared to the natural amount of curl in the untreated hair.

1 - 30 . (canceled) 
     
     
         31 . A kit comprising:
 (a) a first formulation comprising one or more relaxing agents and having an alkaline pH, and   (b) a second formulation comprising an active agent, wherein the active agent has the following structure:   
       
         
           
           
               
               
           
         
       
       wherein Z is a linker or is absent and the linker is not a polymer; 
       m and n are each an integer independently selected from 1-6, and the sum of m+n is equal to or greater than 2;
 wherein A and B are covalently bonded to Z when Z is present; 
 B is a functional group capable of forming a covalent bond with a nucleophile, and B is independently selected from the group consisting of: 
 
       
         
           
           
               
               
           
         
       
       wherein R is independently selected from the group consisting of hydrogen, C 1-6  alkyl groups, aryl groups, or an ionizable functional groups and Z′ is oxygen (O), NH or is absent, and G is carbon (C) and g is 1, or G is sulfur (S) and g is 2;
 A is an ionizable functional group independently selected from the group consisting of: —COOH, —SO 3 H, —PO 3 H 2 , —N(R 1 ) 2 , —N(R 1 ) 3 ; wherein R 1  is independently selected from the group consisting of a hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocycloalkyl and heteroaryl groups; wherein each R 1  is independently unsubstituted or substituted with one or more substituents. 
 
     
     
         32 . The kit of  claim 31 , wherein the one or more relaxing agents are alkali metal containing hydroxides selected from the group consisting of sodium hydroxide, lithium hydroxide, and potassium hydroxide. 
     
     
         33 . The kit of  claim 31 , wherein the second formulation is in the form of a liquid. 
     
     
         34 . The kit of  claim 31 , wherein the second formulation is in the form of a cream. 
     
     
         35 . The kit of  claim 31 , wherein the second formulation is in the form of a lotion. 
     
     
         36 . The kit of  claim 31 , wherein the second formulation is in the form of a gel. 
     
     
         37 . The kit of  claim 31 , wherein the linker Z is an alkyl group, alkenyl group, cycloalkyl group, cycloalkenyl group, aryl group, heterocycloalkyl group, or heteroaryl group,
 wherein the alkyl, alkenyl, cycloalkyl, cycloalkenyl, aryl, heterocycloalkyl, or heteroaryl group, is unsubstituted or substituted one or more times by a halogen, cyano, alkoxy, alkyl, alkenyl, cycloalkyl, cycloalkenyl, aryl, heterocycloalkyl, heteroaryl, amine, hydroxy, oxo, formyl, acyl, carboxylic acid, —C(O)R 1 , —C(O)OR 1 , —COO − , primary amide, secondary amide, —C(O)NR 1 R 2 , —NR 1 R 2 , —NR 1 S(O) 2 R 2 , —NR 1 C(O)R 2 , —S(O) 2 R 2 , —SR 1 , —S(O) 2 NR 1 R 2 , —SOR 1 , or —SOOR 1 ;   wherein R 1  and R 2  are each independently selected from the group consisting of a hydrogen, alkyl group, alkenyl group, alkynyl group, cycloalkyl group, aryl group, heterocycloalkyl, and heteroaryl group, wherein each of R 1  and R 2  is independently unsubstituted or substituted with one or more substituents.   
     
     
         38 . The kit of  claim 31 , wherein the linker Z is a C 1-4  alkyl group. 
     
     
         39 . The kit of  claim 38 , wherein the alkyl group is substituted with one or more substituents replacing a hydrogen on one or more carbons of the alkyl hydrocarbon backbone or the alkyl group is substituted with one or more heteroatoms within the hydrocarbon carbon backbone, or a combination thereof, and
 wherein the substituents are selected from the group consisting of oxo, hydroxyl, carboxyl, amido, and amino groups.   
     
     
         40 . The kit of  claim 31 , wherein the active agent is selected from the group consisting of: 
       
         
           
           
               
               
           
         
         or simple salts thereof. 
       
     
     
         41 . The kit of  claim 31 , wherein the active agent is: 
       
         
           
           
               
               
           
         
       
       or a simple salt thereof. 
     
     
         42 . The kit of  claim 31 , wherein the second formulation further comprises one or more cosmetically acceptable excipients selected from the group consisting of water, surfactants, vitamins, natural extracts, perfumes, preservatives, antioxidants, chelating agents, hair coloring agents, proteins, amino acids, humectants, fragrances, emollients, penetrants, thickeners, viscosity modifiers, hair fixatives, film formers, emulsifiers, opacifying agents, propellants, liquid vehicles, carriers, salts, pH adjusting agents, neutralizing agents, buffers, hair conditioning agents, anti-static agents, anti-frizz agents, anti-dandruff agents, and combinations thereof. 
     
     
         43 . The kit of  claim 31 , wherein the active agent is present in an amount ranging from about 0.01 wt % to about 50 wt % of the second formulation. 
     
     
         44 . The kit of  claim 42 , wherein the cosmetically acceptable excipient is present in an amount ranging from about 40 wt % to about 99 wt % of the second formulation. 
     
     
         45 . The kit of  claim 31 , further comprising instructions for use, a mixing container, an odor eliminator, or a combination thereof. 
     
     
         46 . The kit of  claim 31 , wherein the second formulation is provided as two or more separate ingredients. 
     
     
         47 . The kit of  claim 31 , wherein the binding agent is provided as a dry powder in a sealed package and a cosmetically acceptable excipient is provided in a vial or other container.