Compositions for a medical device comprising exopolysaccharide-producing bacterial strains in association with gums and/or gelatines

Abstract

A composition for a medical device is described. The composition comprises a specific mucoadherent gelling complex composed of EPS, exopolysaccharides of bacterial origin produced in situ in the gastrointestinal tract by specific selected bacterial strains, in association with vegetable gums and/or animal and/or vegetable gelatines. The complex is capable of establishing a complete barrier effect of a mechanical type extending throughout the whole gastrointestinal tract and can be used as a medication for the prevention and treatment of all pathologies connected to a deficiency in the barrier effect in the gastrointestinal area due to a low production of mucus, such as, by way of non-exhaustive example, intestinal permeability and bacterial translocation.

1 .- 15 . (canceled) 
     
     
         16 . A composition comprising
 a mucoadherent gelling complex composed of
 at least one exopolysaccharides-producing bacterial strain, in combination with a vegetable gum, an animal gelatin, and/or a vegetable gelatin, 
   the at least one exopolysaccharides-producing bacterial strain capable of producing exopolysaccharides in situ in a gastrointestinal tract of a subject to protect an intestinal mucosa from pathogenic bacteria.   
     
     
         17 . The composition of  claim 16 , wherein the at least one exopolysaccharide-producing bacterial strain is a mixture of bacteria selected from the group of bacteria belonging to the species  Lactobacillus plantarum  and/or  Lactobacillus rhamnosus  and/or  Streptococcus thermophilus.    
     
     
         18 . The composition of  claim 16 , wherein the composition comprises at least one bacterial strain selected from the group consisting of:
   Streptococcus thermophilus  DSM 16590 (YO2), deposited with the depositary institution DSMZ in Germany on 20 Jul. 2004,     Streptococcus thermophilus  DSM 16592 (YO4), deposited with the depositary institution DSMZ in Germany on 20 Jul. 2004,     Streptococcus thermophilus  DSM 17843 (YO8), deposited with the depositary institution DSMZ in Germany on 21 Dec. 2005,     Streptococcus thermophilus  DSM 25246 (ST10), deposited with the depositary institution DSMZ in Germany on 19 Sep. 2011,     Streptococcus thermophilus  DSM 25247 (ST11), deposited with the depositary institution DSMZ in Germany on 19 Sep. 2011, and     Streptococcus thermophilus  DSM 25282 (ST12), deposited with the depositary institution DSMZ in Germany on 19 Sep. 2011.   
     
     
         19 . The composition of  claim 18 , wherein the composition further comprises bacterial strains of  Lactobacillus plantarum  and/or  Lactobacillus rhamnosus  capable of producing exopolysaccharides in situ in the gastrointestinal tract of a subject to protect the intestinal mucosa from the action of pathogenic bacteria. 
     
     
         20 . The composition of  claim 16 , wherein the vegetable gum and/or vegetable gelatin is  Aloe  vera or  Aloe arborescens.    
     
     
         21 . The composition of  claim 16 , wherein the vegetable gum and/or vegetable gelatin is an alginate or tara gum. 
     
     
         22 . The composition of  claim 16 , wherein the vegetable gum and/or vegetable gelatin is a xyloglucan or xylogel. 
     
     
         23 . The composition of  claim 16 , wherein the at least one exopolysaccharides-producing bacterial strain comprises at least one  Streptococcus thermophilus  strain selected from the group consisting of  Streptococcus thermophilus  DSM 16590 (YO2),  Streptococcus thermophilus  DSM 16592 (YO4),  Streptococcus thermophilus  DSM 17843 (YO8) and  Streptococcus thermophilus  DSM 25246 (ST10), and
 the vegetable gum, the animal gelatin, and/or vegetable gelatin is selected from the group consisting of  Aloe arborescens , gelatine tannate and tara gum.   
     
     
         24 . The composition of claim  1 , wherein the mucoadherent gelling complex comprises:
   Streptococcus thermophilus  DSM 25246 (ST10) in combination with a vegetable gum and/or a vegetable gelatin selected from the group consisting of  Aloe arborescens  and tara gum.   
     
     
         25 . The composition of claim  1 , wherein the mucoadherent gelling complex comprises:
   Streptococcus thermophilus  DSM 25246 (ST10) and at least one strain selected from the group consisting of  Streptococcus thermophilus  DSM 16590 (YO2),  Streptococcus thermophilus  DSM 16592 (YO4) and  Streptococcus thermophilus  DSM 17843 (YO8) in combination with a vegetable gum and/or a vegetable gelatin selected from the group consisting of  Aloe arborescens  and tara gum.   
     
     
         26 . The composition of claim  1 , wherein the mucoadherent gelling complex comprises:
   Streptococcus thermophilus  DSM 25246 (ST10) and  Streptococcus thermophilus  DSM 16592 (YO4) in combination with a vegetable gum and/or a vegetable gelatin selected from the group consisting of  Aloe arborescens  and tara gum.   
     
     
         27 . The composition of  claim 24 , where the vegetable gum and/or vegetable gelatin is tara gum.