Microstructure-based drug delivery system comprising microporous structure

Abstract

Disclosed are a microstructure-based drug delivery system comprising a microporous structure and a method for manufacturing the same, and more specifically, a detachable microstructure-based drug delivery system using a microporous structure layer and a method for manufacturing the same, thereby skipping a drying step which is essential for the manufacturing process of the existing biodegradable microneedle, and solving the problem in that the hardness of the microneedle is reduced when the microneedle contains drugs, failing to penetrate the skin. Here, the microstructure is implantable in the body through the insertion into the body and detachment from the microporous structure, and the detachable microstructure can be applied to wrinkled (skin movement) and corrugated parts through a detachment function thereof.

1 .- 19 . (canceled) 
     
     
         20 . A method for manufacturing a microstructure-based drug delivery system using a microporous structure, the method comprising:
 (a) forming a microporous structure layer on or in a protrusion-shaped pillar of a substrate,   (b) forming a microstructure on the microporous structure layer, wherein the microstructure is formed using a viscous composition containing a liquid-phase or solidphase drug if the drug is loaded in the microstructure; and   (c) loading a liquid-phase or solid-phase drug in the microporous structure layer after step (a) or (b) if the drug is loaded in the microporous structure layer,   wherein at least one of the microporous structure layer and the microstructure contains the drug.   
     
     
         21 . The method of  claim 20 , the microstructure is detachable from the substrate at the microporous structure layer. 
     
     
         22 . The method of  claim 20 , wherein the microporous structure layer of step (a) is formed by freeze-drying, electrospinning, or solvent removal. 
     
     
         23 . The method of  claim 20 , wherein the microporous structure layer of step (a) is formed upper portion or middle portion or lower portion of the protrusion-shaped pillar.