Antibodies and pharmaceutical compositions containing same useful for inhibiting activity of metalloproteins

Abstract

An antibody comprising an antigen recognition region which comprises CDR amino acid sequences set forth in SEQ ID NO: 7, 8, 9, 10, 11 and 12.

What is claimed is: 
     
         1 . A compound having the Formula (I): 
       
         
           
           
               
               
           
         
         wherein R is O—CH 2 —CH 2 —CONH—CH 2 —CH 2 —NH 2 . 
       
     
     
         2 . An antibody comprising an antigen recognition region capable of specifically binding the compound of  claim 1 . 
     
     
         3 . The antibody of  claim 2 , wherein said antigen recognition region comprises CDR amino acid sequences set forth in SEQ ID NO: 7, 8, 9, 10, 11 and 12. 
     
     
         4 . The antibody of  claim 2 , being capable of inhibiting the activity of MMP-9 and MMP-2. 
     
     
         5 . A pharmaceutical composition comprising the antibody of  claim 2  as an active agent and a pharmaceutically acceptable carrier. 
     
     
         6 . A method of treating a disease or condition associated with imbalanced or abnormal activity of metalloproteins in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of an antibody comprising an antigen recognition region capable of specifically binding the compound having the Formula: 
       
         
           
           
               
               
           
         
         wherein R is O—CH 2 —CH 2 —CONH—CH 2 —CH 2 —NH 2 , thereby treating a disease or condition associated with imbalanced or abnormal activity of metalloproteins in the subject. 
       
     
     
         7 . The method of  claim 6 , wherein the disease is an inflammatory bowel disease. 
     
     
         8 . The method of  claim 6 , wherein the disease is cancer. 
     
     
         9 . The method of  claim 6 , wherein the disease is multiple sclerosis. 
     
     
         10 . The method of  claim 6 , wherein the disease is osteoarthritis. 
     
     
         11 . The method of  claim 8 , wherein said cancer is a metastatic cancer. 
     
     
         12 . The method of  claim 6 , wherein the condition is heart failure. 
     
     
         13 . The method of  claim 6 , wherein the condition is pain.