BTLA Antibodies and Uses Thereof

Abstract

The invention relates to BTLA antibodies that block BTLA-HVEM interaction and uses thereof.

1 - 8 . (canceled) 
     
     
         9 . A method for treating a chronic infection in a human or animal body in need thereof, comprising the administration of a therapeutically effective amount of an the anti-BTLA antibody to said human or animal body. 
     
     
         10 . The method of  claim 9 , wherein said anti-BTLA antibody is an antibody that binds to BTLA and that blocks BTLA-HVEM interaction. 
     
     
         11 . The method of  claim 9 , wherein the anti-BTLA antibody is an antibody comprising the CDRs of the heavy chain variable region and the light chain variable region of the anti-BTLA antibody which is obtainable from the hybridoma accessible under CNCM deposit number I-4123. 
     
     
         12 . The method of  claim 9 , wherein said anti-BTLA antibody is obtainable from the hybridoma accessible under CNCM deposit number I-4123 or a Fab or F(ab′) 2  fragment thereof. 
     
     
         13 . The method of  claim 9 , wherein said antibody is a monoclonal, humanized or chimeric antibody. 
     
     
         14 . The method of  claim 9 , wherein said chronic infection is selected from the group consisting of viral, bacterial, parasitic or fungal infections.