Composition for improving memory, learning ability, and cognitive ability

Abstract

There is provided a composition for improving memory, learning ability, and cognitive ability. It has been confirmed that a peptide having a C-terminal region ended to GAG had an effect of improving the memory. In order for the peptide to have the effect, it has been confirmed that the peptide should be a peptide of which the length consists of at least 4 amino acids. Further, it has been confirmed that a peptide of which the length of the peptide having the C-terminal region ended to GAG consists of 5 to 9 amino acids has the same effect. As a result, the peptide of the present invention can be used as the composition for improving memory, learning ability, and cognitive ability.

What is claimed is: 
     
         1 . A peptide comprises an amino acid sequence, wherein the amino sequence is SEQ ID NO:3(AGAG), SEQ ID NO: 4(QGAG), or SEQ ID NO: 5(GGAG). 
     
     
         2 . The peptide of  claim 1 , wherein the peptide is derived from a silk fibroin. 
     
     
         3 . The peptide of  claim 1 , wherein the peptide is artificially synthesized. 
     
     
         4 . A pharmaceutical composition for preventing or treating a memory, cognitive, or learning disorder, includes the peptide of  claim 1  as an active ingredient. 
     
     
         5 . The pharmaceutical composition of  claim 4 , wherein the memory, cognitive, or learning disorder is a memory, cognitive, or learning disorder caused by aging, Alzheimer's disease, schizophrenia, Parkinson's disease, Huntington's disease, pick disease, Creutzfeldt-Jakob disease, depression, aging, head injury, stroke, CNS hypoxia, cerebral ischemia, encephalitis, forgetfulness, traumatic brain injury, hypoglycaemia, Wernicke-Korsakoff syndrome, drug addiction, epilepsy, fasciola hepatica, hippocampal sclerosis, headache, brain aging, dementia, frontotemporal lobar degeneration, tumor, normal pressure hydrocephalus, HIV, cerebrovascular disease, cerebral disease, cardiovascular disease, amnesia, radiation exposure, metabolic disease, hypothyroidism, mild cognitive impairment, cognitive deficiency and attention deficit. 
     
     
         6 . A food composition for enhancement of a brain or cognitive function, the food composition comprising the peptide of  claim 1  as an active ingredient. 
     
     
         7 . The food composition of  claim 6 , wherein the brain or cognitive function is a learning ability, a memory ability, or concentration. 
     
     
         8 . A polynucleotide encoding the peptide of  claim 1 . 
     
     
         9 . A recombinant vector including the polynucleotide of  claim 8 . 
     
     
         10 . A host cell transformed with the recombinant vector of  claim 9 . 
     
     
         11 . A method of preparing a peptide comprising incubating the host cell of  claim 10 .